scholarly journals Functional outcome and prognostic factors in anti-Jo1 patients with antisynthetase syndrome

2013 ◽  
Vol 15 (5) ◽  
pp. R149 ◽  
Author(s):  
Isabelle Marie ◽  
Pierre-Yves Hatron ◽  
Patrick Cherin ◽  
Eric Hachulla ◽  
Elisabeth Diot ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Functional Outcome ◽  
Antisynthetase Syndrome

Factors Affecting Functional Outcome in Patients with Nontraumatic Spinal Cord Lesions After Inpatient Rehabilitation

2001 ◽  
Vol 15 (2) ◽  
pp. 99-104 ◽  
Author(s):  
J.J.M.F. van der Putten ◽  
V.L. Stevenson ◽  
E.D. Playford ◽  
A.J. Thompson
Keyword(s):  
Spinal Cord ◽  
Regression Analysis ◽  
Prognostic Factors ◽  
Functional Outcome ◽  
Symptom Onset ◽  
Spinal Cord Lesion ◽  
Functional Improvement ◽  
Motor Score ◽  
Spinal Cord Lesions ◽  
Cord Lesion

Objective: Patients with nontraumatic spinal cord lesions account for between one fourth and one half of all spinal cord injuries. In the management of this group of patients, an understanding of factors influencing functional improvement is essen tial to help define the most appropriate rehabilitation programme. Although it is pos sible to predict accurately the functional outcome for an individual patient with a com plete traumatic spinal cord injury, few studies have looked at prognostic factors in patients with nontraumatic spinal cord disease. The aim of this study was to determine which, and how well, factors assessed on admission to a rehabilitation unit relate to functional improvement in this group. Methods: The study sample consists of 100 patients with an incomplete nontraumatic spinal cord lesion who underwent inpatient neurorehabilitation. Possible prognostic factors were sought by identifying those vari ables with a significant difference in the Functional Independence Measure (FIM) motor change score above and below the median. A step-wise multiple regression analysis was then performed to determine which variables influenced functional out come. Results: Patients with larger functional gains had significantly lower disability scores on admission, a shorter time between symptom onset and rehabilitation, and a longer length of stay. They were more likely to have a cervical lesion and evidence of neurologic recovery. Multiple regression analysis demonstrated that the FIM motor score on admission and the time between symptom onset and rehabilitation predicted 54% of the variance of the FIM motor score gain. Conclusions: This finding suggests that early rehabilitation is an important factor in securing a good outcome. Key Words: Rehabilitation-Spinal cord lesion-Functional outcome.

scholarly journals Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma—An Unrecognized Prognostic Factor

2020 ◽  
Vol 10 ◽  
Author(s):  
Patrick Schuss ◽  
Felix Lehmann ◽  
Niklas Schäfer ◽  
Christian Bode ◽  
Elisa Scharnböck ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Functional Outcome ◽  
Prolonged Mechanical Ventilation ◽  
Methylation Status ◽  
Significant Prognostic Factor ◽  
Karnofsky Performance Score ◽  
Newly Diagnosed ◽  
Newly Diagnosed Glioblastoma

ObjectiveAlthough the treatment of glioblastoma patients is well established in neuro-oncological surgery, precious scarce data is available on patients with glioblastoma requiring postoperative prolonged mechanical ventilation (PMV). Therefore, the aim of the present study was to determine the influence of PMV on overall survival (OS) in patients with glioblastoma.MethodsPatients with newly diagnosed glioblastoma who had undergone surgical therapy and complete subsequent neuro-oncological treatment at the authors’ neuro-oncological center from January 2013 to December 2018 were selected and included in the further analysis. PMV was defined as mechanical ventilation for more than 24 h after surgery. Survival analyses were performed, including established prognostic factors such as age, Karnofsky performance score, MGMT-promoter methylation status and extent of resection.ResultsA total of 240 patients with newly diagnosed glioblastoma and subsequent surgical treatment were identified. 13 patients (5%) suffered from PMV during the treatment course of glioblastoma. All but one patient were successfully weaned from mechanical ventilation. Patients suffering from PMV achieved significantly less often favorable functional outcome after 3, 6, 9, and 12 months compared to patients without PMV. Multivariate analysis revealed PMV to constitute a significant prognostic factor for OS, independent of other prognostic factors (p<0.0001, OR 6.7, 95% CI 3.2–13.8).ConclusionsThe present study identifies PMV as significantly associated with impaired functional outcome and poor OS in patients suffering from newly diagnosed glioblastoma. These findings encourage further efforts to investigate/assess this prognostic factor in future studies.

Prognostic Factors Influencing the Functional Outcome of Total Hip Arthroplasty for Hip Infection Sequelae

2005 ◽  
Vol 20 (5) ◽  
pp. 608-613 ◽  
Author(s):  
Youn-Soo Park ◽  
Young-Wan Moon ◽  
Seung-Jae Lim ◽  
Irvin Oh ◽  
Ji-Soon Lim
Keyword(s):  
Prognostic Factors ◽  
Total Hip Arthroplasty ◽  
Functional Outcome ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
Factors Influencing ◽  
Hip Infection

Single-stage posterior decompression and stabilization for metastasis of the thoracic spine: prognostic factors for functional outcome and patients' survival

2012 ◽  
Vol 12 (12) ◽  
pp. 1083-1092 ◽  
Author(s):  
Sangjoon Chong ◽  
Sang-Hoon Shin ◽  
Heon Yoo ◽  
Seung Hoon Lee ◽  
Ki-Jeong Kim ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Functional Outcome ◽  
Thoracic Spine ◽  
Single Stage ◽  
Posterior Decompression

Prognostic factors in a cohort of antisynthetase syndrome (ASS): serologic profile is associated with mortality in patients with interstitial lung disease (ILD)

2015 ◽  
Vol 34 (9) ◽  
pp. 1563-1569 ◽  
Author(s):  
Jorge Rojas-Serrano ◽  
Denisse Herrera-Bringas ◽  
Mayra Mejía ◽  
Hermes Rivero ◽  
Heidegger Mateos-Toledo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Antisynthetase Syndrome

scholarly journals Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry

2021 ◽  
Vol 23 (3) ◽  
pp. 401-410
Author(s):  
Salvatore Rudilosso ◽  
José Ríos ◽  
Alejandro Rodríguez ◽  
Meritxell Gomis ◽  
Víctor Vera ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Functional Outcome ◽  
Population Based ◽  
Vessel Occlusion ◽  
Inverse Probability ◽  
The Poor ◽  
Good Functional Outcome ◽  
Stroke Disability ◽  
Population Based Registry ◽  
The Impact

Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups’ criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3).Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.

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