scholarly journals Serum sCD163 as a biomarker of adipose tissue inflammation in obstructive sleep apnoea patients: limits and perspectives

2017 ◽  
Vol 50 (2) ◽  
pp. 1701038
Author(s):  
Denis Monneret ◽  
Jean-Philippe Bastard
Keyword(s):  
Adipose Tissue ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Obstructive Sleep

scholarly journals Adipose tissue as a key player in obstructive sleep apnoea

2019 ◽  
Vol 28 (152) ◽  
pp. 190006 ◽  
Author(s):  
Silke Ryan ◽  
Claire Arnaud ◽  
Susan F. Fitzpatrick ◽  
Jonathan Gaucher ◽  
Renaud Tamisier ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Experimental Models ◽  
Complex Interaction ◽  
Health Concern ◽  
Metabolic Dysfunction ◽  
Major Health ◽  
Multiple Organs ◽  
Obstructive Sleep

Obstructive sleep apnoea (OSA) is a major health concern worldwide and adversely affects multiple organs and systems. OSA is associated with obesity in >60% of cases and is independently linked with the development of numerous comorbidities including hypertension, arrhythmia, stroke, coronary heart disease and metabolic dysfunction. The complex interaction between these conditions has a significant impact on patient care and mortality. The pathophysiology of cardiometabolic complications in OSA is still incompletely understood; however, the particular form of intermittent hypoxia (IH) observed in OSA, with repetitive short cycles of desaturation and re-oxygenation, probably plays a pivotal role. There is fast growing evidence that IH mediates some of its detrimental effects through adipose tissue inflammation and dysfunction. This article aims to summarise the effects of IH on adipose tissue in experimental models in a comprehensive way. Data from well-designed controlled trials are also reported with the final goal of proposing new avenues for improving phenotyping and personalised care in OSA.

scholarly journals Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation

2017 ◽  
Vol 49 (4) ◽  
pp. 1601731 ◽  
Author(s):  
Aoife M. Murphy ◽  
Amandine Thomas ◽  
Sophie J. Crinion ◽  
Brian D. Kent ◽  
Murtaza M. Tambuwala ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Insulin Signalling ◽  
Sleep Apnoea ◽  
M1 Macrophage ◽  
Insulin Signalling Pathway ◽  
Obstructive Sleep ◽  
Inflammatory Phenotype

Obstructive sleep apnoea (OSA) is increasingly associated with insulin resistance. The underlying pathophysiology remains unclear but intermittent hypoxia (IH)-mediated inflammation and subsequent dysfunction of the adipose tissue has been hypothesised to play a key role.We tested this hypothesis employing a comprehensive translational approach using a murine IH model of lean and diet-induced obese mice, an innovative IH system for cell cultures and a tightly controlled patient cohort.IH led to the development of insulin resistance in mice, corrected for the degree of obesity, and reduced insulin-mediated glucose uptake in 3T3-L1 adipocytes, associated with inhibition of the insulin-signalling pathway and downregulation of insulin-receptor substrate-1 mRNA. Providing mechanistic insight, IH induced a pro-inflammatory phenotype of visceral adipose tissue in mice with pro-inflammatory M1 macrophage polarisation correlating with the severity of insulin resistance. Complimentaryin vitroanalysis demonstrated that IH led to M1 polarisation of THP1-derived macrophages. In subjects without comorbidities (n=186), OSA was independently associated with insulin resistance. Furthermore, we found an independent correlation of OSA severity with the M1 macrophage inflammatory marker sCD163.This study provides evidence that IH induces a pro-inflammatory phenotype of the adipose tissue, which may be a crucial link between OSA and the development of insulin resistance.

scholarly journals Adipose tissue in obesity and obstructive sleep apnoea

2011 ◽  
Vol 39 (3) ◽  
pp. 746-767 ◽  
Author(s):  
M. R. Bonsignore ◽  
W. T. McNicholas ◽  
J. M. Montserrat ◽  
J. Eckel
Keyword(s):  
Adipose Tissue ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

2020 ◽  
Vol 134 (12) ◽  
pp. 1403-1432 ◽  
Author(s):  
Manal Muin Fardoun ◽  
Dina Maaliki ◽  
Nabil Halabi ◽  
Rabah Iratni ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Therapeutic Agents ◽  
Adipose Tissue Inflammation ◽  
Cellular Mechanisms ◽  
Tissue Inflammation ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Pro Inflammatory Cytokines

Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.

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