scholarly journals Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions

2014 ◽  
Vol 16 (2) ◽  
Author(s):  
Agnieszka K Witkiewicz ◽  
Erik S Knudsen
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Precision Medicine ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Therapeutic Interventions ◽  
Retinoblastoma Tumor Suppressor ◽  
Retinoblastoma Tumor

scholarly journals The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

2007 ◽  
Vol 117 (1) ◽  
pp. 218-228 ◽  
Author(s):  
Emily E. Bosco ◽  
Ying Wang ◽  
Huan Xu ◽  
Jack T. Zilfou ◽  
Karen E. Knudsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Therapeutic Response ◽  
Retinoblastoma Tumor Suppressor ◽  
Retinoblastoma Tumor

scholarly journals The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer

Oncogene ◽  
2013 ◽  
Vol 33 (30) ◽  
pp. 3980-3991 ◽  
Author(s):  
A K Witkiewicz ◽  
D W Cox ◽  
D Rivadeneira ◽  
A E Ertel ◽  
P Fortina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Retinoblastoma Tumor Suppressor ◽  
Retinoblastoma Tumor ◽  
Positive Breast Cancer

scholarly journals The role of KPNA2 mutations in breast cancer prognosis: A survey of publicly available databases

2021 ◽  
Author(s):  
Layla Alnoumas ◽  
Lisa van den driest ◽  
Alison Lannigan ◽  
Caroline H Johnson ◽  
Nicholas JW Rattray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Patient Survival ◽  
Chemotherapy Resistance ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Therapeutic Interventions ◽  
Poor Patient ◽  
Patient Prognosis ◽  
The Uk

Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer remain a particular challenge. However, the rapidly-growing availability of clinical datasets, presents the scope to underpin a data driven precision medicine-based approach exploring new targets for diagnostic and therapeutic interventions. We report a survey of several publicly available databases probing the expression and prognostic role of Karyopherin-2 alpha (KPNA2) in breast cancer prognosis. Aberrant KPNA2 overexpression is directly correlated with aggressive tumour phenotypes and poor patient survival outcomes. We examined the existing information available on a range of commonly occurring mutations of KPNA2 and their correlation with patient survival. Our analysis of clinical gene expression datasets show that KPNA2 is frequently amplified in breast cancer, with differences in expression levels observed as a function of patient age and clinicopathologic parameters. We also found that aberrant KPNA2 overexpression is directly correlated with poor patient prognosis, warranting further investigation of KPNA2 as an actionable target for patient stratification or the design of novel chemotherapy agents. In the era of big data, the wealth of datasets available in the public domain can be used to underpin proof of concept studies evaluating the biomolecular pathways implicated in chemotherapy resistance in breast cancer.

scholarly journals Influence of tumor location on breast cancer prognosis

2003 ◽  
Vol 105 (4) ◽  
pp. 542-545 ◽  
Author(s):  
Niels Kroman ◽  
Jan Wohlfahrt ◽  
Henning T. Mouridsen ◽  
Mads Melbye
Keyword(s):  
Breast Cancer ◽  
Tumor Location ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis

New markers for breast cancer prognosis

1993 ◽  
Vol 47 (6-7) ◽  
pp. 256
Author(s):  
F. Di Carlo ◽  
S. Racca ◽  
G. Conti ◽  
M. Tampellini ◽  
F. Pietribiasi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis
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