scholarly journals A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework

2016 ◽  
Vol 49 (1) ◽  
pp. 1600419 ◽  
Author(s):  
George D. Thurston ◽  
Howard Kipen ◽  
Isabella Annesi-Maesano ◽  
John Balmes ◽  
Robert D. Brook ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Air Pollution ◽  
Human Health ◽  
Health Effects ◽  
Health Effect ◽  
Analytical Framework ◽  
Policy Statement ◽  
Organ Systems ◽  
Central Nervous Systems ◽  
New Biomarkers

The American Thoracic Society has previously published statements on what constitutes an adverse effect on health of air pollution in 1985 and 2000. We set out to update and broaden these past statements that focused primarily on effects on the respiratory system. Since then, many studies have documented effects of air pollution on other organ systems, such as on the cardiovascular and central nervous systems. In addition, many new biomarkers of effects have been developed and applied in air pollution studies.This current report seeks to integrate the latest science into a general framework for interpreting the adversity of the human health effects of air pollution. Rather than trying to provide a catalogue of what is and what is not an adverse effect of air pollution, we propose a set of considerations that can be applied in forming judgments of the adversity of not only currently documented, but also emerging and future effects of air pollution on human health. These considerations are illustrated by the inclusion of examples for different types of health effects of air pollution.

scholarly journals Aerosol exposure versus aerosol cooling of climate: what is the optimal emission reduction strategy for human health?

2010 ◽  
Vol 10 (19) ◽  
pp. 9441-9449 ◽  
Author(s):  
J. Löndahl ◽  
E. Swietlicki ◽  
E. Lindgren ◽  
S. Loft
Keyword(s):  
Climate Change ◽  
Air Pollution ◽  
Human Health ◽  
Health Effects ◽  
Health Effect ◽  
Health Benefit ◽  
Cooling Effect ◽  
Short Time Scale ◽  
Ship Emissions ◽  
Aerosol Emissions

Abstract. Particles, climate change, and health have thought-provoking interactions. Air pollution is one of the largest environmental problems concerning human health. On the other hand, aerosol particles can have a cooling effect on climate and a reduction of those emissions may result in an increased temperature globally, which in turn may have negative health effects. The objective of this work was to investigate the "total health effects" of aerosol emissions, which include both exposure to particles and consequences for climate change initiated by particles. As a case study the "total health effect" from ship emissions was derived by subtracting the number of deaths caused by exposure with the estimated number of lives saved from the cooling effect of the emissions. The analysis showed that, with current level of scientific understanding, it could not be determined whether ship emissions are negative or positive for human health on a short time scale. This first attempt to approximate the combined effect of particle emissions on health shows that reductions of particulate air pollution will in some cases (black carbon) have win-win effects on health and climate, but sometimes also cause a shift from particle exposure-related health effects towards an increasing risk of health consequences from climate change. Thus, measures to reduce aerosol emissions have to be coupled with climate change mitigation actions to achieve a full health benefit on a global level.

scholarly journals Health Effects Associated With Electronic Cigarette Use: Automated Mining of Online Forums (Preprint)

2019 ◽  
Author(s):  
My Hua ◽  
Shouq Sadah ◽  
Vagelis Hristidis ◽  
Prue Talbot
Keyword(s):  
Health Effects ◽  
Electronic Cigarettes ◽  
Health Effect ◽  
Online Information ◽  
Online Forums ◽  
Unified Medical Language System ◽  
Organ Systems ◽  
Negative Sentiment ◽  
Specific Symptoms ◽  
Medical Concepts

BACKGROUND Our previous infodemiological study was performed by manually mining health-effect data associated with electronic cigarettes (ECs) from online forums. Manual mining is time consuming and limits the number of posts that can be retrieved. OBJECTIVE Our goal in this study was to automatically extract and analyze a large number (>41,000) of online forum posts related to the health effects associated with EC use between 2008 and 2015. METHODS Data were annotated with medical concepts from the Unified Medical Language System using a modified version of the MetaMap tool. Of over 1.4 million posts, 41,216 were used to analyze symptoms (undiagnosed conditions) and disorders (physician-diagnosed terminology) associated with EC use. For each post, sentiment (positive, negative, and neutral) was also assigned. RESULTS Symptom and disorder data were categorized into 12 organ systems or anatomical regions. Most posts on symptoms and disorders contained negative sentiment, and affected systems were similar across all years. Health effects were reported most often in the neurological, mouth and throat, and respiratory systems. The most frequently reported symptoms and disorders were headache (n=939), coughing (n=852), malaise (n=468), asthma (n=916), dehydration (n=803), and pharyngitis (n=565). In addition, users often reported linked symptoms (eg, coughing and headache). CONCLUSIONS Online forums are a valuable repository of data that can be used to identify positive and negative health effects associated with EC use. By automating extraction of online information, we obtained more data than in our prior study, identified new symptoms and disorders associated with EC use, determined which systems are most frequently adversely affected, identified specific symptoms and disorders most commonly reported, and tracked health effects over 7 years.

