scholarly journals High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area

2005 ◽  
Vol 7 (5) ◽  
Author(s):  
Petr Pohlreich ◽  
Michal Zikan ◽  
Jana Stribrna ◽  
Zdenek Kleibl ◽  
Marketa Janatova ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Brca1 Gene ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer

Mutations in the BRCA1 gene in it alian breast and ovarian cancer patients

1997 ◽  
Vol 33 ◽  
pp. S9
Author(s):  
L. Ottini ◽  
C. D’Amico ◽  
C. Noviello ◽  
C. Pizzi ◽  
S. Lauro ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Brca1 Gene ◽  
Breast And Ovarian Cancer

scholarly journals Challenges in Interpreting Germline Mutations in BARD1 and ATM in Breast and Ovarian Cancer Patients

2017 ◽  
Vol 23 (4) ◽  
pp. 461-464 ◽  
Author(s):  
Kimberly DeLeonardis ◽  
Kristin Sedgwick ◽  
Olga Voznesensky ◽  
Ellen Matloff ◽  
Erin Hofstatter ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer

High prevalence of deleterious BRCA1 and BRCA2 germline mutations in arab breast and ovarian cancer patients

2018 ◽  
Vol 168 (3) ◽  
pp. 695-702 ◽  
Author(s):  
Al-Joharah Alhuqail ◽  
Areej Alzahrani ◽  
Hannah Almubarak ◽  
Sarah Al-Qadheeb ◽  
Lamyaa Alghofaili ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer ◽  
Brca1 And Brca2 ◽  
High Prevalence

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients

2011 ◽  
Vol 33 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Ella R. Thompson ◽  
Samantha E. Boyle ◽  
Julie Johnson ◽  
Georgina L. Ryland ◽  
Sarah Sawyer ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer ◽  
High Risk Breast

Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation

1995 ◽  
Vol 4 (10) ◽  
pp. 1953-1956 ◽  
Author(s):  
Mieko Matsushima ◽  
Kanji Kobayashi ◽  
Mitsuru Eml ◽  
Junko Saito ◽  
Kaoru Suzumori ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Somatic Mutation ◽  
Mutation Analysis ◽  
Brca1 Gene ◽  
Germline Mutations

scholarly journals RAD51C germline mutations in breast and ovarian cancer patients

2010 ◽  
Vol 12 (4) ◽  
Author(s):  
Mohammad R Akbari ◽  
Patricia Tonin ◽  
William D Foulkes ◽  
Parviz Ghadirian ◽  
Marc Tischkowitz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer

scholarly journals Frequency of BRCA1 Mutations in B&H Breast and Ovarian Cancer Patients

2018 ◽  
Vol 2 (1) ◽  
pp. 49
Author(s):  
Naida Lojo-Kadric ◽  
Lejla Pojskic ◽  
Jasmin Ramic ◽  
Naris Pojskic ◽  
Nurija Bilalovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Cancer Patients ◽  
Statistical Tests ◽  
Brca1 Gene ◽  
Age At Diagnosis ◽  
Genomic Rearrangements ◽  
Cancer Type ◽  
Breast And Ovarian Cancer ◽  
Brca1 Mutations

Incidence of breast cancer ranges from 27 per 100,000 in Middle Africa and Eastern Asia to 92 per 100,000 in Northern America. It is the fifth most common cause of death from cancer in women, with an estimated 522,000 deaths per year (6.4% of the total). Autosomal dominant inheritance of these cancers is characterized by transmission of cancer predisposition from generation to generation, with around 5-10% of all breast cancers being associated with inherited mutations in BRCA1, BRCA2 and other genes.  Breast and ovarian cancers are strongly associated with BRCA1 and BRCA2 mutations. In this study, we genotyped BRCA1 gene for large genomic rearrangements in breast and ovarian cancer patients from Bosnia and Herzegovina, with aim to assess frequency of large BRCA1 mutations (exon deletions/duplications) in this group. We collected 59 breast cancer samples, as well as other data concerning patients’ histopathological parameters of tumor, like age at diagnosis, cancer type, TNM class, cancer grade, as well as estrogen, progesterone and Her2/neu expression. Following DNA extraction from breast cancer samples (tissue after biopsy), BRCA1 mutations were identified by Multiplex Ligase - Dependent Probe Amplification (MLPA) analysis. Biostatistical analyses were conducted using MedCalc v.9.2.0.0 software. In all statistical tests p<0.05 was considered significant. Mean age at diagnosis was 54±1.75 (range 17 – 80). BRCA1 genomic rearrangements were found in 22% of breast and ovarian cancer patients. Statistically significant associations and correlations were found between BRCA1 genomic rearrangements and cancer type, estrogen, progesterone and Her2/neu expression, but not cancer grade, size, invasiveness or patients’ age

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

1995 ◽  
Vol 11 (4) ◽  
pp. 428-433 ◽  
Author(s):  
Simon A. Gayther ◽  
William Warren ◽  
Sylvie Mazoyer ◽  
Paul A. Russell ◽  
Patricia A. Harrington ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Brca1 Gene ◽  
Germline Mutations ◽  
Phenotype Correlation ◽  
Breast And Ovarian Cancer ◽  
Genotype Phenotype Correlation
Sign in / Sign up

Export Citation Format

Share Document