scholarly journals Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study

2009 ◽  
Vol 11 (4) ◽  
Author(s):  
Meira Epplein ◽  
Yurii B Shvetsov ◽  
Lynne R Wilkens ◽  
Adrian A Franke ◽  
Robert V Cooney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Postmenopausal Breast Cancer ◽  
Case Control ◽  
Multiethnic Cohort ◽  
Nested Case Control ◽  
Control Study

scholarly journals Circulating carotenoids and breast cancer among high-risk individuals

2020 ◽  
Author(s):  
Cheng Peng ◽  
Chi Gao ◽  
Donghao Lu ◽  
Bernard A Rosner ◽  
Oana Zeleznik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Risk ◽  
Case Control Study ◽  
Case Control ◽  
Polygenic Risk Score ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Carotenoids represent 1 of few modifiable factors to reduce breast cancer risk. Elucidation of interactions between circulating carotenoids and genetic predispositions or mammographic density (MD) may help inform more effective primary preventive strategies in high-risk populations. Objectives We tested whether women at high risk for breast cancer due to genetic predispositions or high MD would experience meaningful and greater risk reduction from higher circulating levels of carotenoids in a nested case-control study in the Nurses’ Health Studies (NHS and NHSII). Methods This study included 1919 cases and 1695 controls in a nested case-control study in the NHS and NHSII. We assessed both multiplicative and additive interactions. RR reductions and 95% CIs were calculated using unconditional logistic regressions, adjusting for matching factors and breast cancer risk factors. Absolute risk reductions (ARR) were calculated based on Surveillance, Epidemiology, and End Results incidence rates. Results We showed that compared with women at low genetic risk or low MD, those with higher genetic risk scores or high MD had greater ARRs for breast cancer as circulating carotenoid levels increase (additive P-interaction = 0.05). Among women with a high polygenic risk score, those in the highest quartile of circulating carotenoids had a significant ARR (28.6%; 95% CI, 14.8–42.1%) compared to those in the lowest quartile of carotenoids. For women with a high percentage MD (≥50%), circulating carotenoids were associated with a 37.1% ARR (95% CI, 21.7–52.1%) when comparing the highest to the lowest quartiles of circulating carotenoids. Conclusions The inverse associations between circulating carotenoids and breast cancer risk appeared to be more pronounced in high-risk women, as defined by germline genetic makeup or MD.

scholarly journals Weight and weight changes throughout life and postmenopausal breast cancer risk: a case-control study in France

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Emilie Cordina-Duverger ◽  
Thérèse Truong ◽  
Antoinette Anger ◽  
Marie Sanchez ◽  
Patrick Arveux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Postmenopausal Breast Cancer ◽  
Case Control ◽  
Weight Changes ◽  
Postmenopausal Breast Cancer Risk ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document