scholarly journals Human health effects of traffic-related air pollution (TRAP): a scoping review protocol

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Carlyn J. Matz ◽  
Marika Egyed ◽  
Robyn Hocking ◽  
Shayesta Seenundun ◽  
Nick Charman ◽  
...  
Keyword(s):  
Air Pollution ◽  
Human Health ◽  
Health Effects ◽  
Scoping Review ◽  
Review Protocol ◽  
Human Health Effects

scholarly journals Health effects of long-term exposure to air pollution: An overview of major respiratory and cardiovascular diseases and diabetes

2012 ◽  
Vol 18 (4-2) ◽  
pp. 617-622 ◽  
Author(s):  
Zorana Jovanovic-Andersen
Keyword(s):  
Air Pollution ◽  
Human Health ◽  
Health Effects ◽  
Convincing Evidence ◽  
Urban Setting ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Limit Values ◽  
Public Health Burden

Large number of studies provided convincing evidence for adverse effects of exposure to outdoor air pollution on human health, and served as basis for current USA and EU Air Quality Standards and limit values. Still, new knowledge is emerging, expanding our understanding of vast effects of exposure to air pollution on human health of this ubiquitous exposure affecting millions of people in urban setting. This paper focuses on the studies of health effects of long-term (chronic) exposures to air pollution, and includes major chronic and acute diseases in adults and especially elderly, which will present increasing public health burden, due to improving longevity and projected increasing numbers of elderly. The paper gives overview over the most relevant and latest literature presented by different health outcomes: chronic obstructive pulmonary disease, asthma, pneumonia, cardiovascular disease, and diabetes.

Health-relevant influences of air substances and meteorological conditions

2020 ◽  
Author(s):  
Stephanie Koller ◽  
Christa Meisinger ◽  
Markus Wehler ◽  
Elke Hertig
Keyword(s):  
Climate Change ◽  
Emergency Department ◽  
Air Pollution ◽  
Particulate Matter ◽  
Human Health ◽  
Health Effects ◽  
Supplementary Information ◽  
Human Organism ◽  
Average Risk ◽  
Emergency Department Data

<p>For a long time it has been known that exceptionally strong and long-lasting heat waves have negative health effects on the population, which is expressed in an intensification of existing diseases and over-mortality of certain risk groups (Kampa, Castanas 2008). Often associated with heat are stagnant airflow conditions that cause a large increase in the concentration of certain air substances (Ebi, McGregor 2008). Many of these air substances have a strong adverse effect on the human organism (Kampa, Castanas 2008).</p><p>The aim of the project is to investigate the actual hazard potential of health-relevant air pollution- and climatological variables by quantifying the effects on human health of increased exposure to air constituents and temperature extremes. Different multivariate statistical methods such as correlation analysis, regression models and random forests, extreme value analysis and individual case studies are used.</p><p>As a medical data basis for this purpose, the emergency department data of the University Hospital Augsburg are regarded. In addition to the diagnosis, supplementary information such as age, gender, place of residence and pre-existing conditions of the patients are used. Among the air constituents, the focus is on ozone, nitrogen dioxide and particulate matter. In the meteorological part, the focus is primarily on temperature, which is not only a direct burden but, as in the case of ozone, also has a decisive influence on the formation of ozone molecules. However, a large number of other meteorological parameters such as precipitation, relative humidity and wind speed as well as the synoptic situation also play a major role in the formation, decomposition process and the distribution of pollutants (Ebi, McGregor 2008).</p><p>The first major question to answer is whether air-pollution and meteorological stress situations are visible in the emergency department data. Further in-depth questions are which factors have the greatest negative impact, what is the most common environment-related disease, which weather conditions carry a higher than average risk and what are the health risks of climate change.</p><p>Ideally, the analysis may also provide a short-term forecast from which to derive whether or not there will be an above or below average number of visits to the emergency department.</p><p>The project is funded by the German Federal Foundation for Environment (DBU) and the German Research Foundation (DFG) - project number 408057478.</p><p>Literature</p><p>Ebi K., McGregor G. (2008): Climate Change, Tropospheric Ozone and Particulate Matter, and Health Impacts. doi: 10.1289/ehp.11463</p><p>Kampa M., Castanas E. (2008): Human health effects of air pollution. In: Environmental Pollution 151(2): 362-367. doi: 10.1016/j.envpol.2007.06.012</p>

scholarly journals TUBE Project: Transport-Derived Ultrafines and the Brain Effects

