scholarly journals Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis

2012 ◽  
Vol 14 (1) ◽  
pp. R28 ◽  
Author(s):  
Scott W Graf ◽  
Sue Lester ◽  
Johannes C Nossent ◽  
Catherine L Hill ◽  
Susanna M Proudman ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Low Copy Number ◽  
Control Study ◽  
Fcgr3b Gene

scholarly journals PTPN22 1858C>T Polymorphism Distribution in Europe and Association with Rheumatoid Arthritis: Case-Control Study and Meta-Analysis

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24292 ◽  
Author(s):  
Michele Ciro Totaro ◽  
Barbara Tolusso ◽  
Valerio Napolioni ◽  
Francesca Faustini ◽  
Silvia Canestri ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Rheumatoid Arthritis Case ◽  
Distribution In Europe ◽  
Control Study

Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: A case-control study and meta-analysis

Autoimmunity ◽  
2016 ◽  
Vol 50 (3) ◽  
pp. 158-169 ◽  
Author(s):  
Sajad Ahmad Dar ◽  
Shafiul Haque ◽  
Raju Kumar Mandal ◽  
Taru Singh ◽  
Mohd Wahid ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

Association of the UCP polymorphisms with susceptibility to obesity: case-control study and meta-analysis

2014 ◽  
Author(s):  
Bianca Souza ◽  
Leticia Brondani ◽  
Tais Assmann ◽  
Ana Paula Boucas ◽  
Andrea Carla Bauer ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study

2018 ◽  
Vol 13 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Francesco Ursini ◽  
Salvatore D`Angelo ◽  
Emilio Russo ◽  
Giorgio Ammerata ◽  
Ludovico Abenavoli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Complement C3 ◽  
Serum Complement ◽  
Control Study

scholarly journals Case–Control Study and Meta-Analysis of the Association Between LIPG rs9958947 SNP and Stroke Risk

2021 ◽  
Author(s):  
Kok Yeow Phneh ◽  
Eric Tzyy Jiann Chong ◽  
Syahiskandar Sybil Shah ◽  
Yuen Kang Chia ◽  
Dayang Maryama Bte Awang Daud ◽  
...  
Keyword(s):  
Stroke Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

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