scholarly journals An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer

2014 ◽  
Vol 16 (3) ◽  
Author(s):  
Misako Sato ◽  
Mitsutaka Kadota ◽  
Binwu Tang ◽  
Howard H Yang ◽  
Yu-an Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Breast ◽  
Genomic Approach

The cytostatic effects of α-interferon may be mediated by transforming growth factor-β

1989 ◽  
Vol 2 (2) ◽  
pp. 131-136 ◽  
Author(s):  
D. J. Kerr ◽  
I. B. Pragnell ◽  
A. Sproul ◽  
S. Cowan ◽  
T. Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Cancer Cell Line ◽  
Transforming Growth Factor Β ◽  
Human Breast Cancer Cell ◽  
Human Breast

ABSTRACT There is some evidence to suggest that transforming growth factor-β (TGF-β) mediates the cytostatic effects of the anti-oestrogen tamoxifen. In this study we have demonstrated that α-interferon has a significant anti-proliferative effect on the oestrogen receptor-positive human breast cancer cell line ZR-75. There is decreased phenotypic expression of the oestrogen receptors (to about 30% of control values) and increased TGF-β mRNA. Under the growth conditions used here, ZR-75 cells had approximately 5800 TGF-β binding sites per cell, with an apparent dissociation constant of 70 pm, and we have shown that the anti-proliferative effects of α-interferon can be reduced by 60% by co-treating the cells with a TGF-β polyclonal antibody. The cytostatic effects of α-interferon may therefore be mediated by TGF-β in this human breast cancer cell line.

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

Cell ◽  
1987 ◽  
Vol 48 (3) ◽  
pp. 417-428 ◽  
Author(s):  
Cornelius Knabbe ◽  
Marc E. Lippman ◽  
Lalage M. Wakefield ◽  
Kathleen C. Flanders ◽  
Attan Kasid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Negative Growth
Sign in / Sign up

Export Citation Format

Share Document