scholarly journals Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?

2012 ◽  
Vol 14 (6) ◽  
Author(s):  
Max S Wicha
Keyword(s):  
Gene Expression ◽  
Patient Outcome ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Poor Patient ◽  
Poor Patient Outcome

A gene expression signature to characterize human lung adenocarcinoma cancer stem cells.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e20547-e20547
Author(s):  
Alejandro Herreros-Pomares ◽  
Juan Diego de Maya ◽  
Héctor Amado ◽  
Cristóbal Aguilar-Gallardo ◽  
Eva Escorihuela ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Human Lung Adenocarcinoma ◽  
Lung Adenocarcinoma Cancer

scholarly journals A distinct gene expression signature characterizes human neuroblastoma cancer stem cells

2015 ◽  
Vol 15 (2) ◽  
pp. 419-426 ◽  
Author(s):  
Robert A. Ross ◽  
Jeanette D. Walton ◽  
Dan Han ◽  
Hong-Fen Guo ◽  
Nai-Kong V. Cheung
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gene Expression Signature ◽  
Human Neuroblastoma ◽  
Expression Signature ◽  
Distinct Gene

NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells

2016 ◽  
Vol 45 ◽  
pp. 1-7 ◽  
Author(s):  
Hao Ho ◽  
Alyza M. Skaist ◽  
Aparna Pallavajjala ◽  
Raluca Yonescu ◽  
Denise Batista ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Gene Expression Signature ◽  
Leukemic Stem Cells ◽  
Expression Signature ◽  
Acute Myeloid

scholarly journals Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro

2011 ◽  
Vol 301 (3) ◽  
pp. R727-R745 ◽  
Author(s):  
Hady Felfly ◽  
Jin Xue ◽  
Alexander C. Zambon ◽  
Alysson Muotri ◽  
Dan Zhou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Neuronal Differentiation ◽  
Gene Expression Signature ◽  
Neuronal Morphology ◽  
Primary Neurons ◽  
Embryonic Mouse ◽  
Expression Signature ◽  
Neuronal Gene

Stem cells are a potential key strategy for treating neurodegenerative diseases in which the generation of new neurons is critical. A better understanding of the characteristics and molecular properties of neural stem cells (NSCs) and differentiated neurons can help with assessing neuronal maturity and, possibly, in devising better therapeutic strategies. We have performed an in-depth gene expression profiling study of murine NSCs and primary neurons derived from embryonic mouse brains. Microarray analysis revealed a neuron-specific gene expression signature that distinguishes primary neurons from NSCs, with elevated levels of transcripts involved in neuronal functions, such as neurite development and axon guidance in primary neurons and decreased levels of multiple cytokine transcripts. Among the differentially expressed genes, we found a statistically significant enrichment of genes in the ephrin, neurotrophin, CDK5, and actin pathways, which control multiple neuronal-specific functions. We then artificially blocked the cell cycle of NSCs with mitomycin C (MMC) and examined cellular morphology and gene expression signatures. Although these MMC-treated NSCs displayed a neuronal morphology and expressed some neuronal differentiation marker genes, their gene expression patterns were very different from primary neurons. We conclude that 1) fully differentiated mouse primary neurons display a specific neuronal gene expression signature; 2) cell cycle block at the S phase in NSCs with MMC does not induce the formation of fully differentiated neurons; 3) cytokines change their expression pattern during differentiation of NSCs into neurons; and 4) signaling pathways of ephrin, neurotrophin, CDK5, and actin, related to major neuronal features, are dynamically enriched in genes showing changes in expression level.

A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma

2008 ◽  
Vol 216 (2) ◽  
pp. 158-166 ◽  
Author(s):  
S Boeuf ◽  
P Kunz ◽  
T Hennig ◽  
B Lehner ◽  
PCW Hogendoorn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals A gene expression signature shared by human mature oocytes and embryonic stem cells

BMC Genomics ◽  
2009 ◽  
Vol 10 (1) ◽  
pp. 10 ◽  
Author(s):  
Said Assou ◽  
Doris Cerecedo ◽  
Sylvie Tondeur ◽  
Véronique Pantesco ◽  
Outi Hovatta ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

Blood ◽  
2008 ◽  
Vol 111 (12) ◽  
pp. 5654-5662 ◽  
Author(s):  
Duane C. Hassane ◽  
Monica L. Guzman ◽  
Cheryl Corbett ◽  
Xiaojie Li ◽  
Ramzi Abboud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
High Throughput ◽  
In Silico ◽  
High Throughput Screening ◽  
Drug Targets ◽  
Expression Profiles ◽  
Gene Expression Signature ◽  
Myelogenous Leukemia ◽  
Expression Signature

Abstract Increasing evidence indicates that malignant stem cells are important for the pathogenesis of acute myelogenous leukemia (AML) and represent a reservoir of cells that drive the development of AML and relapse. Therefore, new treatment regimens are necessary to prevent relapse and improve therapeutic outcomes. Previous studies have shown that the sesquiterpene lactone, parthenolide (PTL), ablates bulk, progenitor, and stem AML cells while causing no appreciable toxicity to normal hematopoietic cells. Thus, PTL must evoke cellular responses capable of mediating AML selective cell death. Given recent advances in chemical genomics such as gene expression-based high-throughput screening (GE-HTS) and the Connectivity Map, we hypothesized that the gene expression signature resulting from treatment of primary AML with PTL could be used to search for similar signatures in publicly available gene expression profiles deposited into the Gene Expression Omnibus (GEO). We therefore devised a broad in silico screen of the GEO database using the PTL gene expression signature as a template and discovered 2 new agents, celastrol and 4-hydroxy-2-nonenal, that effectively eradicate AML at the bulk, progenitor, and stem cell level. These findings suggest the use of multicenter collections of high-throughput data to facilitate discovery of leukemia drugs and drug targets.

scholarly journals An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141066 ◽  
Author(s):  
Brian W. Busser ◽  
Yongshun Lin ◽  
Yanqin Yang ◽  
Jun Zhu ◽  
Guokai Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Gene Expression Signature ◽  
Expression Signature
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