scholarly journals Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy

2012 ◽  
Vol 14 (4) ◽  
pp. R172 ◽  
Author(s):  
Byung Lee ◽  
Wendy C Carcamo ◽  
John A Chiorini ◽  
Ammon B Peck ◽  
Cuong Q Nguyen
Keyword(s):  
Gene Therapy ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome

Developing a gene therapy for Sjögren’s syndrome

2006 ◽  
Vol 1 (4) ◽  
pp. 433-440 ◽  
Author(s):  
Jelle LG Vosters ◽  
Bruce J Baum ◽  
Paul P Tak ◽  
Gabor G Illei ◽  
John A Chiorini
Keyword(s):  
Gene Therapy ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Development of Autoimmune Exocrinopathy Resembling Sjögren's Syndrome in Estrogen-Deficient Mice of Healthy Background

2003 ◽  
Vol 163 (4) ◽  
pp. 1481-1490 ◽  
Author(s):  
Naozumi Ishimaru ◽  
Rieko Arakaki ◽  
Megumi Watanabe ◽  
Masaru Kobayashi ◽  
Katsushi Miyazaki ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Deficient Mice ◽  
Sjögren‘S Syndrome

scholarly journals Development of autoimmune exocrinopathy resembling Sjögren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells

2003 ◽  
Vol 48 (12) ◽  
pp. 3603-3609 ◽  
Author(s):  
Rieko Arakaki ◽  
Naozumi Ishimaru ◽  
Ichiro Saito ◽  
Masaru Kobayashi ◽  
Natsuo Yasui ◽  
...  
Keyword(s):  
T Cells ◽  
Sjögren’S Syndrome ◽  
Cd4 T Cells ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome

scholarly journals Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

1996 ◽  
Vol 7 (2) ◽  
pp. 144-158 ◽  
Author(s):  
P.C. Fox ◽  
P.M. Speight
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Autoimmune Disorder ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Immune Mediators ◽  
Normal Salivary Gland ◽  
Subsequent Loss ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome

Sjogren's syndrome is a systemic autoimmune disorder characterized by symptoms of oral and ocular dryness and a chronic, progressive loss of salivary and lacrimal function. The exocrine involvement is the result of a focal, peri-ductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells. The mechanisms of this autoimmune exocrinopathy are not understood fully. Many recent investigations have described alterations in a number of immune mediators within the salivary glands. These studies provide new insights into the immune regulation of normal salivary gland functions and the mechanisms of gland damage in Sjogren's syndrome.

scholarly journals Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjögren’s Syndrome

2002 ◽  
Vol 169 (2) ◽  
pp. 1050-1057 ◽  
Author(s):  
Kaoru Saegusa ◽  
Naozumi Ishimaru ◽  
Kumiko Yanagi ◽  
Kenji Mishima ◽  
Rieko Arakaki ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome

Role of complement and B lymphocytes in Sjögren's syndrome-like autoimmune exocrinopathy of NOD.B10-H2b mice

2006 ◽  
Vol 43 (9) ◽  
pp. 1332-1339 ◽  
Author(s):  
Cuong Nguyen ◽  
Janet Cornelius ◽  
Eric Singson ◽  
Smruti Killedar ◽  
Seunghee Cha ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome
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