scholarly journals Obesity and carotid atherosclerosis in African black and Caucasian women with established rheumatoid arthritis: a cross-sectional study

2012 ◽  
Vol 14 (2) ◽  
pp. R67 ◽  
Author(s):  
Ahmed Solomon ◽  
Gavin R Norton ◽  
Angela J Woodiwiss ◽  
Patrick H Dessein
Keyword(s):  
Rheumatoid Arthritis ◽  
Carotid Atherosclerosis ◽  
Cross Sectional Study ◽  
Established Rheumatoid Arthritis ◽  
Sectional Study ◽  
Cross Sectional ◽  
African Black ◽  
Caucasian Women

Periodontitis in Italian patients with established rheumatoid arthritis: a cross‐sectional study

Oral Diseases ◽  
2021 ◽  
Author(s):  
Dimitra Karapetsa ◽  
Arianna Consensi ◽  
Giulia Castagnoli ◽  
Morena Petrini ◽  
Matteo Tonelli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cross Sectional Study ◽  
Established Rheumatoid Arthritis ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Cumulative inflammatory burden and obesity as determinants of insulin resistance in patients with established rheumatoid arthritis: cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e044749
Author(s):  
Sara Manrique-Arija ◽  
Natalia Mena-Vazquez ◽  
Inmaculada Ureña ◽  
José Rioja ◽  
Pedro Valdivielso ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Model Assessment ◽  
Established Rheumatoid Arthritis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Burden

ObjectivesTo describe the prevalence of insulin resistance (IR) in patients with established rheumatoid arthritis (RA) and to analyse the contribution of cumulative inflammatory burden and other factors to its development.DesignObservational cross-sectional study.ParticipantsPatients with RA and controls matched for age, sex and Body Mass Index. We excluded patients with diabetes.SettingsPatients from an RA inception cohort at Hospital Regional Universitario de Málaga, Spain, were recruited between September 2016 and May 2018.Primary and secondary outcome measuresIR was evaluated using the homeostasis model assessment for IR and beta-cell function and the quantitative insulin sensitivity check index. Other variables included the cumulative 28-Joint Disease Activity Score (DAS28) with C reactive protein (CRP) body composition and cytokines. Two logistic regression models were constructed to identify factors associated with IR in patients with RA.ResultsEighty-nine patients with RA and 80 controls were included. The prevalence of IR was similar in both cases and controls. Inflammatory activity was controlled appropriately in patients during follow-up (mean DAS28 3.1 (0.8)). The presence of IR in patients with RA was associated with obesity (OR 6.01, 95% CI 1.9 to 8.7), higher cumulative DAS28-CRP values during follow-up (OR 2.8, 95% CI 1.3 to 6.0), and higher interleukin-1β levels (OR 1.6, 95% CI 1.1 to 2.4). The second model showed that the risk of IR increased by 10% for each kilogram of excess body fat.ConclusionIn patients with well-controlled, established RA, IR is associated mainly with poorer control of inflammation from diagnosis and with obesity, specifically total fat mass.

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