scholarly journals A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects

2007 ◽  
Vol 9 (5) ◽  
pp. 109 ◽  
Author(s):  
Rocky S Tuan
Keyword(s):  
Articular Cartilage ◽  
Autologous Chondrocyte Implantation ◽  
Second Generation ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Articular Cartilage Defects ◽  
Autologous Chondrocyte

scholarly journals Long-Term Clinical and MRI Results of Matrix-Assisted Autologous Chondrocyte Implantation for Articular Cartilage Defects of the Knee

Cartilage ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Peter Cornelius Kreuz ◽  
Richard Horst Kalkreuth ◽  
Philipp Niemeyer ◽  
Markus Uhl ◽  
Christoph Erggelet
Keyword(s):  
Articular Cartilage ◽  
Autologous Chondrocyte Implantation ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Articular Cartilage Defects ◽  
Autologous Chondrocyte

scholarly journals Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy

2019 ◽  
Vol 6 (1) ◽  
pp. 22 ◽  
Author(s):  
Rebecca Davies ◽  
Nicola Kuiper
Keyword(s):  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Autologous Chondrocyte Implantation ◽  
Weight Bearing ◽  
Cartilage Defects ◽  
Chondrocyte Implantation ◽  
Established Cell ◽  
Open Joint ◽  
Articular Cartilage Defects ◽  
Autologous Chondrocyte

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a highly organized extracellular matrix comprising collagen II fibrils, proteoglycans, glycosaminoglycans, and non-collagenous proteins. Damaged articular cartilage has a limited potential for healing and untreated defects often progress to osteoarthritis. High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing progress to late osteoarthritis. One such strategy, autologous chondrocyte implantation (ACI), was first reported in 1994 as a treatment for deep focal articular cartilage defects. ACI has since evolved to become a worldwide well-established surgical technique. For ACI, chondrocytes are harvested from the lesser weight bearing edge of the joint by arthroscopy, their numbers expanded in monolayer culture for at least four weeks, and then re-implanted in the damaged region under a natural or synthetic membrane via an open joint procedure. We consider the evolution of ACI to become an established cell therapy, its current limitations, and on-going strategies to improve its efficacy. The most promising developments involving cells and natural or synthetic biomaterials will be highlighted.

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