scholarly journals Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis

2010 ◽  
Vol 12 (4) ◽  
pp. R157 ◽  
Author(s):  
Marcelo JU Correa ◽  
Luis EC Andrade ◽  
Cristiane Kayser
Keyword(s):  
Systemic Sclerosis ◽  
Laser Doppler ◽  
Nailfold Capillaroscopy ◽  
Doppler Imaging ◽  
Laser Doppler Imaging

scholarly journals The Place of Nailfold Capillaroscopy Among Instrumental Methods for Assessment of Some Peripheral Ischaemic Syndromes in Rheumatology

Folia Medica ◽  
2016 ◽  
Vol 58 (2) ◽  
pp. 77-88 ◽  
Author(s):  
Sevdalina N. Lambova
Keyword(s):  
Differential Diagnosis ◽  
Systemic Sclerosis ◽  
Doppler Ultrasound ◽  
Predictive Value ◽  
Laser Doppler ◽  
Nailfold Capillaroscopy ◽  
Doppler Imaging ◽  
Peripheral Arteries ◽  
Doppler Flowmetry ◽  
Instrumental Methods

AbstractMicro- and macrovascular pathology is a frequent finding in a number of common rheumatic diseases. Secondary Raynaud’s phenomenon (RP) is among the most common symptoms in systemic sclerosis and several other systemic autoimmune diseases including a broad differential diagnosis. It should be also differential from other peripheral vascular syndromes such as embolism, thrombosis, etc., some of which lead to clinical manifestation of the blue toe syndrome.The current review discusses the instrumental methods for vascular assessments.Nailfold capillaroscopy is the only method among the imaging techniques that can be used for morphological assessment of the nutritive capillaries in the nailfold area. Laser-Doppler flowmetry and laser-Doppler imaging are methods for functional assessment of microcirculation, while thermography and plethysmography reflect both blood flow in peripheral arteries and microcirculation. Doppler ultrasound and angiography visualize peripheral arteries. The choice of the appropriate instrumental method is guided by the clinical presentation. The main role of capillaroscopy is to provide differential diagnosis between primary and secondary RP. In rheumatology, capillaroscopic changes in systemic sclerosis have been recently defined as diagnostic. The appearance of abnormal capillaroscopic pattern inherits high positive predictive value for the development of a connective tissue disease that is higher than the predictive value of antinuclear antibodies. In cases of abrupt onset of peripheral ischaemia, clinical signs of critical ischaemia, unilateral or lower limb involvement, Doppler ultrasound and angiography are indicated. The most common causes for such clinical picture that may be referred to rheumatologic consultation are the antiphospholipid syndrome, mimickers of vasculitides such as atherosclerosis with cholesterol emboli, and neoplasms.

Laser Doppler imaging evaluation of nitroglycerin patch application in systemic sclerosis patients

2020 ◽  
Vol 25 (6) ◽  
pp. 559-568
Author(s):  
Georgiana Pintea Bentea ◽  
Aurélien Wauters ◽  
Jean-Claude Wautrecht ◽  
Elie Cogan
Keyword(s):  
Blood Flow ◽  
Systemic Sclerosis ◽  
Structural Features ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Laser Doppler Imaging ◽  
Imaging Evaluation ◽  
Patch Application ◽  
Hand Temperature ◽  
Cold Challenge

Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch (Trinipatch® 5 mg/24 h) applied to the hand dorsum in patients with SSc using Laser Doppler imaging (LDI) at baseline and following a cold challenge. The study included 21 patients with SSc and 13 controls. Blood flow was evaluated by LDI at the level of the fingertips and metacarpus. Microvascular morphology was evaluated by nailfold capillaroscopy (NC). LDI revealed decreased fingertip baseline perfusion and a stronger vasoconstrictor response to a cold challenge in patients with SSc versus control. Metacarpal application of a NTG patch led to an increase in blood flow and hand temperature in patients with SSc. Furthermore, NTG administration led to a faster reperfusion after cold challenge. Correlation analyses revealed that the magnitude of the vasodilatory response was inversely related to baseline fingertip perfusion and hand temperature, but unrelated to the number of capillaries/mm assessed using NC. In conclusion, we provide evidence of a vasodilatory reaction following NTG patch application in patients with SSc using LDI and a protective effect against cold challenge. The magnitude of the response to NTG was related to functional, but not structural features. Our results support a further evaluation of the NTG patch as a possible therapeutic agent in SSc-associated RP.

scholarly journals Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis

Rheumatology ◽  
2013 ◽  
Vol 53 (1) ◽  
pp. 72-75 ◽  
Author(s):  
D. G. P. Piotto ◽  
M. J. U. Correa ◽  
V. B. Miotto e Silva ◽  
C. Kayser ◽  
M. T. R. A. Terreri
Keyword(s):  
Systemic Sclerosis ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Laser Doppler Imaging ◽  
Juvenile Systemic Sclerosis
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