scholarly journals Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

2008 ◽  
Vol 10 (4) ◽  
Author(s):  
David I Rodenhiser ◽  
Joseph Andrews ◽  
Wendy Kennette ◽  
Bekim Sadikovic ◽  
Ariel Mendlowitz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Functional Analysis ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Whole Genome ◽  
Tiling Microarrays ◽  
Metastasis Model

Abstract 4419: Effect of sphingosine kinase 1 inhibition in validated syngeneic mouse breast cancer metastasis model

2011 ◽  
Author(s):  
Masayuki Nagahashi ◽  
Omar M. Rashid ◽  
Subramanian Ramachandran ◽  
Sheldon Milstien ◽  
Sarah Spiegel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metastasis ◽  
Sphingosine Kinase ◽  
Breast Cancer Metastasis ◽  
Sphingosine Kinase 1 ◽  
Syngeneic Mouse ◽  
Mouse Breast Cancer ◽  
Metastasis Model

Transcriptome Analysis and In Vivo Activity of Fluvastatin versus Zoledronic Acid in a Murine Breast Cancer Metastasis Model

2012 ◽  
Vol 82 (3) ◽  
pp. 521-528 ◽  
Author(s):  
Nadejda Vintonenko ◽  
Jean-Philippe Jais ◽  
Nadim Kassis ◽  
Mohamed Abdelkarim ◽  
Gerard-Yves Perret ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Transcriptome Analysis ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Metastasis Model

Realgar Nanoparticles Inhibit Migration, Invasion and Metastasis in a Mouse Model of Breast Cancer by Suppressing Matrix Metalloproteinases and Angiogenesis

2020 ◽  
Vol 17 (2) ◽  
pp. 148-158 ◽  
Author(s):  
Xi Xiaoxia ◽  
Sun Jing ◽  
Xi Dongbin ◽  
Tian Yonggang ◽  
Zhang Jingke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liver Cancer ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Migration And Invasion ◽  
Invasion And Metastasis ◽  
Mouse Breast Cancer ◽  
Metastasis Model

Background: Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly better than those of ordinary realgar. Objective: To explore the inhibitory effects and molecular mechanisms of nano-realgar on the migration, invasion and metastasis of mouse breast cancer cells. Methods: Wound-healing migration assays and Transwell invasion assays were carried out to determine the effects of nano-realgar on breast cancer cell (4T1) migration and invasion. The expression levels of matrix metalloproteinase (MMP)-2 and -9 were measured by Western blot. A murine breast cancer metastasis model was established, administered nano-realgar for 32 days and monitored for tumor growth and metastasis by an in vivo optical imaging system. Finally, living imaging and hematoxylin and eosin (HE) staining were used to measure the morphology and pathology of lung and liver cancer cell metastases, respectively. Angiogenesis was assessed by CD34 immunohistochemistry. Results: Nano-realgar significantly inhibited the migration and invasion of breast cancer 4T1 cells and the expression of MMP-2 and -9. Meanwhile, nano-realgar effectively suppressed the abilities of tumor growth, metastasis and angiogenesis in the murine breast cancer metastasis model in a time- and dosedependent manner. Conclusion: Nano-realgar significantly inhibited migration and invasion of mouse breast cancer cells in vitro as well as pulmonary and hepatic metastasis in vivo, which may be closely correlated with the downexpression of MMP-2 and -9 and suppression of tumor neovascularization.

Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model

Cytotherapy ◽  
2009 ◽  
Vol 11 (3) ◽  
pp. 289-298 ◽  
Author(s):  
Bo Sun ◽  
Kyoung-Hwan Roh ◽  
Jeong-Ran Park ◽  
Sae-Rom Lee ◽  
Sang-Bum Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Cancer Metastasis ◽  
Therapeutic Potential ◽  
Breast Cancer Metastasis ◽  
Mouse Breast Cancer ◽  
Metastasis Model
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