scholarly journals Radiotherapy fraction size sensitivity is modulated by DNA repair systems

2010 ◽  
Vol 12 (S1) ◽  
Author(s):  
N Somaiah ◽  
J Yarnold ◽  
F Daley ◽  
A Pearson ◽  
K Rothkamm ◽  
...  
Keyword(s):  
Dna Repair ◽  
Fraction Size ◽  
Repair Systems

scholarly journals Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1423
Author(s):  
Artem V. Luzhin ◽  
Bogdan Avanesyan ◽  
Artem K. Velichko ◽  
Victoria O. Shender ◽  
Natalia Ovsyannikova ◽  
...  
Keyword(s):  
Dna Repair ◽  
Elevated Temperatures ◽  
Proteomics Data ◽  
Damage Response ◽  
Dna Replication And Repair ◽  
Repair Systems ◽  
Adjuvant Effects ◽  
Cancer Tissues ◽  
Functional Analyses ◽  
First Time

Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy for decades. In addition to its effects on perfusion and oxygenation of cancer tissues, hyperthermia can enhance the efficacy of DNA-damaging treatments such as radiotherapy and chemotherapy. Although it is believed that the adjuvant effects are based on hyperthermia-induced dysfunction of DNA repair systems, the mechanisms of these dysfunctions remain elusive. Here, we propose that elevated temperatures can induce chromatin trapping (c-trapping) of essential factors, particularly those involved in DNA repair, and thus enhance the sensitization of cancer cells to DNA-damaging therapeutics. Using mass spectrometry-based proteomics, we identified proteins that could potentially undergo c-trapping in response to hyperthermia. Functional analyses of several identified factors involved in DNA repair demonstrated that c-trapping could indeed be a mechanism of hyperthermia-induced transient deficiency of DNA repair systems. Based on our proteomics data, we showed for the first time that hyperthermia could inhibit maturation of Okazaki fragments and activate a corresponding poly(ADP-ribose) polymerase-dependent DNA damage response. Together, our data suggest that chromatin trapping of factors involved in DNA repair and replication contributes to heat-induced radio- and chemosensitization.

T2079 Frequency of Microsatellite Instability and Alterations of DNA Repair Systems in Non-Dysplastic Mucosa of Inflammatory Bowel Disease Patients

2008 ◽  
Vol 134 (4) ◽  
pp. A-614
Author(s):  
Alfredo Papa ◽  
Simona Guglielmo ◽  
Paola Fortini ◽  
Ida Casorelli ◽  
Federica Chiera ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Dna Repair ◽  
Microsatellite Instability ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Repair Systems

scholarly journals Defective DNA repair systems and the development of breast and prostate cancer

2012 ◽  
Vol 42 (1) ◽  
pp. 29-34 ◽  
Author(s):  
YASUKO KITAGISHI ◽  
MAYUMI KOBAYASHI ◽  
SATORU MATSUDA
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Repair Systems ◽  
Breast And Prostate Cancer ◽  
Defective Dna Repair

Triazene compounds: Mechanism of action and related DNA repair systems

2007 ◽  
Vol 56 (4) ◽  
pp. 275-287 ◽  
Author(s):  
F MARCHESI ◽  
M TURRIZIANI ◽  
G TORTORELLI ◽  
G AVVISATI ◽  
F TORINO ◽  
...  
Keyword(s):  
Dna Repair ◽  
Mechanism Of Action ◽  
Repair Systems

Significant down-regulation of DNA repair systems in non-small cell lung tumours that reactivate telomerase

2008 ◽  
Vol 6 (9) ◽  
pp. 19
Author(s):  
C. Frías ◽  
P. Ortega ◽  
A. Morán ◽  
C. De Juan ◽  
T. Fernández-Marcelo ◽  
...  
Keyword(s):  
Dna Repair ◽  
Small Cell ◽  
Small Cell Lung ◽  
Down Regulation ◽  
Lung Tumours ◽  
Repair Systems

Role of DNA repair systems in malignant tumor development in the elderly

2008 ◽  
Vol 8 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Tomio Arai ◽  
Motoji Sawabe ◽  
Takayuki Hosoi ◽  
Noriko Tanaka
Keyword(s):  
Dna Repair ◽  
Malignant Tumor ◽  
Tumor Development ◽  
The Elderly ◽  
Repair Systems
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