scholarly journals Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator

2011 ◽  
Vol 13 (2) ◽  
Author(s):  
Wonchung Lim ◽  
Yeomyung Park ◽  
Jungyoon Cho ◽  
Choa Park ◽  
Joonwoo Park ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Transcriptional Activity ◽  
Hypoxia Inducible Factor ◽  
Estrogen Receptor Beta ◽  
Hypoxia Inducible Factor 1 ◽  
Arylhydrocarbon Receptor ◽  
Receptor Beta

scholarly journals Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 722
Author(s):  
Maobi Zhu ◽  
Sen Takeda ◽  
Tomohiko Iwano
Keyword(s):  
Estrogen Receptor ◽  
Cell Differentiation ◽  
Epithelial Cells ◽  
Fallopian Tube ◽  
Ciliated Cell ◽  
Estrogen Receptor Beta ◽  
Notch Pathway ◽  
Secretory Cells ◽  
Ciliated Cells ◽  
Receptor Beta

Phytoestrogens are herbal polyphenolic compounds that exert various estrogen-like effects in animals and can be taken in easily from a foodstuff in daily life. The fallopian tube lumen, where transportation of the oocyte occurs, is lined with secretory cells and multi-ciliated epithelial cells. Recently, we showed that estrogen induces multi-ciliogenesis in the porcine fallopian tube epithelial cells (FTECs) through the activation of the estrogen receptor beta (ERβ) pathway and simultaneous inhibition of the Notch pathway. Thus, ingested phytoestrogens may induce FTEC ciliogenesis and thereby affect the fecundity. To address this issue, we added isoflavones (genistein, daidzein, or glycitin) and coumestan (coumestrol) to primary culture FTECs under air–liquid interface conditions and assessed the effects of each compound. All phytoestrogens except glycitin induced multi-ciliated cell differentiation, which followed Notch signal downregulation. On the contrary, the differentiation of secretory cells decreased slightly. Furthermore, genistein and daidzein had a slight effect on the proportion of proliferating cells exhibited by Ki67 expression. Ciliated-cell differentiation is inhibited by the ERβ antagonist, PHTPP. Thus, this study suggests that phytoestrogens can improve the fallopian tube epithelial sheet homeostasis by facilitating the genesis of multi-ciliated cells and this effect depends on the ERβ-mediated pathway.

A methylation signature at the CpG island promoter of estrogen receptor beta (ER-β) in breasts of women may be an early footmark of lack of breastfeeding and nulliparity

2021 ◽  
Vol 218 ◽  
pp. 153328
Author(s):  
Abdolreza Daraei ◽  
Pantea Izadi ◽  
Ghasemali Khorasani ◽  
Nahid Nafissi ◽  
Mohammad Mehdi Naghizadeh ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cpg Island ◽  
Estrogen Receptor Beta ◽  
Receptor Beta

scholarly journals Estrogen Receptor beta in Health and Disease1

2005 ◽  
Vol 73 (5) ◽  
pp. 866-871 ◽  
Author(s):  
Otabek Imamov ◽  
Gil-Jin Shim ◽  
Margaret Warner ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Beta ◽  
Receptor Beta
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