Amoxicillin/Clavulanic Acid Versus Cefotaxime for Antimicrobial Prophylaxis in Abdominal Surgery: A Randomized Trial

2002 ◽  
Vol 14 (4) ◽  
pp. 366-372 ◽  
Author(s):  
F. Tonelli ◽  
T. Mazzei ◽  
A. Novelli ◽  
P. Mazzoni ◽  
F. Ficari ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Randomized Trial ◽  
Clavulanic Acid ◽  
Antimicrobial Prophylaxis ◽  
Acid Versus ◽  
Amoxicillin Clavulanic Acid

Amoxicillin-clavulanic acid versus cefotaxime in the therapy of bacterial infections in cirrhotic patients

2000 ◽  
Vol 32 (4) ◽  
pp. 596-602 ◽  
Author(s):  
Elena Ricart ◽  
Germán Soriano ◽  
Maria Teresa Novella ◽  
Jordi Ortiz ◽  
Míriam Sàbat ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Acid Versus ◽  
Amoxicillin Clavulanic Acid ◽  
Cirrhotic Patients

scholarly journals Performance Validation of Selective Screening Agars for Guiding Antimicrobial Prophylaxis in Patients Undergoing Prostate Biopsy

2018 ◽  
Vol 56 (9) ◽  
Author(s):  
Sofie C. M. Tops ◽  
Marlie Bruens ◽  
Sacha van Mook-Vermulst ◽  
Diane Lamers-Jansen ◽  
Tobias Engel ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Clavulanic Acid ◽  
Prostate Biopsy ◽  
Culture Media ◽  
Antimicrobial Prophylaxis ◽  
Growth Control ◽  
Added Value ◽  
Oral Antibiotic ◽  
Selective Media ◽  
Amoxicillin Clavulanic Acid

ABSTRACT A rectal culture-guided antimicrobial prophylaxis strategy may prevent infections after transrectal ultrasound-guided prostate biopsy (TRUSP). The use of selective culture media could assist the choice of appropriate antibiotic prophylaxis. The objective of our study was to evaluate the performance of four selective media used for guidance of oral antibiotic prophylaxis in TRUSP. In this prospective validation study, we used MacConkey media with vancomycin plus one of the following antibiotics: ciprofloxacin (McC3+CIP/V), trimethoprim (McC3+TMP/V), fosfomycin (McC3+FOF/V), and amdinocillin-amoxicillin-clavulanic acid (McC3+MEC/V). First, clinical strains of Gram-negative bacilli (GNB) (n = 33) were evaluated for growth on the selective media. Thereafter, rectal swabs (n = 97) were randomly collected from residual material of fresh stool samples and plated on a growth control and the four selective media. Levels of recovery of GNB on the growth control and selective media were compared, and the MICs of the antibiotics used in this study were determined. The sensitivity and specificity of the four selective media amounted, respectively, to 90.0% (55.5 to 99.8%) and 98.7% (93.1 to 100.0%) for McC3+CIP/V, 95.7% (85.2 to 99.5%) and 100.0% (91.6 to 100.0%) for McC3+TMP/V, 95.5% (84.5 to 99.4%) and 97.8% (88.2 to 99.9%) for McC3+FOF/V, and 100.0% (76.8 to 100.0%) and 97.6% (87.4 to 99.9%) for McC3+MEC/V. In conclusion, the four selective media were sufficiently sensitive and specific for the identification of rectal GNB resistant to ciprofloxacin, trimethoprim, fosfomycin, or amdinocillin-amoxicillin-clavulanic acid. These media can have added value in streamlining the optimal culture based antibiotic prophylaxis in TRUSP in a non-labor-intensive manner.

scholarly journals Efficacy of amoxicillin-clavulanic acid versus ceftriaxone in children hospitalized under 5 years of age with uncomplicated community acquired pneumonia.

2020 ◽  
Vol 27 (11) ◽  
pp. 2339-2344
Author(s):  
Huriya Abid ◽  
Wajiha Rizwan ◽  
Irfan Naeem ◽  
Aysha Mansoor Lodhi ◽  
Muhammad Nasir Rana
Keyword(s):  
Clavulanic Acid ◽  
Controlled Trial ◽  
Community Acquired Pneumonia ◽  
Duration Of Symptoms ◽  
Treatment Groups ◽  
Acid Versus ◽  
Group A ◽  
Amoxicillin Clavulanic Acid ◽  
Group B ◽  
Children Under 5

Objectives: Community acquired pneumonia (CAP) is considered to be the commonest reason for hospitalization among children. Pneumonia is the leading cause of mortality among children in Pakistan in children, causing 33% of all deaths in infants and 37% of all deaths in children 1 to 4 years. The aim of current study was to compare efficacy of amoxicillin-clavulanic acid versus ceftriaxone among children under 5 years of age, hospitalized having uncomplicated CAP. Study Design: Randomized Controlled trial (RCT). Setting: Department of Pediatric Medicine, The Children Hospital and Institute of Child Health, Lahore. Period: 01/01/2019 to 30/06/2019. Material & Methods: A total of 210 (105 in each group) children aged between 2 to 60 months, diagnosed having CAP were randomly allocated into either Group-A (received IV amoxicillin-clavulanic acid) or Group B (received IV ceftriaxone). Efficacy in terms of response of both treatment groups was noted after 5 days treatment. Results: Overall, mean age was noted as 14.68±15.7 months. Majority (n=131, 32.4%) were male and aged between 1 to 12 months (n=135, 64.3%). Mean duration of symptoms was noted as 3.60±1.69 days. Efficacy was significantly higher in children treated with ceftriaxone as compared to those treated with Amoxicillin/Clavulanic acid (96.2% vs. 76.2%; p<0.001). This difference was significant across all age, gender and duration of symptom groups (p<0.05). Conclusion: The efficacy was significantly higher in children treated with ceftriaxone as compared to Amoxicillin/Clavulanic acid.

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