scholarly journals Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

2012 ◽  
Vol 14 (1) ◽  
Author(s):  
Luciana P Schwab ◽  
Danielle L Peacock ◽  
Debeshi Majumdar ◽  
Jesse F Ingels ◽  
Laura C Jensen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Hypoxia Inducible Factor ◽  
Cell Activity ◽  
Primary Tumor Growth ◽  
Hypoxia Inducible Factor 1Α ◽  
Tumor Initiating Cell

scholarly journals Host deficiency in ephrin-A1 inhibits breast cancer metastasis

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 217 ◽  
Author(s):  
Eileen Shiuan ◽  
Ashwin Inala ◽  
Shan Wang ◽  
Wenqiang Song ◽  
Victoria Youngblood ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Lung Metastasis ◽  
Primary Tumor ◽  
Tumor Recurrence ◽  
Cancer Metastasis ◽  
Primary Tumor Growth ◽  
Primary Tumors ◽  
4T1 Cells

Background: The conventional dogma of treating cancer by focusing on the elimination of tumor cells has been recently refined to include consideration of the tumor microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein involved in adhesion and migration, has been shown to be tumor suppressive in the context of the cancer cell. However, its role in the host has not been fully investigated. Here, we examine how ephrin-A1 host deficiency affects cancer growth and metastasis in a murine model of breast cancer. Methods: 4T1 cells were orthotopically implanted into the mammary fat pads or injected into the tail veins of ephrin-A1 wild-type (Efna1+/+), heterozygous (Efna1+/-), or knockout (Efna1-/-) mice. Tumor growth, lung metastasis, and tumor recurrence after surgical resection were measured. Flow cytometry and immunohistochemistry (IHC) were used to analyze various cell populations in primary tumors and tumor-bearing lungs. Results: While primary tumor growth did not differ between Efna1+/+, Efna1+/-, and Efna1-/- mice, lung metastasis and primary tumor recurrence were significantly decreased in knockout mice. Efna1-/- mice had reduced lung colonization of 4T1 cells compared to Efna1+/+ littermate controls as early as 24 hours after tail vein injection. Furthermore, established lung lesions in Efna1-/- mice had reduced proliferation compared to those in Efna1+/+ controls. Conclusions: Our studies demonstrate that host deficiency of ephrin-A1 does not impact primary tumor growth but does affect metastasis by providing a less favorable metastatic niche for cancer cell colonization and growth. Elucidating the mechanisms by which host ephrin-A1 impacts cancer relapse and metastasis may shed new light on novel therapeutic strategies.

scholarly journals An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29615 ◽  
Author(s):  
Manisha Shah ◽  
Dexing Huang ◽  
Tony Blick ◽  
Andrea Connor ◽  
Lawrence A. Reiter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Experimental Models ◽  
Selective Inhibitor ◽  
Primary Tumor Growth ◽  
Osteolytic Lesions

A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer

2009 ◽  
Vol 155 (2) ◽  
pp. 231-236 ◽  
Author(s):  
Eugene H. Huang ◽  
Balraj Singh ◽  
Massimo Cristofanilli ◽  
Juri Gelovani ◽  
Caimiao Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Primary Tumor Growth ◽  
Cxcr4 Antagonist ◽  
Tumor Growth And Metastasis

scholarly journals Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth

Oncogene ◽  
2016 ◽  
Vol 35 (46) ◽  
pp. 5977-5988 ◽  
Author(s):  
S J Werden ◽  
N Sphyris ◽  
T R Sarkar ◽  
A N Paranjape ◽  
A M LaBaff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Primary Tumor Growth

scholarly journals In vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer

2010 ◽  
Vol 70 (10) ◽  
pp. 3905-3914 ◽  
Author(s):  
Xin Lu ◽  
Carol H. Yan ◽  
Min Yuan ◽  
Yong Wei ◽  
Guohong Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Primary Tumor Growth ◽  
Organotropic Metastasis
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