2021 ◽  
Vol 19 (1) ◽  
pp. 311
Author(s):  
Maria-Viola Martikainen ◽  
Päivi Aakko-Saksa ◽  
Lenie van den Broek ◽  
Flemming R. Cassee ◽  
Roxana O. Carare ◽  
...  
Keyword(s):  
Air Pollution ◽  
Health Effects ◽  
Air Pollutants ◽  
Experimental Studies ◽  
Air Pollutant ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
Organ Systems ◽  
The Brain

The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.

scholarly journals Reactive nitrogen compounds and their influence on human health: an overview

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Rolf Nieder ◽  
Dinesh K. Benbi
Keyword(s):  
Air Pollution ◽  
Human Health ◽  
Health Effects ◽  
Crop Yields ◽  
Stratospheric Ozone ◽  
Critical Role ◽  
Ultra Violet ◽  
Reactive Nitrogen ◽  
Wide Range ◽  
Human Health Effects

Abstract Nitrogen (N) is a critical component of food security, economy and planetary health. Human production of reactive nitrogen (Nr) via Haber-Bosch process and cultivation-induced biological N2 fixation (BNF) has doubled global N cycling over the last century. The most important beneficial effect of Nr is augmenting global food supplies due to increased crop yields. However, increased circulation of Nr in the environment is responsible for serious human health effects such as methemoglobinemia (“blue baby syndrome”) and eutrophication of coastal and inland waters. Furthermore, ammonia (NH3) emission mainly from farming and animal husbandary impacts not only human health causing chronic lung disease, inflammation of human airways and irritation of eyes, sinuses and skin but is also involved in the formation of secondary particulate matter (PM) that plays a critical role in environment and human health. Nr also affects human health via global warming, depletion of stratospheric ozone layer resulting in greater intensity of ultra violet B rays (UVB) on the Earth’s surface, and creation of ground-level ozone (through reaction of NO2 with O2). The consequential indirect human health effects of Nr include the spread of vector-borne pathogens, increased incidence of skin cancer, development of cataracts, and serious respiratory diseases, besides land degradation. Evidently, the strategies to reduce Nr and mitigate adverse environmental and human health impacts include plugging pathways of nitrogen transport and loss through runoff, leaching and emissions of NH3, nitrogen oxides (NO x ), and other N compounds; improving fertilizer N use efficiency; reducing regional disparity in access to N fertilizers; enhancing BNF to decrease dependence on chemical fertilizers; replacing animal-based proteins with plant-based proteins; adopting improved methods of livestock raising and manure management; reducing air pollution and secondary PM formation; and subjecting industrial and vehicular NO x emission to pollution control laws. Strategic implementation of all these presents a major challenge across the fields of agriculture, ecology and public health. Recent observations on the reduction of air pollution in the COVID-19 lockdown period in several world regions provide an insight into the achievability of long-term air quality improvement. In this review, we focus on complex relationships between Nr and human health, highlighting a wide range of beneficial and detrimental effects.

Nutraceuticals with anti-inflammatory and anti-oxidant properties as intervention for reducing the health effects of fine particulate matter: Potential and Prospects

2021 ◽  
Vol 24 ◽  
Author(s):  
Tanwi Trushna ◽  
Amit K. Tripathi ◽  
Sindhuprava Rana ◽  
Rajnarayan R. Tiwari
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Human Health ◽  
Health Effects ◽  
In Vivo Studies ◽  
Future Research ◽  
Individual Level ◽  
Anti Inflammatory

: Air pollution, especially particulate matter pollution adversely affects human health. A growing pool of evidence has emerged which underscores the potential of individual-level nutritional interventions in attenuating the adverse health impact of exposure to PM2.5. Although controlling emission and reducing the overall levels of air pollution remains the ultimate objective globally, the sustainable achievement of such a target and thus consequent protection of human health will require a substantial amount of time and concerted efforts worldwide. In the meantime, smaller-scale individual-level interventions that can counter the inflammatory or oxidative stress effects triggered by exposure to particulate matter may be utilized to ameliorate the health effects of PM2.5 pollution. One such intervention is incorporation of nutraceuticals in the diet. Here, we present a review of the evidence generated from various in vitro, in vivo and human studies regarding the effects of different anti-inflammatory and antioxidant nutraceuticals in ameliorating the health effects of particulate matter air pollution. The studies discussed in this review suggest that these nutraceuticals when consumed as a part of the diet, or as additional supplementation, can potentially negate the cellular level adverse effects of exposure to particulate pollution. The potential benefits of adopting a non-pharmacological diet-based approach to air pollution-induced disease management have also been discussed. We argue that before a nutraceuticals-based approach can be used for widespread public adoption, further research, especially human clinical trials, is essential to confirm the beneficial action of relevant nutraceuticals and to explore the safe limits of human supplementation and the risk of side effects. Future research should focus on systematically translating bench-based knowledge regarding nutraceuticals gained from in-vitro and in-vivo studies into clinically usable nutritional guidelines.

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