Late Results of Activator-Treatment: A cephalometric study

1976 ◽  
Vol 3 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Johan Ahlgren ◽  
Cristina Laurin
Keyword(s):  
High Growth ◽  
Late Results ◽  
Class Iii ◽  
Lower Face ◽  
Decisive Importance ◽  
Long Term Effect ◽  
Significant Difference ◽  
Maxilla And Mandible ◽  
Cephalometric Study

The purpose of this study was to analyse cephalometrically the long-term effect of Activator treatment on the dentofacial skeleton in 50 consecutively treated cases of postnormal and prenormal occlusion. Comparisons of dentofacial form between successful and unsuccessful cases were performed. The results of the study showed that the sagittal relationship between the jaws became normal in postnormal and prenormal cases during Activator treatment. The effect was achieved mainly by reciprocal dentoalveolar changes of the maxilla and mandible supported by a retardation of the forward growth of the maxilla in Class II cases and a stimulation of the forward growth of the maxilla in Class III cases. The normal downward-forward growth of the mandible appeared unaffected. The effect of Activator treatment on the vertical growth of the jaws was a significant increase in lower face height (bite-raising). No tendency to induce a harmful posterior growth rotation of the mandible was noted. Before treatment there was no highly significant difference in the morphology of the dentofacial skeleton between successfully and unsuccessfully treated Activator cases, except for the basal relationship between the jaws (ss-n-sm) which was larger in the successful cases. It would rather appear that good cooperation, high growth intensity and a favourable growth pattern of the patient together with a well constructed appliance is of decisive importance for a successful result of treatment.

scholarly journals Dynamic Microbial Shifts and Signatures of Long-Term Remission in Allergic Rhinitis After an Herbal Formula Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Libing Zhu ◽  
Yuning Wu ◽  
Chenglong Lin ◽  
Lin Tang ◽  
Bin Yu ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Tca Cycle ◽  
Diversity Indices ◽  
Sustained Remission ◽  
Herbal Formula ◽  
Long Term Effect ◽  
Significant Difference ◽  
Ppar Signaling ◽  
Underlying Mechanisms

A mixed Chinese herbal formula, Xiao-Qing-Long-Decoction (XQLD), may contribute to sustained remission in allergic rhinitis (AR), but it is unknown which factors determine such long-term effect. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from AR patients at four different times were analyzed to compare the dynamic bacterial community and structure shifts. Diversity indices Chao1 showed significant difference across different time (p<0.05), and the Kruskal-Wallis test identified that Dialister (OTU_31), Roseburia (OTU_36), Bacteroides (OTU_22), Bacteroides (OTU_2040), and Prevotella_9 (OTU_5) were the significant differential bacterial taxa (p<0.05). These distinctive genera were significantly associated with the change of AR clinical indices and the predicted functional pathways such as PPAR signaling pathway, peroxisome, and citrate cycle (TCA cycle) (p<0.05), indicating that they may be important bacterial signatures involving in the sustained remission in AR (p<0.05). Besides, lower Firmicutes/Bacteroidetes (F/B) ratio at 6 months follow-up may also contribute to the long-term remission of AR. No seriously adverse events and safety concerns were observed in this study. In conclusion, XQLD is a meaningful, long-term efficient and safe medication for AR treatment. The underlying mechanisms of sustained remission in AR after XQLD treatment may be associated with the dynamic alteration of featured gut bacteria taxa.

scholarly journals Whether Chinese Medicine Have Effect on Halitosis: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xinyu Wu ◽  
Jie Zhang ◽  
Yikun Zhou ◽  
Ze He ◽  
Qiaoyi Cai ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Chinese Medicine ◽  
Subgroup Analysis ◽  
Social Life ◽  
Meta Analysis ◽  
Effective Rate ◽  
Long Term Effect ◽  
Study Selection ◽  
Significant Difference

