scholarly journals c-erbB2 and topoisomerase IIα protein expression independently predict poor survival in primary human breast cancer: a retrospective study

2005 ◽  
Vol 7 (3) ◽  
Author(s):  
Peter Fritz ◽  
Cristina M Cabrera ◽  
Jürgen Dippon ◽  
Andreas Gerteis ◽  
Wolfgang Simon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Protein Expression ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Poor Survival ◽  
Topoisomerase Iiα ◽  
Primary Human Breast

Expression of bone sialoprotein in primary human breast cancer is associated with poor survival

1996 ◽  
Vol 69 (4) ◽  
pp. 350-353 ◽  
Author(s):  
Akeila Bellahcène ◽  
Sylvie Menard ◽  
Rosaria Bufalino ◽  
Louis Moreau ◽  
Vincent Castronovo
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Bone Sialoprotein ◽  
Human Breast ◽  
Poor Survival ◽  
Primary Human Breast

Steroid hormone receptor activity of primary human breast cancer and pattern of first metastasis

1991 ◽  
Vol 18 (1) ◽  
pp. 27-32 ◽  
Author(s):  
P. G. Koenders ◽  
L. V. A. M. Beex ◽  
R. Langens ◽  
P. W. C. Kloppenborg ◽  
A. G. H. Smals ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
Steroid Hormone ◽  
Receptor Activity ◽  
Steroid Hormone Receptor ◽  
Human Breast ◽  
Primary Human Breast

scholarly journals c-erbB-4 protein expression in human breast cancer

2000 ◽  
Vol 82 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
T Y Kew ◽  
J A Bell ◽  
S E Pinder ◽  
H Denley ◽  
R Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Expression ◽  
Human Breast Cancer ◽  
Human Breast

Relation between ER and EGFR in primary human breast cancer reports at variance

1990 ◽  
Vol 26 (2) ◽  
pp. 183
Author(s):  
P.G. Koendore ◽  
L.V.A.M. Beex ◽  
J.A. Foekens ◽  
Th.J. Benraad
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Primary Human Breast

scholarly journals Characterization of organoid cultured human breast cancer

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Nadine Goldhammer ◽  
Jiyoung Kim ◽  
Vera Timmermans-Wielenga ◽  
Ole William Petersen
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Human Breast Cancer ◽  
Breast Cancers ◽  
Basal Cells ◽  
Human Breast ◽  
Contemporary Culture ◽  
Mucin 1 ◽  
Organoid Cultures ◽  
Primary Human Breast

AbstractOrganoid cultures are increasingly used to model human cancers experimentally with a view to tailoring personalized medicine and predicting drug responses. Breast cancer is no exception, but in particular, primary breast cancer poses some inherent difficulties due to the frequent presence of residual non-malignant cells in the biopsies. We originally developed an assay for the distinction between malignant and non-malignant structures in primary breast cancer organoid cultures (Petersen et al., Proc Natl Acad Sci (USA) 89(19):9064–8, 1992). Here, we apply this assay to assess the frequency of normal-like organoids in primary breast carcinoma cultures and the cellular composition as a consequence of passaging. We find that in consecutively collected samples of primary human breast cancers, residual non-malignant tissues were observed histologically in five out of ten biopsies. Based on relevant morphogenesis and correct polarization as recorded by expression in luminal epithelial cells of mucin 1 (Muc1), occludin, and keratin 19 (K19) and expression in basal cells of integrin β4, p63, and K14, non-malignant organoids were present in all primary human breast cancer-derived cultures. Furthermore, passaging in a contemporary culture medium was in favor of the selective expansion of basal-like cells. We conclude that organoid cultures of human breast cancers are most representative of the tissue origin in primary culture.

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