scholarly journals Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

2008 ◽  
Vol 10 (5) ◽  
pp. 216 ◽  
Author(s):  
Stefan K Drexler ◽  
Philip L Kong ◽  
Jeremy Wales ◽  
Brian M Foxwell
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Signalling ◽  
Innate Immune ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Innate Immune Effector

scholarly journals The right microbial stimulus can direct innate immune effector cells to specific organ sites to clear pathology

2019 ◽  
Author(s):  
Shirin Kalyan ◽  
Mark Bazett ◽  
Ho Pan Sham ◽  
Momir Bosiljcic ◽  
Beryl Luk ◽  
...  
Keyword(s):  
Immune System ◽  
Innate Immune ◽  
Immune Memory ◽  
Immune Effector ◽  
Effector Cells ◽  
Adaptive Immune ◽  
Immune Effector Cells ◽  
Innate Immune Effector ◽  
Organ Site ◽  
Tissue Site

ABSTRACTRecent developments in understanding how the functional phenotype of the innate immune system is programmed has led to paradigm-shifting views on immunomodulation. These advances have overturned two long-held dogmas: only adaptive immunity confers immunological memory and innate immunity lacks specificity. This work describes the novel observation that innate immune effector cells can be recruited to specific tissues of the body where pathology is present by using a microbial-based immune stimulus that consists of an inactivated pathogen that typically resides or causes infection in that target tissue site. We demonstrate this principle using experimental models of cancer and infection for which different subcutaneously delivered microbial-based treatments were shown to induce the recruitment of immune effector cells to specific diseased organs. Amelioration of disease in a given organ niche was dependent on matching the correct microbial stimulus for the affected organ site but was independent of the nature of the pathology. This observation intriguingly suggests that the immune system, upon pathogen recognition, tends to direct its resources to the compartment in which the pathogen has previously been encountered and would be the most likely source of infection. Importantly, this phenomenon provides a novel means to therapeutically target innate immune effector cells to sites of specific disease localization to potentially treat a wide spectrum of pathologies, including cancer, infection, and chronic inflammatory disorders.AUTHOR SUMMARYVaccines that target adaptive immune memory have revolutionized medicine. This study describes a novel strategy that works as a modified innate immune “vaccine” that exploits the trained response of innate immune effector cells to clear pathology in a specific tissue site. Unlike memory of the adaptive immune system, which functions like a lock and key, innate immune memory is more akin to a reflex response – like experienced muscle or neural cells that are changed by a stimulus to respond more efficiently upon re-exposure. This change in behavior through experience is the definition of learning. Our study suggests that this innate immune learning occurs at different levels. Emergency hematopoiesis trains new innate immune cells in the bone marrow to respond quickly and effectively to a non-specific threat; whereas, pathogen-specific training occurs at sites where cells making up the immunologic niche have had interactions with a particular pathogen and have been trained to respond more robustly to it upon re-presentation in the context of a danger signal. The speed with which new immune cells are trained in the bone marrow in response to an imminent microbial threat and their subsequent recruitment to the target organ site where that microbe typically resides suggests there are ways the immune system communicates to coordinate this rapid response that are yet to be fully delineated. These findings provide a novel highly proficient way to harness the potent effector functions of the innate immune system to address a wide range of immune-based diseases.

Proteome characterization of sea star coelomocytes - The innate immune effector cells of echinoderms

PROTEOMICS ◽  
2011 ◽  
Vol 11 (17) ◽  
pp. 3587-3592 ◽  
Author(s):  
Catarina F. Franco ◽  
Romana Santos ◽  
Ana V. Coelho
Keyword(s):  
Innate Immune ◽  
Sea Star ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Innate Immune Effector

Autoimmunity mediated by innate immune effector cells

2001 ◽  
Vol 22 (6) ◽  
pp. 300-301 ◽  
Author(s):  
Jacques Zimmer ◽  
Huguette Bausinger ◽  
Henri de la Salle
Keyword(s):  
Innate Immune ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Innate Immune Effector

scholarly journals T Cell Memory to Vaccination

Vaccines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 84 ◽  
Author(s):  
Stephen M Todryk
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cytotoxic T Lymphocytes ◽  
Innate Immune ◽  
T Cell Memory ◽  
Immune Effector ◽  
Effector Cells ◽  
Vaccination Strategies ◽  
Immune Effector Cells ◽  
Innate Immune Effector

Most immune responses associated with vaccination are controlled by specific T cells of a CD4+ helper phenotype which mediate the generation of effector antibodies, cytotoxic T lymphocytes (CTLs), or the activation of innate immune effector cells. A rapidly growing understanding of the generation, maintenance, activity, and measurement of such T cells is leading to vaccination strategies with greater efficacy and potentially greater microbial coverage.

scholarly journals Fluorescent nanodiamonds engage innate immune effector cells: A potential vehicle for targeted anti-tumor immunotherapy

2017 ◽  
Vol 13 (3) ◽  
pp. 909-920 ◽  
Author(s):  
Lorena P. Suarez-Kelly ◽  
Amanda R. Campbell ◽  
Isaac V. Rampersaud ◽  
Ambika Bumb ◽  
Min S. Wang ◽  
...  
Keyword(s):  
Tumor Immunotherapy ◽  
Innate Immune ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Innate Immune Effector ◽  
Fluorescent Nanodiamonds

Autoimmunity mediated by innate immune effector cells

2001 ◽  
Vol 22 (6) ◽  
pp. 301
Author(s):  
Fu-Dong Shi ◽  
Nora Sarvetnick ◽  
Hans-Gustaf Ljunggren
Keyword(s):  
Innate Immune ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Innate Immune Effector

scholarly journals Secreted Semaphorin 5A Activates Immune Effector Cells and Is a Biomarker for Rheumatoid Arthritis

2014 ◽  
Vol 66 (6) ◽  
pp. 1461-1471 ◽  
Author(s):  
Christiane Gras ◽  
Britta Eiz-Vesper ◽  
Yarua Jaimes ◽  
Stephan Immenschuh ◽  
Roland Jacobs ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Semaphorin 5A
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