scholarly journals Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells

2012 ◽  
Vol 14 (4) ◽  
Author(s):  
Jhen-Wei Ruan ◽  
Yi-Chu Liao ◽  
Ingrid Lua ◽  
Ming-Hsun Li ◽  
Chih-Yi Hsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Breast Cancer Cells ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

scholarly journals Pituitary Tumor-Transforming Gene 1 Is Expressed in Primary Ductal Breast Carcinoma, Lymph Node Infiltration, and Distant Metastases

2013 ◽  
Vol 35 ◽  
pp. 267-272 ◽  
Author(s):  
Fabio Grizzi ◽  
Sonia Di Biccari ◽  
Barbara Fiamengo ◽  
Sanja Štifter ◽  
Piergiuseppe Colombo
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Breast Cancer Cells ◽  
Distant Metastases ◽  
Pituitary Tumor Transforming Gene ◽  
Ductal Breast Carcinoma ◽  
Transforming Gene

Despite the advances that have been made in the fields of molecular and cell biology, there is still considerable debate explaining how the breast cancer cells progress through carcinogenesis and acquire their metastatic ability. The lack of preventive methods and effective therapies underlines the pressing need to identify new biomarkers that can aid early diagnosis and may be targets for effective therapeutic strategies. In this study we explore the pituitary tumor-transforming gene 1 (PTTG1) expression in primary ductal breast carcinoma, lymph node infiltration, and distant metastases. Three human cell lines, 184B5 derived from normal mammary epithelium, HCC70 from a primary ductal carcinoma, and MDA-MB-361 from a breast metastasis, were used for quantifying PTTG1 mRNA expression. The PTTG1 immunohistochemical expression was carried out on specimens taken from eight patients with invasive ductal breast cancer who underwent surgical treatment and followup for five years retrospectively selected. The study demonstrated that PTTG1 is expressed gradually in primary ductal breast carcinoma, lymph node infiltration, and distant metastases. Our findings suggest that the immunohistochemical evaluation of PTTG1 expression might be a powerful biomarker of recognition and quantification of the breast cancer cells in routine pathological specimens and a potential target for developing an effective immunotherapeutic strategy for primary and metastatic breast cancer.

scholarly journals Human Pituitary Tumor-Transforming Gene (PTTG1) Motif Suppresses Prolactin Expression

2003 ◽  
Vol 17 (4) ◽  
pp. 600-609 ◽  
Author(s):  
Gregory A. Horwitz ◽  
Irina Miklovsky ◽  
Anthony P. Heaney ◽  
Song-Guang Ren ◽  
Shlomo Melmed
Keyword(s):  
Pituitary Tumor ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

scholarly journals Human Pituitary Tumor-Transforming Gene Induces Angiogenesis1

2001 ◽  
Vol 86 (2) ◽  
pp. 867-874 ◽  
Author(s):  
Hiroki Ishikawa ◽  
Anthony P. Heaney ◽  
Run Yu ◽  
Gregory A. Horwitz ◽  
Shlomo Melmed
Keyword(s):  
Pituitary Tumor ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene ◽  
Human Pituitary Tumor

Human Pituitary Tumor Transforming Gene 1 (Hpttg1) in Gastric Mucosal Tissues

2001 ◽  
Vol 96 (4) ◽  
pp. 1313-1314 ◽  
Author(s):  
M Yamada ◽  
K Asanuma ◽  
A Yagihashi ◽  
M Nakamura ◽  
H Kameshima ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Human Pituitary ◽  
Pituitary Tumor Transforming Gene ◽  
Mucosal Tissues ◽  
Transforming Gene ◽  
Human Pituitary Tumor
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