Concurrent Use of Bedaquiline and Delamanid for the Treatment of Fluoroquinolone-resistant Multidrug-resistant Tuberculosis: A Nationwide Cohort Study in South Korea

2020 ◽  
pp. 2003026 ◽  
Author(s):  
Yong-Soo Kwon ◽  
Doosoo Jeon ◽  
Hyungseok Kang ◽  
Jae-Joon Yim ◽  
Tae Sun Shim
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Concurrent Use

Cost of treatment for multidrug-resistant tuberculosis in South Korea

Respirology ◽  
2006 ◽  
Vol 11 (6) ◽  
pp. 793-798 ◽  
Author(s):  
Young Ae KANG ◽  
Yong-Jun CHOI ◽  
Young-Jae CHO ◽  
Sang Min LEE ◽  
Chul-Gyu YOO ◽  
...  
Keyword(s):  
South Korea ◽  
Multidrug Resistant ◽  
Cost Of Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Secondary erythrocytosis following drugs used in rifampicin/multidrug-resistant tuberculosis: a retrospective cohort study

2021 ◽  
Vol 8 (1) ◽  
pp. e001064
Author(s):  
Sirak Tesfamariam ◽  
Amon Solomon Ghebrenegus ◽  
Henok Woldu ◽  
Ephrem Fisseha ◽  
Gebremeskel Belai ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Statistical Significance ◽  
Multidrug Resistant ◽  
Hospital Data ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Time To Onset

BackgroundMultidrug-resistant tuberculosis (MDR-TB) drugs have never been associated with erythrocytosis. In Eritrea, however, several cases of incident erythrocytosis had been observed in the MDR-TB hospital. This study was aimed at exploring the association between MDR-TB drugs and secondary erythrocytosis, characterising the cases, and identifying other possible risk factors.MethodsA retrospective cohort study was conducted in Merhano National Referral MDR-TB hospital. Data were extracted from physically available clinical cards and laboratory results collected longitudinally between 23 June 2011 and 17 January 2021. Initially, univariate descriptive statistics (frequency, mean (SD), median (IQR) and range) were used as appropriate. Then, χ2 or Fisher χ2 test, and bivariate and/or multivariate Cox proportional hazard model were used to identify the predictors of incident erythrocytosis. All statistical analyses were conducted using R, and a two-sided alpha 0.05 was used to determine the statistical significance.ResultsA total of 257 patients’ medical cards were screened, and 219 were eligible for further analysis. The median age of the patients was 38 years (range: 13–90 years) and 54.8% were males. During the follow-up time, 31 (14.2%) patients developed secondary erythrocytosis yielding an incidence rate of 7.8 cases per 1000 person-months. On average, the median time to onset of the event was found to be 5-months (range: 1–24 months). Males were more likely to develop the event than females (adjusted HR=7.13, 95% CI=1.66 to 30.53), and as body weight increases by 1 kg, the likelihood of developing secondary erythrocytosis was found to increase by 7% (adjusted HR=1.07, 95% CI=1.03 to 1.10). Moreover, all cases of secondary erythrocytosis were found to be possibly associated with the MDR-TB drugs.ConclusionThe authors hypothesised that the incident erythrocytosis is possibly be associated with MDR-TB drugs, and further studies are required to substantiate this finding.

scholarly journals Predictors of Two Months Culture Conversion in Multidrug-Resistant Tuberculosis: Findings from a Retrospective Cohort Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93206 ◽  
Author(s):  
Anila Basit ◽  
Nafees Ahmad ◽  
Amer Hayat Khan ◽  
Arshad Javaid ◽  
Syed Azhar Syed Sulaiman ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Culture Conversion
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