scholarly journals Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate

2013 ◽  
Vol 15 (6) ◽  
pp. R205 ◽  
Author(s):  
Shankar Revu ◽  
Petra Neregård ◽  
Erik af Klint ◽  
Marina Korotkova ◽  
Anca Catrina
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Membrane ◽  
Bone Markers ◽  
High Expression

Distribution of T-cell receptor-bearing lymphocytes in the synovial membrane from patients with rheumatoid arthritis

1990 ◽  
Vol 3 (6) ◽  
pp. 737-745 ◽  
Author(s):  
I CHAOUNI ◽  
M RADAL ◽  
J SIMONYLAFONTAINE ◽  
B COMBE ◽  
J SANY ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
T Cell Receptor ◽  
Synovial Membrane ◽  
Cell Receptor

Scoring of Synovial Membrane Hypertrophy and Bone Erosions by MR Imaging in Clinically Active and Inactive Rheumatoid Arthritis of the Wrist

1995 ◽  
Vol 24 (4) ◽  
pp. 212-218 ◽  
Author(s):  
M. Østergaard ◽  
P. Gideon ◽  
K. Ssrensen ◽  
M. Hansen ◽  
M. Stoltenberg ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mr Imaging ◽  
Synovial Membrane ◽  
Bone Erosions

IgG Glycosylation Changes and MBL2 Polymorphisms: Associations with Markers of Systemic Inflammation and Joint Destruction in Rheumatoid Arthritis

2012 ◽  
Vol 39 (3) ◽  
pp. 463-469 ◽  
Author(s):  
LONE N. TROELSEN ◽  
SØREN JACOBSEN ◽  
JODIE L. ABRAHAMS ◽  
LOUISE ROYLE ◽  
PAULINE M. RUDD ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Inflammation ◽  
Joint Destruction ◽  
Serum Levels ◽  
High Expression ◽  
Markers Of Inflammation ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Factor Α ◽  
Igg Glycosylation

Objective.To examine whether IgG glycosylation changes and MBL2 genotypes are associated with systemic inflammation and joint destruction in rheumatoid arthritis (RA).Methods.IgG N-glycan content was determined from serum in 118 patients with RA by high-throughput glycan analysis using normal-phase high-pressure liquid chromatography. MBL2 extended genotypes (YA/YA, YA/XA, XA/XA, YA/YO, XA/YO, YO/YO) were determined. Systemic inflammation was assessed by serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α). Joint destruction was assessed by total Sharp score (TSS) and alloplastic surgery records.Results.IgG hypogalactosylation was significantly correlated to IL-6 (Spearman’s rho = 0.32, p < 0.001), CRP (Spearman’s rho = 0.31, p < 0.001), TSS (Spearman’s rho = 0.25, p = 0.01), and alloplastic replacement of joints (Spearman’s rho = 0.18, p = 0.05). In multivariate analysis including age, CRP, anticitrullinated protein antibodies (ACPA), and other confounders, IgG hypogalactosylation was significantly associated with TSS (p = 0.014) and alloplastic joint replacement (OR 76.5, p = 0.041) in patients homozygous for the high expression MBL2 genotype YA/YA, but not in carriers of lower expression genotypes.Conclusion.Decreased galactosylation of IgG correlated to markers of inflammation, i.e., IL-6 and CRP. Only in patients homozygous for high expression of the MBL2 genotype YA/YA was IgG hypogalactosylation associated with markers of joint destruction. Our results suggest that inflammation-associated decreased galactosylation of IgG combined with high expression MBL2 genotypes are involved in the pathophysiology of RA.

scholarly journals Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane

Reumatismo ◽  
2011 ◽  
Vol 54 (2) ◽  
Author(s):  
F. Ingegnoli ◽  
M. Blades ◽  
A. Manzo ◽  
S. Wahid ◽  
M. Perretti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Migration ◽  
Synovial Membrane ◽  
Scid Mice ◽  
In Vivo Studies
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