scholarly journals Air pollution, lung function and COPD: results from the population-based UK Biobank study

2019 ◽  
Vol 54 (1) ◽  
pp. 1802140 ◽  
Author(s):  
Dany Doiron ◽  
Kees de Hoogh ◽  
Nicole Probst-Hensch ◽  
Isabel Fortier ◽  
Yutong Cai ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Smoking Status ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Chronic Obstructive ◽  
Lower Income ◽  
Uk Biobank ◽  
Cross Sectional ◽  
Lower Lung

Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors.We used UK Biobank data on 303 887 individuals aged 40–69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM2.5 and PM10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PMcoarse) and nitrogen dioxide (NO2) concentrations with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (FEV1/FVC <lower limit of normal). Effect modification was investigated for sex, age, obesity, smoking status, household income, asthma status and occupations previously linked to COPD.Higher exposures to each pollutant were significantly associated with lower lung function. A 5 µg·m−3 increase in PM2.5 concentration was associated with lower FEV1 (−83.13 mL, 95% CI −92.50– −73.75 mL) and FVC (−62.62 mL, 95% CI −73.91– −51.32 mL). COPD prevalence was associated with higher concentrations of PM2.5 (OR 1.52, 95% CI 1.42–1.62, per 5 µg·m−3), PM10 (OR 1.08, 95% CI 1.00–1.16, per 5 µg·m−3) and NO2 (OR 1.12, 95% CI 1.10–1.14, per 10 µg·m−3), but not with PMcoarse. Stronger lung function associations were seen for males, individuals from lower income households, and “at-risk” occupations, and higher COPD associations were seen for obese, lower income, and non-asthmatic participants.Ambient air pollution was associated with lower lung function and increased COPD prevalence in this large study.

scholarly journals Ambient air pollution, lung function and COPD: cross-sectional analysis from the WHO Study of AGEing and adult health wave 1

2020 ◽  
Vol 7 (1) ◽  
pp. e000684
Author(s):  
Mona Elbarbary ◽  
Artem Oganesyan ◽  
Trenton Honda ◽  
Patrick Kelly ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Adult Health ◽  
Cross Sectional ◽  
Lower Lung ◽  
Older Chinese ◽  
Sectional Analysis ◽  
Older Chinese Adults

BackgroundLong-term exposure to ambient air pollution leads to respiratory morbidity and mortality; however, the evidence of the effect on lung function and chronic obstructive pulmonary disease (COPD) in older adult populations is inconsistent.ObjectiveTo address this knowledge gap, we investigated the associations between particulate matter (PM), nitrogen dioxide (NO2) exposure and lung function, as well as COPD prevalence, in older Chinese adults.MethodsWe used data from the WHO Study on global AGEing and adult health (SAGE) China Wave 1, which includes 11, 693 participants from 64 townships in China. A cross-sectional analysis explored the association between satellite-based air pollution exposure estimates (PM with an aerodynamic diameter of ≤10 µm [PM10], ≤2.5 µm [PM2.5] and NO2) and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (defined as post-bronchodilator FEV1/FVC <70%). Data on lung function changes were further stratified by COPD status.ResultsHigher exposure to each pollutant was associated with lower lung function. An IQR (26.1 µg/m3) increase in PM2.5 was associated with lower FEV1 (−71.88 mL, 95% CI –92.13 to –51.64) and FEV1/FVC (−2.81, 95% CI −3.37 to –2.25). For NO2, an IQR increment of 26.8 µg/m3 was associated with decreases in FEV1 (−60.12 mL, 95% CI –84.00 to –36.23) and FVC (−32.33 mL, 95% CI –56.35 to –8.32). A 31.2 µg/m3 IQR increase in PM10 was linked to reduced FEV1 (−8.86 mL, 95% CI −5.40 to 23.11) and FEV1/FVC (−1.85, 95% CI −2.24 to –1.46). These associations were stronger for participants with COPD. Also, COPD prevalence was linked to higher levels of PM2.5 (POR 1.35, 95% CI 1.26 to 1.43), PM10 (POR 1.24, 95% CI 1.18 to 1.29) and NO2 (POR 1.04, 95% CI 0.98 to 1.11).ConclusionAmbient air pollution was associated with lower lung function, especially in individuals with COPD, and increased COPD prevalence in older Chinese adults.

