scholarly journals Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

2012 ◽  
Vol 14 (3) ◽  
pp. R155 ◽  
Author(s):  
Karim Sacre ◽  
Lindsey A Criswell ◽  
Joseph M McCune
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Tumor Necrosis Factor ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha ◽  
Alpha Production ◽  
Factor Alpha ◽  
Necrosis Factor

A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha

1994 ◽  
Vol 24 (1) ◽  
pp. 191-195 ◽  
Author(s):  
Anthony G. Wilson ◽  
Caroline Gordon ◽  
Francesco S. di Giovine ◽  
Niek de Vries ◽  
Leo B. A. van de Putte ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Tumor Necrosis Factor ◽  
Genetic Association ◽  
Tumor Necrosis Factor Alpha ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor alpha promoter polymorphism −308 G/A in Brazilian patients with systemic lupus erythematosus

2012 ◽  
Vol 73 (11) ◽  
pp. 1166-1170 ◽  
Author(s):  
Hildson Dornelas Angelo ◽  
Helker Albuquerque da Silva ◽  
Nadja Maria Jorge Asano ◽  
Maria Tereza Cartaxo Muniz ◽  
Maria de Mascena Diniz Maia ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Promoter Polymorphism ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Mariana Postal ◽  
Aline Tamires Lapa ◽  
Nailú Angélica Sinicato ◽  
Karina de Oliveira Peliçari ◽  
Fernando Augusto Peres ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Depressive Symptoms ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus

2015 ◽  
Vol 76 (8) ◽  
pp. 533-536 ◽  
Author(s):  
Fatemeh Tahghighi ◽  
Vahid Ziaee ◽  
Mohammad Hassan Moradinejad ◽  
Arezou Rezaei ◽  
Sara Harsini ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Necrosis Factor Alpha ◽  
Single Nucleotide ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Familial Aggregation of High Tumor Necrosis Factor Alpha Levels in Systemic Lupus Erythematosus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Dorothy Mangale ◽  
Silvia N. Kariuki ◽  
Beverly S. Chrabot ◽  
Marissa Kumabe ◽  
Jennifer A. Kelly ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tumor Necrosis ◽  
Familial Aggregation ◽  
Recurrence Risk ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha ◽  
First Degree Relatives ◽  
Factor Alpha ◽  
Necrosis Factor

Systemic lupus erythematosus (SLE) patients frequently have high circulating tumor necrosis factor alpha (TNF-α) levels. We explored circulating TNF-αlevels in SLE families to determine whether high levels of TNF-αwere clustered in a heritable pattern. We measured TNF-αin 242 SLE patients, 361 unaffected family members, 23 unaffected spouses of SLE patients, and 62 unrelated healthy controls. Familial correlations and relative recurrence risk rates for the high TNF-αtrait were assessed. SLE-affected individuals had the highest TNF-αlevels, and TNF-αwas significantly higher in unaffected first degree relatives than healthy unrelated subjects(P=0.0025). No Mendelian patterns were observed, but 28.4% of unaffected first degree relatives of SLE patients had high TNF-αlevels, resulting in a first degree relative recurrence risk of 4.48(P=2.9×10-5). Interestingly, the median TNF-αvalue in spouses was similar to that of the first degree relatives. Concordance of the TNF-αtrait (high versus low) in SLE patients and their spouses was strikingly high at 78.2%. These data support a role for TNF-αin SLE pathogenesis, and TNF-αlevels may relate with heritable factors. The high degree of concordance in SLE patients and their spouses suggests that environmental factors may also play a role in the observed familial aggregation.

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