scholarly journals Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply

2013 ◽  
Vol 15 (2) ◽  
pp. 406
Author(s):  
Qin Shi ◽  
Jamilah Abusarah ◽  
Ghayath Baroudi ◽  
Julio C Fernandes ◽  
Hassan Fahmi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Peroxidation ◽  
Experimental Model ◽  
Cardiac Fibrosis

scholarly journals Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis

2012 ◽  
Vol 14 (5) ◽  
pp. R223 ◽  
Author(s):  
Qin Shi ◽  
Jamilah Abusarah ◽  
Ghayath Baroudi ◽  
Julio C Fernandes ◽  
Hassan Fahmi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Peroxidation ◽  
Experimental Model ◽  
Cardiac Fibrosis

scholarly journals Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 45
Author(s):  
Helena Beatriz Ferreira ◽  
Tânia Melo ◽  
Artur Paiva ◽  
Maria do Rosário Domingues
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Inflammatory Responses ◽  
Molecular Level ◽  
Lipid Hydroperoxides ◽  
Lipid Species ◽  
Inflammatory Autoimmune Disease

Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. However, oxidative stress and lipid peroxidation are associated with the development and pathogenesis of RA. In this case, oxidative damage biomarkers have been found to be significantly higher in RA patients, associated with the oxidation of biomolecules and the stimulation of inflammatory responses. Lipid peroxidation is one of the major consequences of oxidative stress, with the formation of deleterious lipid hydroperoxides and electrophilic reactive lipid species. Additionally, changes in the lipoprotein profile seem to be common in RA, contributing to cardiovascular diseases and a chronic inflammatory environment. Nevertheless, changes in the lipid profile at a molecular level in RA are still poorly understood. Therefore, the goal of this review was to gather all the information regarding lipid alterations in RA analyzed by mass spectrometry. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid metabolisms, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.

Lipid peroxidation and lung ultrastructural changes in an experimental model of leukocyte-mediated pulmonary injury

Lung ◽  
1990 ◽  
Vol 168 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Emma Borrelli ◽  
PierPaolo Giomarelli ◽  
Osvaldo Chiara ◽  
Alessandro Casini ◽  
Sandra Betti ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Experimental Model ◽  
Ultrastructural Changes ◽  
Pulmonary Injury

scholarly journals Te anti-rheumatic effect of UFT(uracil-tegafur preparation) for rheumatoid arthritis and its experimental model.

Ensho ◽  
1992 ◽  
Vol 12 (6) ◽  
pp. 553-559
Author(s):  
Akira Yanagawa ◽  
Tadashi Fukumura ◽  
Hideki Matsui ◽  
Keiyu Takano ◽  
Kusuki Nishioka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Experimental Model

scholarly journals Redox Status in Women with Rheumathoid Arthritis

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksandra Vranic ◽  
Aleksandra Antovic ◽  
Nevena Draginic ◽  
Marijana Andjic ◽  
Marko Ravic ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Cartilage Damage ◽  
Thiobarbituric Acid ◽  
Antioxidant Defense System ◽  
Redox Status ◽  
Female Population

Abstract The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation - thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as antioxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased superoxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.

scholarly journals Assessment of lipid peroxidation and antioxidant status in rheumatoid arthritis and osteoarthritis patients

2011 ◽  
Vol 33 (4) ◽  
pp. 179-185 ◽  
Author(s):  
Amal Mohamad El-barbary ◽  
Manal Aly Abdel Khalek ◽  
Alaa Mohamad Elsalawy ◽  
Sahar Mohyeldeen Hazaa
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Peroxidation ◽  
Antioxidant Status

Lipid peroxidation in Rheumatoid arthritis; consequences and monitoring

2014 ◽  
Vol 75 ◽  
pp. S49
Author(s):  
Wojciech Luczaj ◽  
Iwona Jarocka-Karpinska ◽  
Stanislaw Sierakowski ◽  
Luka Andrisic ◽  
Neven Zarkovic ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Peroxidation
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