Effect of corrected GLI reference equations on carbon monoxide transfer factor interpretation

2021 ◽  
pp. 2004459
Author(s):  
Warren R. Ruehland ◽  
Celia J. Lanteri ◽  
Pam Matsas ◽  
Danny J. Brazzale
Keyword(s):  
Carbon Monoxide ◽  
Transfer Factor ◽  
Reference Equations

Global lung function initiative: Reference equations for the transfer factor for carbon monoxide (TLCO)

2016 ◽  
Author(s):  
Sanja Stanojevic ◽  
Brian Grham ◽  
Brendan Cooper ◽  
Bruce Thompson ◽  
Kim Carter ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Transfer Factor ◽  
Reference Equations

scholarly journals Effects of adopting the Global Lung Function Initiative 2017 reference equations on the interpretation of carbon monoxide transfer factor

2020 ◽  
Vol 55 (5) ◽  
pp. 1901905
Author(s):  
Danny J. Brazzale ◽  
Leigh M. Seccombe ◽  
Liam Welsh ◽  
Celia J. Lanteri ◽  
Claude S. Farah ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Transfer Factor ◽  
Teaching Hospitals ◽  
Younger Adults ◽  
Adult Females ◽  
Reference Set ◽  
Reference Equations ◽  
Lower Limit Of Normal ◽  
A Current

The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (TLCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of TLCO results.33 863 TLCO results (48% female, 88% Caucasian, n=930 aged <18 years) from clinical pulmonary function laboratories within three Australian teaching hospitals were analysed. The lower limit of normal (LLN) and proportion of patients with a TLCO below this value were calculated using GLI and other commonly used reference equations.The average TLCO LLN for GLI was similar or lower than the other equations, with the largest difference seen for Crapo equations (median: −1.25, IQR: −1.64, −0.86 mmol·min−1·kPa−1). These differences resulted in altered rates of reduced TLCO for GLI particularly for adults (+1.9% versus Miller to −27.6% versus Crapo), more so than for children (−0.8% versus Kim to −14.2% versus Cotes). For adults, the highest raw agreement for GLI was with Miller equations (94.7%), while for children it was with Kim equations (98.1%). Results were reclassified from abnormal to normal more frequently for younger adults, and for adult females, particularly when moving from Roca to GLI equations (30% of females versus 16% of males).The adoption of GLI TLCO reference equations in adults will result in altered interpretation depending on the equations previously used and to a greater extent in adult females. The effect on interpretation in children is less significant.

scholarly journals The impact of changing to the Global Lung Function Initiative reference equations for transfer factor in paediatrics

2020 ◽  
pp. 00412-2020
Author(s):  
Paul D. Burns ◽  
James Y. Paton
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Paediatric Patient ◽  
Transfer Factor ◽  
Reference Equations ◽  
The Difference ◽  
Predicted Values ◽  
Age Range ◽  
The Impact ◽  
Interpretation Of Results

The Global Lung Function Initiative (GLI) all age reference equations for carbon monoxide transfer factor were published in 2017 and endorsed by the ERS/ATS. In order to understand the impact of these new reference equations on the interpretation of results in children referred from haematology and oncology paediatric services, we retrospectively analysed transfer factor results from any paediatric patient referred from haematology oncology in the period 2010–2018. We examined TLCO, KCO and VA from 241 children (age range; 7–18, 130 male). The predicted values from Rosenthal and GLI were plotted against height. The difference in interpretation of results was analysed by looking at the percentage of patients <LLN for each parameter. Overall, the Rosenthal predicted values for TLCO were higher than GLI. Predicted KCO using Rosenthal was higher in all observations. In contrast, the Rosenthal predicted VA was generally lower than the GLI value. The GLI predicted values for transfer factor show considerable differences compared with currently used paediatric UK reference values, differences that will have a significant impact on interpretation of results.

Effect of HIV-1 and cytomegalovirus in bronchoalveolar lavage cells on the transfer factor for lung carbon monoxide in AIDS patients

AIDS ◽  
1991 ◽  
Vol 5 (11) ◽  
pp. 1333-1338 ◽  
Author(s):  
John R. Clarke ◽  
Judith Fleming ◽  
Katrina Donegan ◽  
Fiona M. Moss ◽  
Richard Nieman ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Bronchoalveolar Lavage ◽  
Transfer Factor ◽  
Aids Patients ◽  
Hiv 1

Transfer factor of the lung for carbon monoxide (TLCO) in morbid obese subjects

2015 ◽  
Author(s):  
Ebymar Arismendi ◽  
José Ríos ◽  
Josep Roca ◽  
Felip Burgos ◽  
Eva Rivas ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Transfer Factor ◽  
Obese Subjects ◽  
Morbid Obese
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