scholarly journals Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland

2005 ◽  
Vol 7 (5) ◽  
Author(s):  
Julie R Hens ◽  
John J Wysolmerski
Keyword(s):  
Mammary Gland ◽  
Molecular Mechanisms ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

2020 ◽  
Author(s):  
Molly M. Wilson ◽  
Céline Callens ◽  
Matthieu Le Gallo ◽  
Svetlana Mironov ◽  
Qiong Ding ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Molecular Mechanisms ◽  
Mammary Gland Development ◽  
Epithelial Mesenchymal Transition ◽  
Gene Expression Signature ◽  
Normal Mammary Gland ◽  
Breast Cancers ◽  
Tumor Initiating Cells ◽  
Mesenchymal Transition ◽  
Gland Development

AbstractThe Epithelial–Mesenchymal Transition (EMT) and primary ciliogenesis induce stem cell properties in basal Mammary Stem Cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that EMT transcription factors promote ciliogenesis at intermediate EMT transition states by activating ciliogenesis inducers, including FGFR1. The resulting primary cilia promote BBS11-dependent ubiquitination and inactivation of a central signaling node, GLIS2. We show that GLIS2 inactivation promotes MaSC stemness, and GLIS2 is required for normal mammary gland development. Moreover, GLIS2 inactivation is required to induce the proliferative and tumorigenic capacities of the Mammary-Tumor-initiating cells (MaTICs) of claudin-low breast cancers. Claudin-low breast tumors can be segregated from other breast tumor subtypes based on a GLIS2-dependent gene expression signature. Collectively, our findings establish molecular mechanisms by which EMT programs induce ciliogenesis to control MaSC and MaTIC biology, mammary gland development, and claudin-low breast cancer formation.

Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer

2007 ◽  
Vol 64 (24) ◽  
pp. 3201-3218 ◽  
Author(s):  
E. A. McSherry ◽  
S. Donatello ◽  
A. M. Hopkins ◽  
S. McDonnell
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Molecular Mechanisms ◽  
Mammary Gland Development ◽  
Gland Development

Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer

2007 ◽  
Vol 64 (24) ◽  
pp. 3159-3184 ◽  
Author(s):  
F. Lanigan ◽  
D. O’Connor ◽  
F. Martin ◽  
W. M. Gallagher
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Molecular Mechanisms ◽  
Mammary Gland Development ◽  
Gland Development
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