scholarly journals Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells

2012 ◽  
Vol 14 (1) ◽  
Author(s):  
Sabine Kasimir-Bauer ◽  
Oliver Hoffmann ◽  
Diethelm Wallwiener ◽  
Rainer Kimmig ◽  
Tanja Fehm
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Primary Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Breast Cancer Patients ◽  
Mesenchymal Transition

scholarly journals Expression of Stem Cell and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells of Breast Cancer Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Natalia Krawczyk ◽  
Franziska Meier-Stiegen ◽  
Malgorzata Banys ◽  
Hans Neubauer ◽  
Eugen Ruckhaeberle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Breast ◽  
Current Data ◽  
Stem Cell Markers ◽  
Breast Cancer Patients ◽  
Mesenchymal Transition

Evaluation and characterization of circulating tumor cells (CTCs) have become a major focus of translational cancer research. Presence of CTCs predicts worse clinical outcome in early and metastatic breast cancer. Whether all cells from the primary tumor have potential to disseminate and form subsequent metastasis remains unclear. As part of the metastatic cascade, tumor cells lose their cell-to-cell adhesion and undergo epithelial-mesenchymal transition (EMT) in order to enter blood circulation. During EMT epithelial antigens are downregulated; thus, such tumor cells might elude classical epithelial marker-based detection. Several researchers postulated that some CTCs express stem cell-like phenotype; this might lead to chemoresistance and enhanced metastatic potential of such cells. In the present review, we discuss current data on EMT and stem cell markers in CTCs of breast cancer and their clinical significance.

Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients

2011 ◽  
Vol 130 (2) ◽  
pp. 449-455 ◽  
Author(s):  
Cristina Raimondi ◽  
Angela Gradilone ◽  
Giuseppe Naso ◽  
Bruno Vincenzi ◽  
Arianna Petracca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Epithelial Mesenchymal Transition ◽  
Breast Cancer Patients ◽  
Mesenchymal Transition

scholarly journals Circulating tumor cells and drug history in primary breast cancer patients

2020 ◽  
Author(s):  
Silvia Jurisova ◽  
Marián Karaba ◽  
Gabriel Minarik ◽  
Juraj Benca ◽  
Tatiana Sedlackova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Primary Breast Cancer ◽  
Breast Cancer Patients ◽  
Drug History
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