scholarly journals Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997–2008

2016 ◽  
Vol 48 (5) ◽  
pp. 1453-1461 ◽  
Author(s):  
John P. Hutchinson ◽  
Tricia M. McKeever ◽  
Andrew W. Fogarty ◽  
Vidya Navaratnam ◽  
Richard B. Hubbard
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Biopsy ◽  
International Classification Of Diseases ◽  
Surgical Lung Biopsy ◽  
Using Data ◽  
Lung Biopsies ◽  
The Uk

International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease (ILD), which may lead to more surgical lung biopsies. This study aimed to assess the risk of this procedure in patients from the UK.We used Hospital Episodes Statistics data from 1997 to 2008 to assess the frequency of surgical lung biopsy for ILD in England, UK. We identified cardiothoracic surgical patients using International Classification of Diseases revision 10 codes for ILD and Office of Population Censuses and Surveys Classification of Interventions and Procedures version 4 codes for surgical lung biopsy. We excluded those with lung resections or lung cancer. We estimated in-hospital, 30-day and 90-day mortality following the procedure, and linked to cause of death using data from the UK Office of National Statistics.We identified 2820 patients with ILD undergoing surgical lung biopsy during the 12-year period. The number of biopsies increased over the time period studied. In-hospital, 30-day and 90-day mortality were 1.7%, 2.4% and 3.9%, respectively. Male sex, increasing age, increasing comorbidity and open surgery were risk factors for mortality.Surgical lung biopsy for ILD has a similar mortality to lobectomy for lung cancer, and clinicians and patients should understand the likely risks involved.

scholarly journals The role of surgical lung biopsy in the management of interstitial lung disease: experience from a single institution in the UK

2013 ◽  
Vol 17 (2) ◽  
pp. 253-257 ◽  
Author(s):  
Vivienne Blackhall ◽  
Mohammed Asif ◽  
Alessandra Renieri ◽  
Serenella Civitelli ◽  
Alan Kirk ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Single Institution ◽  
Surgical Lung Biopsy ◽  
Disease Experience ◽  
The Uk

scholarly journals Procedure volume and mortality after surgical lung biopsy in interstitial lung disease

2019 ◽  
Vol 53 (2) ◽  
pp. 1801164 ◽  
Author(s):  
Jolene H. Fisher ◽  
Shane Shapera ◽  
Teresa To ◽  
Theodore K. Marras ◽  
Andrea Gershon ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Operative Mortality ◽  
Patient Characteristics ◽  
Population Based ◽  
Study Objective ◽  
Surgical Lung Biopsy ◽  
Volume Outcome ◽  
Lung Biopsies

Surgical volume–outcome relationships are well established but have not been studied in patients with interstitial lung disease (ILD) undergoing surgical lung biopsy (SLB). Our study objective was to determine if hospital SLB volume is associated with post-operative mortality in patients with ILD.A cohort study using administrative, population-based data from Ontario, Canada was performed in adults with ILD who underwent a SLB between 2001 and 2014. The association between yearly hospital SLB volume and 30-day post-operative mortality was assessed using multilevel logistic regression modelling.3057 surgical lung biopsies for ILD were performed during the study period with a median (interquartile range) yearly hospital volume of 73 (34–143) procedures. 30-day mortality was 7.1%, 20.2% and 1.9% in overall, nonelective and elective patients, respectively. Higher yearly hospital SLB volume was associated with lower odds of 30-day post-operative mortality after adjusting for patient characteristics (OR 0.84, 95% CI 0.73–0.97; p=0.02), with the association appearing stronger for nonelective versus elective procedures (OR 0.84, 95% CI 0.69–1.02; p=0.08 versus OR 0.94, 95% CI 0.74–1.18; p=0.57).Higher yearly hospital SLB volume was associated with lower post-operative mortality in patients with ILD, with the association appearing to be mainly driven by nonelective cases. SLB mortality was significantly higher for nonelective cases.

scholarly journals Concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in patients with diffuse interstitial lung disease

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yoshiaki Zaizen ◽  
Yasuo Kohashi ◽  
Kishio Kuroda ◽  
Kazuhiro Tabata ◽  
Yuka Kitamura ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Usual Interstitial Pneumonia ◽  
Airway Disease ◽  
Surgical Lung Biopsy ◽  
High Concordance ◽  
Transbronchial Lung Cryobiopsy

Abstract Background Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for the diagnosis of interstitial lung disease (ILD). However, only one study has compared TBLC and surgical lung biopsy (SLB) performed on the same patients. Methods We identified seven patients with ILD with TBLC and SLB. We evaluated the clinical characteristics and made a pathological diagnosis based on the official ATS/ERS/JRS/ALAT clinical practice guideline of idiopathic pulmonary fibrosis with both TBLC and SLB. Results Six cases were diagnosed as Usual interstitial pneumonia (UIP) in both TBLC and SLB. One case was diagnosed as indeterminate for UIP with TBLC and probable UIP with SLB. Etiological diagnosis with TBLC and SLB were concordant in 2 cases of idiopathic pulmonary fibrosis (IPF) but discordant for other diagnoses. Major histological findings of UIP including dense fibrosis, peripheral distribution, and fibroblastic foci showed high concordance between TBLC and SLB, which implies that TBLC can reliably detect these features. In contrast, loose fibrosis, cellular infiltration, and airway disease showed poor concordance between the two methods. Conclusion Our study showed that TBLC is useful for UIP diagnosis but not for other ILD. With a multidisciplinary approach, diagnosis of IPF may be determined by TBLC, whereas ILD other than IPF may require SLB.

The clinical value of surgical lung biopsy in 166 patients with suspected interstitial lung disease

2015 ◽  
Author(s):  
Lisa Nicol ◽  
David McAllister ◽  
Catriona Graham ◽  
Pauline McFarlane ◽  
Gareth Stewart ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Clinical Value ◽  
Surgical Lung Biopsy

The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic algorithm of interstitial lung disease

2015 ◽  
Vol 10 (5) ◽  
pp. 589-595 ◽  
Author(s):  
Lars Hagmeyer ◽  
Dirk Theegarten ◽  
Jeremias Wohlschläger ◽  
Marcel Treml ◽  
Sandhya Matthes ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Diagnostic Algorithm ◽  
Surgical Lung Biopsy
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