scholarly journals Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

2013 ◽  
Vol 5 (3) ◽  
pp. 28 ◽  
Author(s):  
Scott J Webster ◽  
Adam D Bachstetter ◽  
Linda J Van Eldik
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Behavioral Characterization

scholarly journals Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease

2011 ◽  
Vol 27 (4) ◽  
pp. 221-232 ◽  
Author(s):  
Huaqi Xiong ◽  
Debbie Callaghan ◽  
Jolanta Wodzinska ◽  
Jiejing Xu ◽  
Maryna Premyslova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Double Transgenic Mouse ◽  
Behavioral Characterization

Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 16 (5) ◽  
pp. 388-395 ◽  
Author(s):  
Hector Rosas-Hernandez ◽  
Elvis Cuevas ◽  
James B. Raymick ◽  
Bonnie L. Robinson ◽  
Syed F. Ali ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Amyloid Angiopathy ◽  
Western Blots ◽  
Model Of Alzheimer’S Disease ◽  
Serum Exosomes

Background: Alzheimer’s Disease (AD) is the most common type of dementia characterized by amyloid plaques containing Amyloid Beta (Aβ) peptides and neurofibrillary tangles containing tau protein. In addition to neuronal loss, Cerebral Amyloid Angiopathy (CAA) commonly occurs in AD. CAA is characterized by Aβ deposition in brain microvessels. Recent studies have suggested that exosomes (cell-derived vesicles containing a diverse cargo) may be involved in the pathogenesis of AD. Objective: Isolate and characterize brain-derived exosomes from a transgenic mouse model of AD that presents CAA. Methods: Exosomes were isolated from serum obtained from 13-month-old wild type and AD transgenic female mice using an exosome precipitation solution. Characterization of exosomal proteins was performed by western blots and dot blots. Results: Serum exosomes were increased in transgenic mice compared to wild types as determined by increased levels of the exosome markers flotillin and alix. High levels of neuronal markers were found in exosomes, without any difference any between the 2 groups. Markers for endothelial-derived exosomes were decreased in the transgenic model, while astrocytic-derived exosomes were increased. Exosome characterization showed increased levels of oligomeric Aβ and oligomeric and monomeric forms tau on the transgenic animals. Levels of amyloid precursor protein were also increased. In addition, pathological and phosphorylated forms of tau were detected, but no difference was observed between the groups. Conclusion: These data suggest that monomeric and oligomeric forms of Aβ and tau are secreted into serum via brain exosomes, most likely derived from astrocytes in the transgenic mouse model of AD with CAA. Studies on the implication of this event in the propagation of AD are underway.

Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background

2013 ◽  
Vol 557 ◽  
pp. 84-89 ◽  
Author(s):  
Kenghoe Lok ◽  
Hong Zhao ◽  
Hanlin Shen ◽  
Zejian Wang ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease

scholarly journals Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126317 ◽  
Author(s):  
Peng Liu ◽  
Jennifer B. Paulson ◽  
Colleen L. Forster ◽  
Samantha L. Shapiro ◽  
Karen H. Ashe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Pathology ◽  
Model Of Alzheimer’S Disease ◽  
Β Amyloid ◽  
Amyloid Oligomer

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

2010 ◽  
Vol 1348 ◽  
pp. 149-155 ◽  
Author(s):  
Roxanne Sterniczuk ◽  
Michael C. Antle ◽  
Frank M. LaFerla ◽  
Richard H. Dyck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Changes ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model
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