scholarly journals HER2 upregulates fatty acid synthase and acetyl-CoA carboxylase at a translational level in breast cancer cells

2005 ◽  
Vol 7 (S2) ◽  
Author(s):  
S Yoon ◽  
M-Y Lee ◽  
B-W Park ◽  
K-S Kim
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Fatty Acid Synthase ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Translational Level

scholarly journals Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1132
Author(s):  
Javier A. Menendez ◽  
Adriana Papadimitropoulou ◽  
Travis Vander Steen ◽  
Elisabet Cuyàs ◽  
Bharvi P. Oza-Gajera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Promoter Activity ◽  
Fatty Acid Synthase ◽  
Endocrine Resistance ◽  
Gene Promoter ◽  
Her2 Positive ◽  
Her2 Breast Cancer

The identification of clinically important molecular mechanisms driving endocrine resistance is a priority in estrogen receptor-positive (ER+) breast cancer. Although both genomic and non-genomic cross-talk between the ER and growth factor receptors such as human epidermal growth factor receptor 2 (HER2) has frequently been associated with both experimental and clinical endocrine therapy resistance, combined targeting of ER and HER2 has failed to improve overall survival in endocrine non-responsive disease. Herein, we questioned the role of fatty acid synthase (FASN), a lipogenic enzyme linked to HER2-driven breast cancer aggressiveness, in the development and maintenance of hormone-independent growth and resistance to anti-estrogens in ER/HER2-positive (ER+/HER2+) breast cancer. The stimulatory effects of estradiol on FASN gene promoter activity and protein expression were blunted by anti-estrogens in endocrine-responsive breast cancer cells. Conversely, an AKT/MAPK-related constitutive hyperactivation of FASN gene promoter activity was unaltered in response to estradiol in non-endocrine responsive ER+/HER2+ breast cancer cells, and could be further enhanced by tamoxifen. Pharmacological blockade with structurally and mechanistically unrelated FASN inhibitors fully impeded the strong stimulatory activity of tamoxifen on the soft-agar colony forming capacity—an in vitro metric of tumorigenicity—of ER+/HER2+ breast cancer cells. In vivo treatment with a FASN inhibitor completely prevented the agonistic tumor-promoting activity of tamoxifen and fully restored its estrogen antagonist properties against ER/HER2-positive xenograft tumors in mice. Functional cancer proteomic data from The Cancer Proteome Atlas (TCPA) revealed that the ER+/HER2+ subtype was the highest FASN protein expressor compared to basal-like, HER2-enriched, and ER+/HER2-negative breast cancer groups. FASN is a biological determinant of HER2-driven endocrine resistance in ER+ breast cancer. Next-generation, clinical-grade FASN inhibitors may be therapeutically relevant to countering resistance to tamoxifen in FASN-overexpressing ER+/HER2+ breast carcinomas.

scholarly journals Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells

2010 ◽  
Vol 12 (6) ◽  
Author(s):  
Quanri Jin ◽  
Linda X Yuan ◽  
Delphine Boulbes ◽  
Jong Min Baek ◽  
Ying Nai Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Breast Cancer Cells ◽  
Fatty Acid Synthase ◽  
Novel Therapeutic

Identification of human acetyl-CoA carboxylase isozymes in tissue and in breast cancer cells

1994 ◽  
Vol 26 (4) ◽  
pp. 589-594 ◽  
Author(s):  
Lee A. Witters ◽  
Jane Widder ◽  
Aimeenicole King ◽  
Kathy Fassihi ◽  
Francis Kuhajda
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa

scholarly journals Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells

2006 ◽  
Vol 66 (11) ◽  
pp. 5934-5940 ◽  
Author(s):  
Sucharita Bandyopadhyay ◽  
Rui Zhan ◽  
Ying Wang ◽  
Sudha K. Pai ◽  
Shigeru Hirota ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Fatty Acid Synthase

scholarly journals Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase

Oncotarget ◽  
2016 ◽  
Vol 7 (39) ◽  
pp. 63679-63689 ◽  
Author(s):  
Fei Xiao ◽  
Chunxia Wang ◽  
Hongkun Yin ◽  
Junjie Yu ◽  
Shanghai Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Fatty Acid Synthase ◽  
Human Breast Cancer Cells ◽  
Human Breast
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