scholarly journals The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients

2011 ◽  
Vol 13 (3) ◽  
Author(s):  
Timothy J Molloy ◽  
Astrid J Bosma ◽  
Lars O Baumbusch ◽  
Marit Synnestvedt ◽  
Elin Borgen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumour Cell ◽  
Peripheral Blood ◽  
Early Stage ◽  
Prognostic Significance ◽  
Early Stage Breast Cancer ◽  
Cell Detection ◽  
Breast Cancer Patients

Treg and Teff in the bone marrow of early-stage breast cancer patients with disseminated tumor cells.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e21049-e21049
Author(s):  
D. G. Wolf ◽  
D. Fong ◽  
L. Scherrer ◽  
A. Wolf ◽  
D. Reimer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Early Stage ◽  
Disseminated Tumor Cells ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Patients

scholarly journals Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 652 ◽  
Author(s):  
Areti Strati ◽  
Michail Nikolaou ◽  
Vassilis Georgoulias ◽  
Evi Lianidou
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Early Stage ◽  
Prognostic Significance ◽  
Early Stage Breast Cancer ◽  
Rank Test ◽  
Breast Cancer Patients ◽  
Log Rank Test

(1) Background: The aim of the study was to evaluate the prognostic significance of EMT-associated (TWIST1) and stem-cell (SC) transcript (CD24, CD44, ALDH1) quantification in EpCAM+ circulating tumor cells (CTCs) of early breast cancer patients. (2) Methods: 100 early stage breast cancer patients and 19 healthy donors were enrolled in the study. CD24, CD44, and ALDH1 transcripts of EpCAM+ cells were quantified using a novel highly sensitive and specific quadraplex RT-qPCR, while TWIST1 transcripts were quantified by single RT-qPCR. All patients were followed up for more than 5 years. (3) Results: A significant positive correlation between overexpression of TWIST1 and CD24−/low/CD44high profile was found. Kaplan–Meier analysis revealed that the ER/PR-negative (HR-) patients and those patients with more than 3 positive lymph nodes that overexpressed TWIST1 in EpCAM+ cells had a significant lower DFI (log rank test; p < 0.001, p < 0.001) and OS (log rank test; p = 0.006, p < 0.001). Univariate and multivariate analysis also revealed the prognostic value of TWIST1 overexpression and CD24−/low/CD44high and CD24−/low/ALDH1high profile for both DFI and OS. (4) Conclusions: Detection of TWIST1 overexpression and stem-cell (CD24, CD44, ALDH1) transcripts in EpCAM+ CTCs provides prognostic information in early stage breast cancer patients.

Sign in / Sign up

Export Citation Format

Share Document