Object. Halitosis has great adverse impact on personal and social life. There is no strong evidence for the effect of Chinese medicine (CM) and combined Chinese and western medicine (CWM) on halitosis. The aim of the present study is to evaluate the effective rate of CM and CWM on halitosis. Materials and Methods. Literature search in English and Chinese was conducted in PubMed, Embase, CNKI, CBM, and Wanfang database. Study selection and data collection were conducted. Risks of bias were assessed by the Cochrane tool. Synthesis of results was done by RevMan 5.3. p<0.05 was considered significant difference. Subgroup analysis by classification of halitosis and sensitivity analysis were also conducted. Results. Seventeen studies were included. The follow-up length ranged from five days to eight weeks. CM had significantly better effect than WM on intraoral halitosis (I2 =24%; RR=1.21 (95% CI, 1.04, 1.40), P=0.01) and extraoral halitosis (I2 =0; RR=1.39 (95% CI, 1.19, 1.63), P<0.0001). CWM had significantly better effect than WM on intraoral halitosis (I2 =0; RR=1.25 (95% CI, 1.16, 1.35), P<0.00001) and extraoral halitosis (I2 =0; RR=1.19 (95% CI, 1.08, 1.31), P=0.0004). Subgroup analysis and sensitivity analysis showed insignificant results. Conclusion. With the limitation of our study, both CM and CWM have significantly better effect on halitosis than WM. More effort should be made to explore long-term effect of CM and CWM on halitosis. This study was registered with the PROSPERO (ID: CRD42018107229).

scholarly journals The Effect of Botulinum TOxin Application if Neuro-Ophthalmological Indications on the Results of Schirmer’s Test and Tear Osmolarity

2019 ◽  
Vol 75 (2) ◽  
pp. 74-77
Author(s):  
Peter Žiak ◽  
Juraj Halička ◽  
Karolína Kapitánová ◽  
Peter Mojžíš
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin Type A ◽  
Botulinum Toxin Type ◽  
Orbicularis Oculi Muscle ◽  
Schirmer’S Test ◽  
Essential Blepharospasm ◽  
Long Term Effect ◽  
Significant Difference ◽  
The Mean

Botulinum toxin type A (BT-A) is used in the treatment of neuroophthalmologic disorders such as essential blepharospasm and facial hemispasm for more than 20 years. Although the long-term effect of repeated application of the BT-A was confirmed, the BT-A effect on tears production and retention is not clear. In our work we investigated whether applied BT-A in patients with blepharospasm and hemifacial spasm affect tears production. Tears quality was measured with Schirmer’s and tear osmolarity test during neuro-ophthalmologic diseases treatment, which was evaluated before and 14 days after application of BT-A (Botox inj, Allergan, Irvine, USA) into the orbicularis oculi muscle. BT-A doses of 16-18 U with unilateral and 32 to 36 U bilateral applications were used. The mean tear production in Schirmer’s test before BT-A application was 8.38 ± 0.63 mm, and 2 weeks after BT-A application was 7.12 ± 0,6 mm (n = 50). Tear osmolarity was 305.4 ± 9.2 mOsm before BT-A application, and 2 weeks after BT-A application it was 305.2 ± 8,6 mOsm (n = 13). We found significant difference between two groups in tear quantity (p < 0.012), but not quality (p > 0.05). Application of the BT-A reduced the amount of tears measured by Schirmer’s test. These results confirm rational basis of the empirical clinical experience where an artificial tears substitution is recommended for patients with neuro-ophthalmologic disorders treated by BT-A.

scholarly journals Liver transplantation in recipients with class III obesity: post-transplant outcomes and weight gain

2020 ◽  
Author(s):  
Daiki Soma ◽  
Yujin Park ◽  
Plamen Mihaylov ◽  
Burcin Ekser ◽  
Marwan Ghabril ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Weight Gain ◽  
The United States ◽  
Class Iii ◽  
Obesity Class ◽  
Post Transplant ◽  
Significant Difference ◽  
Class Iii Obesity ◽  
The Impact