Ambient air pollution exposure and lung function assessment of filling station attendants in Ibadan, Nigeria

2019 ◽  
Vol 34 (2) ◽  
pp. 211-218
Author(s):  
Toluwanimi Mobolade Oni ◽  
Godson R.E.E. Ana
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Air Pollutants ◽  
Ambient Air ◽  
Forced Expiratory Volume ◽  
Ambient Air Pollution ◽  
World Health ◽  
Health Administration ◽  
Cross Sectional ◽  
Filling Station

Abstract Background There is an increasing range of adverse health effects associated with air pollution at very low concentrations. Few studies have assessed respiratory parameters among filling station attendants. Objectives This study assessed air pollutants; particulate matter (PM10) and total volatile organic compounds (TVOC) concentrations at filling stations as well as determined forced expiratory volume in one second (FEV1) and peak expiratory flow rate (PEFR) levels among filling station attendants. Methods A cross-sectional study was conducted to assess PM10 and TVOC concentrations at 20 systematically selected filling stations in Ibadan North Local Government Area, Ibadan for 2 months using a Thermo Scientific pDR 1500 PM10 monitor and SF2000-TVOC meter. FEV1 and PEFR levels were measured in order to assess the effect of exposure to PM10 and TVOC on lung function of 100 filling station attendants using a PIKO-1 Electronic peakflow/FEV1 meter. Results Total mean PM10 concentrations (μg/m3) in the morning (43.7±16.5) and afternoon (27.8±7.9) were significantly lower (p<0.01) than the World Health Organization (WHO) guideline limit (50 μg/m3). Total mean TVOC concentrations (ppm) in the morning (12.0±3.4) and afternoon (5.6±2.4) were however significantly higher (p<0.01) than the Occupational Safety and Health Administration (OSHA) guideline limit (3 ppm). Mean FEV1 for filling station attendants was 1.63±0.39 and PEFR was 171.7±45.9. Conclusion Filling stations are hotspots for the emission of VOCs and PM10. However, filling station attendants in this study are at risk of exposure to high concentrations of VOCs but not PM10. FEV1 and PEFR values among filling station attendants were very low which could possibly be attributed to extended exposure to air pollutants. Regular medical examinations should also be conducted on filling station attendants in order to aid early detection of deviations in their health status.

scholarly journals Lung Function of Children at Three Sites of Varying Ambient Air Pollution Levels in Uganda: A Cross Sectional Comparative Study

2018 ◽  
Vol 15 (12) ◽  
pp. 2653 ◽  
Author(s):  
Bruce Kirenga ◽  
Rebecca Nantanda ◽  
Corina de Jong ◽  
Levicatus Mugenyi ◽  
Qingyu Meng ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Multiple Linear Regression Model ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Urban Residence ◽  
Biomass Smoke ◽  
Factors Associated ◽  
Pollution Levels ◽  
Lower Lung

Air pollution is a major cause of sub-optimal lung function and lung diseases in childhood and adulthood. In this study we compared the lung function (measured by spirometry) of 537 Ugandan children, mean age 11.1 years in sites with high (Kampala and Jinja) and low (Buwenge) ambient air pollution levels, based on the concentrations of particulate matter smaller than 2.5 micrometres in diameter (PM2.5). Factors associated with lung function were explored in a multiple linear regression model. PM2.5 level in Kampala, Jinja and Buwenge were 177.5 µg/m3, 96.3 µg/m3 and 31.4 µg/m3 respectively (p = 0.0000). Respectively mean forced vital capacity as % of predicted (FVC%), forced expiratory volume in one second as % of predicted (FEV1%) and forced expiratory flow 25–75% as % of predicted (FEF25–75%) of children in high ambient air pollution sites (Kampala and Jinja) vs. those in the low ambient air pollution site (Buwenge subcounty) were: FVC% (101.4%, vs. 104.0%, p = 0.043), FEV1% (93.9% vs. 98.0, p = 0.001) and FEF25–75% (87.8 vs. 94.0, p = 0.002). The proportions of children whose %predicted parameters were less than 80% predicted (abnormal) were higher among children living in high ambient air pollution than those living in lower low ambient air pollutions areas with the exception of FVC%; high vs. low: FEV1 < 80%, %predicted (12.0% vs. 5.3%, p = 0.021) and FEF25–75 < 80%, %predicted (37.7% vs. 29.3%, p = 0.052) Factors associated with lung function were (coefficient, p-value): FVC% urban residence (−3.87, p = 0.004), current cough (−2.65, p = 0.048), underweight (−6.62, p = 0.000), and overweight (11.15, p = 0.000); FEV1% underweight (−6.54, p = 0.000) and FEF25–75% urban residence (−8.67, p = 0.030) and exposure to biomass smoke (−7.48, p = 0.027). Children in study sites with high ambient air pollution had lower lung function than those in sites with low ambient air pollution. Urban residence, underweight, exposure to biomass smoke and cough were associated with lower lung function.

