scholarly journals Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region

2008 ◽  
Vol 10 (5) ◽  
pp. R113 ◽  
Author(s):  
Aya Kawasaki ◽  
Ikue Ito ◽  
Koki Hikami ◽  
Jun Ohashi ◽  
Taichi Hayashi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Association Study ◽  
Lupus Erythematosus ◽  
Japanese Population ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Association

scholarly journals Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

2016 ◽  
Vol 68 (4) ◽  
pp. 932-943 ◽  
Author(s):  
Marta E. Alarcón-Riquelme ◽  
Julie T. Ziegler ◽  
Julio Molineros ◽  
Timothy D. Howard ◽  
Andrés Moreno-Estrada ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Association Study ◽  
Lupus Erythematosus ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Systemic Lupus ◽  
Genome Wide

scholarly journals Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

2009 ◽  
Vol 69 (2) ◽  
pp. 368-373 ◽  
Author(s):  
K Nishimoto ◽  
Y Kochi ◽  
K Ikari ◽  
K Yamamoto ◽  
A Suzuki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Association Study ◽  
Lupus Erythematosus ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Control Series ◽  
Significant Difference ◽  
And Control

Objective:The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed.Methods:A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay.Results:Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio  = 1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetate-stimulated lymphoblastoid cell lines (p = 0.04).Conclusion:Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.

Association ofIRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: Support for a crucial role of intron 1 polymorphisms

2008 ◽  
Vol 58 (3) ◽  
pp. 826-834 ◽  
Author(s):  
Aya Kawasaki ◽  
Chieko Kyogoku ◽  
Jun Ohashi ◽  
Risa Miyashita ◽  
Koki Hikami ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Crucial Role ◽  
Japanese Population ◽  
Systemic Lupus ◽  
Intron 1

The role of microRNAs (MiR-125a and MiR-146a), RANTES, and IFN-γin systemic lupus erythematosus

2020 ◽  
Vol 23 (13) ◽  
Author(s):  
Ikram khazal Qasim Al- hasso ◽  
Aida Rashid Al- Derzi ◽  
Ahmed Abdul-hassan Abbas ◽  
Faiq I. Gorial ◽  
Ahmed Sameer Alnuimi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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