Abstract BackgroundOver the past decades, there has been a dramatic increase in obesity in the United States. Several studies have reported conflicting results for the impact of obesity on outcomes of liver transplantation (LT). This study aims to assess the impact of severe obesity on outcomes of LT and change in body mass index (BMI) after transplantation.MethodsAll adult LT performed between July 2001 and December 2018 were reviewed. A retrospective analysis was conducted. BMI of recipients is subdivided into six categories: underweight, normal, overweight, class Ⅰ obesity, class Ⅱ obesity, and class Ⅲ obesity (<18.5; 18.5-24.9; 25‐29.9; 30‐34.9; 35‐39.9; ≥40 kg/m2, respectively). Survival outcomes were compared between each group. Post-transplant BMI was followed up in a sub-group of patients receiving LT from January 2008 to December 2018.ResultsAmong 2024 patients in the analytic cohort, 1.9% were underweight, 24.5% were normal, 32.6% were overweight, 25% were in class Ⅰ obesity, 9.3% were in class Ⅱ obesity, and 1.1% were in class Ⅲ obesity. There was no significant difference in patient and graft survival at 10-year follow-up with respect to recipient obesity. The 1, 3, 5, and 10-year graft and patient survivals in class Ⅲ obesity group were 97.0%, 92.1%, 87.0%, and 79.8% for patient survival and 94.4%, 85.1%, 79.8%, and 72.5% for graft survival.BMI of all groups except the underweight group declined in the first three months postoperatively. After the three months, BMI of all groups except the class Ⅲ obesity group returned to the pre LT level by two years and reached a plateau by five years. In patients with class Ⅲ obesity, there was a significant increase in body weight after long term follow up.ConclusionIn this study, class Ⅲ obesity is not associated with higher mortality. Obesity, including class Ⅲ obesity, should not be considered to be a contraindication to LT in the absence of other contraindications. Post-LT interventions are required to prevent significant weight gain in recipients with class Ⅲ obesity after transplantation.

Long Term and Low Dose Mifepristone in The Treatment of Uterine Leiomyoma

2021 ◽  
Vol 7 (5) ◽  
pp. 1681-1685
Author(s):  
Panpan Liu ◽  
Meifang Dou ◽  
Li’an Yi ◽  
Kemei Li ◽  
Fenghua Yan
Keyword(s):  
Uterine Leiomyoma ◽  
Adverse Reactions ◽  
Low Dose ◽  
Hot Flashes ◽  
Control Group ◽  
Observation Group ◽  
Conventional Dose ◽  
Long Term Effect ◽  
Significant Difference

To explore the long-term effect of low-dose mifepristone in the treatment of uterine leiomyoma. Methods: 90 cases of hysteromyoma treated in our hospital from December 2018 to May 2019 were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with conventional dose (25mg / D) of mifepristone, and the observation group with low dose (12.5mg / D) of mifepristone. The uterine volume, uterine fibroid volume, hormone level, therapeutic effect and adverse reactions were compared between the two groups. Results: After treatment, the volume of uterus and hysteromyoma in the two groups decreased significantly, but there was no significant difference between the observation group and the control group (P > 0.05); the level of E2, P, FSH in the two groups decreased, but there was no significant difference between the observation group and the control group (P > 0.05); the treatment effect of the observation group and the control group was no significant difference (P > 0.05); the adverse reactions of nausea, anorexia, hot flashes and fatigue in the observation group The birth rate was significantly lower than that of the control group (P < 0.05). Conclusion: Low dose mifepristone can also effectively reduce the level of estrogen and progesterone in patients with uterine leiomyoma, reduce the volume of leiomyoma, reduce the incidence of adverse reactions, with high safety, which is worthy of clinical application.

scholarly journals Long-Term Outcomes of Class III Treatment with Mandibular Cervical Headgear Followed by Fixed Appliances

2009 ◽  
Vol 79 (5) ◽  
pp. 828-834 ◽  
Author(s):  
Tiziano Baccetti ◽  
Diego Rey ◽  
Giovanni Oberti ◽  
Franka Stahl ◽  
James A. McNamara
Keyword(s):  
Skeletal Maturity ◽  
Control Group ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Two Phase ◽  
Fixed Appliance ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Fixed Appliances

