scholarly journals Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance

2010 ◽  
Vol 12 (3) ◽  
pp. R116 ◽  
Author(s):  
Jade E Hollis-Moffatt ◽  
Michael Chen-Xu ◽  
Ruth Topless ◽  
Nicola Dalbeth ◽  
Peter J Gow ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Association ◽  
Genome Wide ◽  
A Genome ◽  
Caucasian Sample ◽  
Level Of Significance

scholarly journals A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests

2009 ◽  
Vol 3 (Suppl 7) ◽  
pp. S6 ◽  
Author(s):  
Lianfu Chen ◽  
Ming Zhong ◽  
Wei Chen ◽  
Christopher I Amos ◽  
Ruzong Fan
Keyword(s):  
Rheumatoid Arthritis ◽  
Genome Wide Association ◽  
Hotelling's T2 ◽  
Genome Wide ◽  
A Genome ◽  
Hotelling’S T2 ◽  
Rheumatoid Arthritis Data

scholarly journals A genome-wide ordered-subset linkage analysis for rheumatoid arthritis

2007 ◽  
Vol 1 (Suppl 1) ◽  
pp. S101 ◽  
Author(s):  
Desh Mandhyan ◽  
Xana Kim-Howard ◽  
Matthew Gaines ◽  
Swapan K Nath
Keyword(s):  
Rheumatoid Arthritis ◽  
Linkage Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

2014 ◽  
Vol 74 (3) ◽  
pp. e15-e15 ◽  
Author(s):  
L Bossini-Castillo ◽  
C de Kovel ◽  
H Kallberg ◽  
R van ‘t Slot ◽  
A Italiaander ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer’s Disease

2020 ◽  
Vol 16 (13) ◽  
pp. 1163-1174 ◽  
Author(s):  
Jin Li ◽  
Feng Chen ◽  
Qiushi Zhang ◽  
Xianglian Meng ◽  
Xiaohui Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Topological Analysis ◽  
Amyloid Imaging ◽  
Functional Enrichment ◽  
Collective Effects ◽  
Future Research ◽  
Genome Wide ◽  
A Genome

Background: The etiology of Alzheimer’s disease remains poorly understood at the mechanistic level, and genome-wide network-based genetics have the potential to provide new insights into the disease mechanisms. Objective: The study aimed to explore the collective effects of multiple genetic association signals on an AV-45 PET measure, which is a well-known Alzheimer’s disease biomarker, by employing a networ kassisted strategy. Method: First, we took advantage of a dense module search algorithm to identify modules enriched by genetic association signals in a protein-protein interaction network. Next, we performed statistical evaluation to the modules identified by dense module search, including a normalization process to adjust the topological bias in the network, a replication test to ensure the modules were not found randomly , and a permutation test to evaluate unbiased associations between the modules and amyloid imaging phenotype. Finally, topological analysis, module similarity tests and functional enrichment analysis were performed for the identified modules. Results: We identified 24 consensus modules enriched by robust genetic signals in a genome-wide association analysis. The results not only validated several previously reported AD genes (APOE, APP, TOMM40, DDAH1, PARK2, ATP5C1, PVRL2, ELAVL1, ACTN1 and NRF1), but also nominated a few novel genes (ABL1, ABLIM2) that have not been studied in Alzheimer’s disease but have shown associations with other neurodegenerative diseases. Conclusion: The identified genes, consensus modules and enriched pathways may provide important clues to future research on the neurobiology of Alzheimer’s disease and suggest potential therapeutic targets.

scholarly journals Identification ofIRX1as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

2016 ◽  
Vol 68 (6) ◽  
pp. 1384-1391 ◽  
Author(s):  
Antonio Julià ◽  
Francisco Blanco ◽  
Benjamín Fernández-Gutierrez ◽  
Antonio González ◽  
Juan D. Cañete ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Rheumatoid Factor ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Risk Locus
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