scholarly journals AGR2, a novel metastasis inducing protein with an effect on breast cancer patient survival

2006 ◽  
Vol 8 (S2) ◽  
Author(s):  
DL Barraclough ◽  
H Innes ◽  
S Taylor ◽  
MPA Davies ◽  
A Platt-Higgins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Patient Survival

scholarly journals Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2230 ◽  
Author(s):  
Nayang Shan ◽  
Ningshan Li ◽  
Qile Dai ◽  
Lin Hou ◽  
Xiting Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
T Cell ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cox Regression ◽  
Patient Survival ◽  
Significant Difference

Effector CD8+ T cell activation and its cytotoxic function are positively correlated with improved survival in breast cancer. tRNA-derived fragments (tRFs) have recently been found to be involved in gene regulation in cancer progression. However, it is unclear how interactions between expression of tRFs and T cell activation affect breast cancer patient survival. We used Kaplan–Meier survival and multivariate Cox regression models to evaluate the effect of interactions between expression of tRFs and T cell activation on survival in 1081 breast cancer patients. Spearman correlation analysis and weighted gene co-expression network analysis were conducted to identify genes and pathways that were associated with tRFs. tRFdb-5024a, 5P_tRNA-Leu-CAA-4-1, and ts-49 were positively associated with overall survival, while ts-34 and ts-58 were negatively associated with overall survival. Significant interactions were detected between T cell activation and ts-34 and ts-49. In the T cell exhaustion group, patients with a low level of ts-34 or a high level of ts-49 showed improved survival. In contrast, there was no significant difference in the activation group. Breast cancer related pathways were identified for the five tRFs. In conclusion, the identified five tRFs associated with overall survival may serve as therapeutic targets and improve immunotherapy in breast cancer.

scholarly journals A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival

PLoS Genetics ◽  
2019 ◽  
Vol 15 (12) ◽  
pp. e1008482
Author(s):  
Rodrigo Guarischi-Sousa ◽  
Jhonatas S. Monteiro ◽  
Lilian C. Alecrim ◽  
Jussara S. Michaloski ◽  
Laura B. Cardeal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Patient Survival ◽  
Pathological Angiogenesis

scholarly journals Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nishanth Ulhas Nair ◽  
Avinash Das ◽  
Vasiliki-Maria Rogkoti ◽  
Michiel Fokkelman ◽  
Richard Marcotte ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Patient Survival

scholarly journals Prediction of early breast cancer patient survival using ensembles of hypoxia signatures

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0204123 ◽  
Author(s):  
Inna Y. Gong ◽  
Natalie S. Fox ◽  
Vincent Huang ◽  
Paul C. Boutros
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Early Breast Cancer ◽  
Patient Survival ◽  
Early Breast Cancer Patient
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