Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Fiona E McCann; Andrew C Palfreeman; Melanie Andrews; Dany P Perocheau; Julia J Inglis; Peter Schafer; Marc Feldmann; Richard O Williams; Fionula M Brennan

doi:10.1186/ar3041

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Arthritis Research & Therapy ◽

10.1186/ar3041 ◽

2010 ◽

Vol 12 (3) ◽

pp. R107 ◽

Cited By ~ 90

Author(s):

Fiona E McCann ◽

Andrew C Palfreeman ◽

Melanie Andrews ◽

Dany P Perocheau ◽

Julia J Inglis ◽

...

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Experimental Arthritis ◽

Pde4 Inhibitor ◽

Synovial Cells ◽

Necrosis Factor Alpha ◽

Spontaneous Production ◽

Factor Alpha ◽

Necrosis Factor

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Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha , as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells

Annals of the Rheumatic Diseases ◽

10.1136/ard.57.8.495 ◽

1998 ◽

Vol 57 (8) ◽

pp. 495-499 ◽

Cited By ~ 16

Author(s):

N. Mizushima ◽

H. Kohsaka ◽

N. Miyasaka

Keyword(s):

Rheumatoid Arthritis ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Interleukin 1 ◽

Tumour Necrosis Factor Alpha ◽

Synovial Cells ◽

Necrosis Factor Alpha ◽

Receptor Signalling ◽

Factor Alpha ◽

Necrosis Factor

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Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction

Annals of the Rheumatic Diseases ◽

10.1136/ard.58.2008.i40 ◽

1999 ◽

Vol 58 (Supplement 1) ◽

pp. i40-i48 ◽

Cited By ~ 57

Author(s):

W. B van den Berg ◽

L. A B Joosten ◽

G. Kollias ◽

F. A J van de Loo

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Cartilage Destruction ◽

Tumour Necrosis Factor Alpha ◽

Experimental Arthritis ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor ◽

And Cartilage

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SAMe restores the changes in the proliferation and in the synthesis of fibronectin and proteoglycans induced by tumour necrosis factor alpha on cultured rabbit synovial cells

Rheumatology ◽

10.1093/rheumatology/36.1.27 ◽

1997 ◽

Vol 36 (1) ◽

pp. 27-31 ◽

Cited By ~ 9

Author(s):

S. Gutierrez ◽

I. Palacios ◽

O. Sanchez-Pernaute ◽

P. Hernandez ◽

J. Moreno ◽

...

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Synovial Cells ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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Expression of matrix metalloproteinase-9 and tumour necrosis factor-alpha in the synovial cells of patients with meniscus tears

Folia Morphologica ◽

10.5603/fm.a2018.0096 ◽

2019 ◽

Vol 78 (3) ◽

pp. 535-544

Author(s):

R. Atiç ◽

E. Deveci

Keyword(s):

Matrix Metalloproteinase ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Synovial Cells ◽

Necrosis Factor Alpha ◽

Meniscus Tears ◽

Factor Alpha ◽

Metalloproteinase 9 ◽

Necrosis Factor

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Short-term histopathological response to anti-tumour necrosis factor alpha therapy in patients with ulcerative colitis

10.26226/morressier.596dfd59d462b80292387586 ◽

2017 ◽

Author(s):

Diana-Alexandra Costache

Keyword(s):

Ulcerative Colitis ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Short Term ◽

Histopathological Response ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Alpha Therapy ◽

Necrosis Factor

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Faculty Opinions recommendation of A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1120210.576363 ◽

2008 ◽

Author(s):

John Atkinson

Keyword(s):

Tumour Necrosis Factor ◽

Interleukin 6 ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Necrosis Factor Alpha ◽

Cord Factor ◽

Factor Alpha ◽

Necrosis Factor ◽

Granulomatous Response

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Faculty Opinions recommendation of Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1162910.623534 ◽

2009 ◽

Author(s):

Ulf Müller-Ladner

Keyword(s):

Tumour Necrosis Factor ◽

Dose Escalation ◽

Inflammatory Arthritis ◽

Tumour Necrosis ◽

Phase 1 ◽

Tumour Necrosis Factor Alpha ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Alpha Antagonist ◽

Necrosis Factor

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Faculty Opinions recommendation of Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2695956.2359056 ◽

2010 ◽

Author(s):

Scott Davies

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Fungal Infections ◽

Tumour Necrosis Factor Alpha ◽

Inhibitor Therapy ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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Tumour necrosis factor-alpha polymorphism -308 G/a and its protein in subjects with gingivitis

Acta Odontologica Scandinavica ◽

10.1080/00016357.2021.1928280 ◽

2021 ◽

pp. 1-6

Author(s):

Julieta Sarai Becerra-Ruiz ◽

Saúl Ramírez-De los Santos ◽

Carmen Celina Alonso-Sánchez ◽

Fernando Martínez-Esquivias ◽

Luz Andrea Martínez-Pérez ◽

...

Keyword(s):

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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Inhibition of Matrix Metalloproteinases-2/-9 Transiently Reduces Pre-Oligodendrocyte Loss during Lipopolysaccharide- but Not Tumour Necrosis Factor-alpha-Induced Inflammation in Fetal Ovine Glial Culture

Developmental Neuroscience ◽

10.1159/000354862 ◽

2013 ◽

Vol 35 (6) ◽

pp. 461-473 ◽

Cited By ~ 2

Author(s):

Luke Weaver-Mikaere ◽

Alistair J. Gunn ◽

Laura Bennet ◽

Murray D. Mitchell ◽

Mhoyra Fraser

Keyword(s):

Matrix Metalloproteinases ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Alpha ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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