scholarly journals The Role of Socioeconomic Status in the Association of Lung Function and Air Pollution—A Pooled Analysis of Three Adult ESCAPE Cohorts

2019 ◽  
Vol 16 (11) ◽  
pp. 1901
Author(s):  
Dirk Keidel ◽  
Josep Maria Anto ◽  
Xavier Basagaña ◽  
Roberto Bono ◽  
Emilie Burte ◽  
...  
Keyword(s):  
Air Pollution ◽  
Socioeconomic Status ◽  
Lung Function ◽  
Linear Models ◽  
Ambient Air ◽  
Pooled Analysis ◽  
Ambient Air Pollution ◽  
Cross Sectional ◽  
Adverse Health Effects

Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or effect modifier of the association between ambient air pollution and lung function. Cross-sectional data from three European multicenter adult cohorts were pooled to assess factors associated with lung function, including annual means of home outdoor NO2. Pre-bronchodilator lung function was measured according to the ATS-criteria. Multiple mixed linear models with random intercepts for study areas were used. Three different factors (education, occupation and neighborhood unemployment rate) were considered to represent SES. NO2 exposure was negatively associated with lung function. Occupation and neighborhood unemployment rates were not associated with lung function. However, the inclusion of the SES-variable education improved the models and the air pollution-lung function associations got slightly stronger. NO2 associations with lung function were not substantially modified by SES-variables. In this multicenter European study we could show that SES plays a role as a confounder in the association of ambient NO2 exposure with lung function.

scholarly journals Effect of air pollution on lung function of road side hawkers

2020 ◽  
Vol 32 (4) ◽  
pp. 699-704
Author(s):  
Pawan Kumar ◽  
Sonisha Gupta ◽  
Smita Asthana
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Ambient Air ◽  
Cross Sectional Study ◽  
Ambient Air Pollution ◽  
Vulnerable Groups ◽  
Exposure Group ◽  
Cross Sectional ◽  
High Exposure ◽  
Low Exposure

Background: There is increasing concern of ambient air pollution as a global threat to humans. The most prominent effect of air pollution is on lung function. The air pollution causes decline in lung function amongst high exposure populations. There are some most vulnerable groups who are chronically exposed to ambient air pollution like traffic policemen, roadside hawkers, Banjara community in India, E-Rickshaw drivers etc. Methods: A cross sectional study was conducted in East Delhi, India. Spirometry was done for roadside hawkers having high exposure to ambient Air pollution and   working daily for 6-8 hours for the last more than 3 years. The low exposure group was taken from personnel working inside offices. The spirometry parameters of both the groups were compared. Student ‘T’ test was applied for statistical analysis with the help of SPSS software. Results: Comparison of FVC, FEV1 and FEV1/FVC ratio among two groups revealed lower values for the high exposure group which was statistically significant. Among high exposure group the mixed pattern of ventilation defect was observed. Among low exposure group normal pattern of lung function was observed. Conclusion: Roadside hawkers are a vulnerable group to ambient air pollution resulting in their lower values of lung function parameters with resultant mixed ventilator defect and consequently high risk for development of respiratory diseases in the future.

