scholarly journals Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis

2013 ◽  
Vol 15 (5) ◽  
pp. R165 ◽  
Author(s):  
Mirko Manetti ◽  
Serena Guiducci ◽  
Eloisa Romano ◽  
Jérôme Avouac ◽  
Irene Rosa ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
Potential Contribution ◽  
Impaired Angiogenesis

THU0059 Decreased Expression of Neuropilin-1 in Systemic Sclerosis: Potential Contribution to Impaired Angiogenesis

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A183.3-A183
Author(s):  
E. Romano ◽  
M. Manetti ◽  
C. Mazzotta ◽  
I. J. da Silva Cora ◽  
S. Bellando-Randone ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Potential Contribution ◽  
Neuropilin 1 ◽  
Impaired Angiogenesis

scholarly journals Role of Endothelial to Mesenchymal Transition in the Pathogenesis of the Vascular Alterations in Systemic Sclerosis

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Sergio A. Jimenez
Keyword(s):  
Endothelial Cells ◽  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
Mesenchymal Cell ◽  
Microvascular Endothelial Cell ◽  
Potential Contribution ◽  
Mesenchymal Transition ◽  
Fibrotic Process ◽  
Endothelial To Mesenchymal Transition

The pathogenesis of Systemic Sclerosis (SSc) is extremely complex, and despite extensive studies, the exact mechanisms involved are not well understood. Numerous recent studies of early events in SSc pathogenesis have suggested that unknown etiologic factors in a genetically receptive host trigger structural and functional microvascular endothelial cell abnormalities. These alterations result in the attraction, transmigration, and accumulation of immune and inflammatory cells in the perivascular tissues, which in turn induce the phenotypic conversion of endothelial cells and quiescent fibroblasts into activated myofibroblasts, a process known as endothelial to mesenchymal transition or EndoMT. The activated myofibroblasts are the effector cells responsible for the severe and frequently progressive fibrotic process and the fibroproliferative vasculopathy that are the hallmarks of SSc. Thus, according to this hypothesis the endothelial and vascular alterations, which include the phenotypic conversion of endothelial cells into activated myofibroblasts, play a crucial role in the development of the progressive fibrotic process affecting skin and multiple internal organs. The role of endothelial cell and vascular alterations, the potential contribution of endothelial to mesenchymal cell transition in the pathogenesis of the tissue fibrosis, and fibroproliferative vasculopathy in SSc will be reviewed here.

Impaired Angiogenesis in Systemic Sclerosis: The Emerging Role of the Antiangiogenic VEGF165b Splice Variant

2011 ◽  
Vol 21 (7) ◽  
pp. 204-210 ◽  
Author(s):  
Mirko Manetti ◽  
Serena Guiducci ◽  
Lidia Ibba-Manneschi ◽  
Marco Matucci-Cerinic
Keyword(s):  
Systemic Sclerosis ◽  
Splice Variant ◽  
Impaired Angiogenesis

scholarly journals Anti-endothelial cell antibodies are associated with apoptotic endothelial microparticles, endothelial sloughing and decrease in angiogenic progenitors in systemic sclerosis

2020 ◽  
Vol 37 (5) ◽  
pp. 725-735
Author(s):  
Małgorzata M. Michalska-Jakubus ◽  
Marta Rusek ◽  
Małgorzata Kowal ◽  
Marcin Czop ◽  
Janusz Kocki ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
Endothelial Microparticles

scholarly journals Decreased CCN3 in Systemic Sclerosis Endothelial Cells Contributes to Impaired Angiogenesis

2020 ◽  
Vol 140 (7) ◽  
pp. 1427-1434.e5 ◽  
Author(s):  
Pauline Henrot ◽  
François Moisan ◽  
Paôline Laurent ◽  
Pauline Manicki ◽  
Priscilla Kaulanjan-Checkmodine ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Systemic Sclerosis ◽  
Impaired Angiogenesis

A potential contribution of decreased galectin‐7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis

2019 ◽  
Vol 28 (5) ◽  
pp. 536-542 ◽  
Author(s):  
Ryosuke Saigusa ◽  
Takashi Yamashita ◽  
Shunsuke Miura ◽  
Megumi Hirabayashi ◽  
Kouki Nakamura ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Potential Contribution ◽  
Stratified Epithelia

scholarly journals Systemic Sclerosis-Endothelial Cell Antiangiogenic Pentraxin 3 and Matrix Metalloprotease 12 Control Human Breast Cancer Tumor Vascularization and Development in Mice

Neoplasia ◽  
2009 ◽  
Vol 11 (10) ◽  
pp. 1106-1115 ◽  
Author(s):  
Francesca Margheri ◽  
Simona Serratì ◽  
Andrea Lapucci ◽  
Chillà Anastasia ◽  
Betti Giusti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
Human Breast Cancer ◽  
Pentraxin 3 ◽  
Matrix Metalloprotease ◽  
Human Breast ◽  
Tumor Vascularization ◽  
Cancer Tumor

scholarly journals The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Theresa C. Barnes ◽  
Marina E. Anderson ◽  
Robert J. Moots
Keyword(s):  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
Interleukin 6 ◽  
Signalling Pathways ◽  
Endothelial Cell Dysfunction ◽  
Potential Therapeutic Target ◽  
Cell Dysfunction ◽  
Significant Interest ◽  
The Many

Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial cell dysfunction, and fibrogenesis is discussed. The existing evidence that interventions designed to block interleukin-6 signalling are of therapeutic relevance in SSc is evaluated.

scholarly journals Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

2020 ◽  
Vol 130 (5) ◽  
pp. 2451-2464 ◽  
Author(s):  
Takashi Maehara ◽  
Naoki Kaneko ◽  
Cory A. Perugino ◽  
Hamid Mattoo ◽  
Jesper Kers, ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Endothelial Cell ◽  
T Lymphocytes ◽  
Cell Apoptosis ◽  
Endothelial Cell Apoptosis

scholarly journals The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis

2020 ◽  
Vol 21 (10) ◽  
pp. 3633 ◽  
Author(s):  
Khalia R. Primer ◽  
Peter J. Psaltis ◽  
Joanne T.M. Tan ◽  
Christina A. Bursill
Keyword(s):  
Endothelial Cell ◽  
Cell Metabolism ◽  
High Density ◽  
Metabolic Reprogramming ◽  
High Density Lipoproteins ◽  
Impaired Wound Healing ◽  
Endothelial Cell Function ◽  
Positive Effects ◽  
Impaired Angiogenesis ◽  
Endothelial Cell Metabolism

Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing evidence that high-density lipoproteins (HDL) can rescue diabetes-impaired angiogenesis through a number of mechanisms, including the modulation of endothelial cell metabolic reprogramming. Endothelial cell metabolic reprogramming in response to tissue ischaemia is a driver of angiogenesis and is dysregulated by diabetes. Specifically, diabetes impairs pathways that allow endothelial cells to upregulate glycolysis in response to hypoxia adequately and impairs suppression of mitochondrial respiration. HDL rescues the impairment of the central hypoxia signalling pathway, which regulates these metabolic changes, and this may underpin several of its known pro-angiogenic effects. This review discusses the current understanding of endothelial cell metabolism and how diabetes leads to its dysregulation whilst examining the various positive effects of HDL on endothelial cell function.

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