scholarly journals Transforming growth factor β 869C/T and interleukin 6 -174G/C polymorphisms relate to the severity and progression of bone-erosive damage detected by ultrasound in rheumatoid arthritis

2011 ◽  
Vol 13 (4) ◽  
pp. R111 ◽  
Author(s):  
Fulvia Ceccarelli ◽  
Carlo Perricone ◽  
Martina Fabris ◽  
Cristiano Alessandri ◽  
Annamaria Iagnocco ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Growth Factor ◽  
Interleukin 6 ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-β and interleukin-6

2007 ◽  
Vol 82 (2) ◽  
pp. 354-360 ◽  
Author(s):  
Shih-Jen Liu ◽  
Jy-Ping Tsai ◽  
Chia-Rui Shen ◽  
Yuh-Pyng Sher ◽  
Chia-Ling Hsieh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Interleukin 6 ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Pathogenesis of rheumatoid arthritis

2014 ◽  
Vol 1 (1) ◽  
pp. 8-11
Author(s):  
Bilal Bengana ◽  
◽  
Samy Slimani ◽  
Bachir Hachemi ◽  
◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Bone Destruction ◽  
Joint Inflammation ◽  
Transforming Growth Factor Β ◽  
High Serum ◽  
Autoimmune Reaction ◽  
Systemic Inflammatory Disease

Rheumatoid arthritis is a chronic systemic inflammatory disease of unknown cause. An external trigger (eg, cigarette smoking, infection, or trauma) that triggers an autoimmune reaction, leading to synovial hypertrophy and chronic joint inflammation along with the potential for extra-articular manifestations, is theorized to occur in genetically susceptible individuals. Several genes are implicated including class II major histocompatibility complex genes, PTPN22, and C5-TRAF1. Adaptive and innate immune responses in the synovium have been implicated in the pathogenesis of RA. Evidence of autoimmunity, including high serum levels of autoantibodies such as rheumatoid factors and anticitrullinated peptide antibodies, can be present for many years before the onset of clinical arthritis. Although inciting factors have yet to be identified, the presence and activity of a number of proinflammatory chemokines and cytokines have established roles in disease pathogenesis. The activation and infiltration of T cells and macrophages in the synovium result in the production of interleukin-1, -2, -6, -8, -10, -17; tumor necrosis factor-α (TNF-α); platelet-derived growth factor; insulin-like growth factor; and transforming growth factor β (TGF β). These effector molecules are implicated in synovial tissue inflammation and proliferation, cartilage and bone destruction, and systemic effects.

A Pilot Study Examining Circulating Interleukin-6 and Transforming Growth Factor-β Levels During Pelvic Radiation Therapy

2013 ◽  
Vol 36 (4) ◽  
pp. 344-347
Author(s):  
Christopher L. Hallemeier ◽  
Matt J. Iott ◽  
James A. Martenson ◽  
Michael G. Haddock ◽  
Xinghua (Cathy) Zhao ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pilot Study ◽  
Growth Factor ◽  
Interleukin 6 ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Pelvic Radiation
Sign in / Sign up

Export Citation Format

Share Document