scholarly journals Ambient air pollution exposure and chronic bronchitis in the Lifelines cohort

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-216142
Author(s):  
Dany Doiron ◽  
Jean Bourbeau ◽  
Kees de Hoogh ◽  
Anna L Hansell
Keyword(s):  
Air Pollution ◽  
Chronic Bronchitis ◽  
Smoking Status ◽  
Fine Particulate Matter ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Air Pollution Exposure ◽  
Pollution Exposure

BackgroundFew large studies have assessed the relationship of long-term ambient air pollution exposure with the prevalence and incidence of symptoms of chronic bronchitis and cough.MethodsWe leveraged Lifelines cohort data on 132 595 (baseline) and 65 009 (second assessment) participants linked to ambient air pollution estimates. Logistic regression models adjusted for sex, age, educational attainment, body mass index, smoking status, pack-years smoking and environmental tobacco smoke at home were used to assess associations of air pollution with prevalence and incidence of chronic bronchitis (winter cough and sputum almost daily for ≥3 months/year), chronic cough (winter cough almost daily for ≥3 months/year) and prevalence of cough and sputum symptoms, irrespective of duration.ResultsAssociations were seen for all pollutants for prevalent cough or sputum symptoms. However, for prevalent and incident chronic bronchitis, statistically significant associations were seen for nitrogen dioxide (NO2) and black carbon (BC) but not for fine particulate matter (PM2.5). For prevalent chronic bronchitis, associations with NO2 showed OR: 1.05 (95% CI: 1.02 to 1.08) and with BC OR: 1.06 (95% CI: 1.03 to 1.09) expressed per IQR; corresponding results for incident chronic bronchitis were NO2 OR: 1.07 (95% CI: 1.02 to 1.13) and BC OR: 1.07 (95% CI: 1.02 to 1.13). In subgroup analyses, slightly stronger associations were observed among women, never smokers and younger individuals.ConclusionThis is the largest analysis to date to examine cross-sectional and longitudinal associations between ambient air pollution and chronic bronchitis. NO2 and BC air pollution was associated with increased odds of prevalent and incident chronic bronchitis.

scholarly journals Ambient air pollution is associated with airway inflammation in older women: a nested cross-sectional analysis

2020 ◽  
Vol 7 (1) ◽  
pp. e000549 ◽  
Author(s):  
Michael J Abramson ◽  
Claudia Wigmann ◽  
Hicran Altug ◽  
Tamara Schikowski
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Fine Particles ◽  
Geometric Mean ◽  
Ambient Air ◽  
Air Pollutant ◽  
Ambient Air Pollution ◽  
Chronic Obstructive ◽  
Pollution Effects ◽  
Respiratory Condition

BackgroundAir pollution is a risk factor for chronic obstructive pulmonary disease (COPD). Fraction of exhaled nitric oxide (FeNO) could be a useful biomarker for health effects of air pollutants. However, there were limited data from older populations with higher prevalence of COPD and other inflammatory conditions.MethodsWe obtained data from the German Study on the influence of Air pollution on Lung function, Inflammation and Ageing. Spirometry and FeNO were measured by standard techniques. Air pollutant exposures were estimated following the European Study of Cohorts for Air Pollution Effects protocols, and ozone (O3) measured at the closest ground level monitoring station. Multiple linear regression models were fitted to FeNO with each pollutant separately and adjusted for potential confounders.ResultsIn 236 women (mean age 74.6 years), geometric mean FeNO was 15.2ppb. Almost a third (n=71, 30.1%) of the women had some chronic inflammatory respiratory condition. A higher FeNO concentration was associated with exposures to fine particles (PM2.5), PM2.5absorbance and respirable particles (PM10). There were no significant associations with PMcoarse, NO2, NOx, O3 or length of major roads within a 1 km buffer. Restricting the analysis to participants with a chronic inflammatory respiratory condition, with or without impaired lung function produced similar findings. Adjusting for diabetes did not materially alter the findings. There were no significant interactions between individual pollutants and asthma or current smoking.ConclusionsThis study adds to the evidence to reduce ambient PM2.5 concentrations as low as possible to protect the health of the general population.

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