Abstract Objective: To evaluate the stability of the outcomes of mandibular cervical headgear (MCH) and fixed appliance–treated Class III patients at a long-term posttreatment (5 years) observation, compared with well-matched untreated Class III controls, following a previous report on the short-term outcomes of this protocol. Materials and Methods: The treated group consisted of 20 patients with dentoskeletal Class III malocclusions treated with a two-phase protocol consisting of MCH and fixed appliances, while the control group comprised 18 untreated subjects with similar dentoskeletal Class III malocclusion. Lateral cephalograms of both patients and controls were analyzed at two time points: posttreatment (PT), after two-phase treatment; and long term (LT). All patients were at a postpubertal stage of skeletal maturity at PT, and they showed CS6 at LT, thus revealing completion of pubertal craniofacial growth. Results: In the long term, the treatment group showed significantly smaller values for mandibular length (Co-Gn), SNB angle, maxillomandibular differential, and molar relation. When compared with the controls, the treated patients exhibited also greater values for ANB angle, Wits appraisal, and overjet at LT. No significant difference between the two groups was found for the changes occurring from PT to LT. Conclusions: Favorable dentoskeletal outcomes induced by MCH and fixed appliances remained stable in the long term; untreated Class III malocclusion did not show any tendency toward self-improvement during the postpubertal interval.

scholarly journals THE INFLUENCE OF THE SAGITTAL DENTOSKELETAL PATTERN ON THE VALUE OF THE SOFT TISSUE PROFILE ANGLES - A CEPHALOMETRIC STUDY

2019 ◽  
pp. 048
Author(s):  
Tatjana Perović ◽  
Milena Blažej ◽  
Ivan Jovanović
Keyword(s):  
Soft Tissue ◽  
Class Ii ◽  
Class I ◽  
Class Iii ◽  
Lower Face ◽  
Soft Tissue Profile ◽  
Lateral Cephalograms ◽  
Division 1 ◽  
Cephalometric Study ◽  
Class Ii Division 1

The aim of this study has been to establish the values of soft tissue profile angles in subjects with dentoskeletal Class I, Class II Division 1, Class II Division 2, and Class III pattern, in order to examine the influence of sagittal dentoskeletal relation on the value of angular profile parameters. This comparative cephalometric study included the examination and the analysis by lateral cephalograms to evaluate soft tissue profile angles for 120 adult Caucasian subjects (60 women and 60 men) from the mid Balkan region divided into four groups towards ANB angle and incisors inclination. The following angles were examined: angle of facial convexity, facial convexity angle for the lower face and the angle of total facial convexity. By investigating the influence of the sagittal dentoskeletal pattern on the value of facial convexity angles, significant differences have been established between subjects with Class I and Class II Division 1 and 2 for all examined angles (p<0.001; p=0.011), while the differences between Class I and Class III are only significant for the facial convexity angle and facial convexity angle for the lower face, while the differences in the overall facial convexity angle are not significant (p=0.067). There are significant differences between subjects for all examined angles except the total facial convexity angle between Class I and Class III.

scholarly journals Long-Term Impact of Cyclosporin Reduction with MMF Treatment in Chronic Allograft Dysfunction: REFERENECE Study 3-Year Follow Up

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
L. Frimat ◽  
E. Cassuto-Viguier ◽  
F. Provôt ◽  
L. Rostaing ◽  
B. Charpentier ◽  
...  
Keyword(s):  
Kidney Function ◽  
Randomized Study ◽  
Control Group ◽  
Serious Adverse Events ◽  
Transplant Patients ◽  
Long Term Effect ◽  
Significant Difference ◽  
Long Term Impact

Calcineurin inhibitor (CNI) toxicity contributes to chronic allograft nephropathy (CAN). In the 2-year, randomized, study, we showed that 50% cyclosporin (CsA) reduction in combination with mycophenolate mofetil (MMF) treatment improves kidney function without increasing the risk for graft rejection/loss. To investigate the long-term effect of this regimen, we conducted a follow up study in 70 kidney transplant patients until 5 years after REFERENCE initiation. The improvement of kidney function was confirmed in the MMF group but not in the control group (CsA group). Four graft losses occurred, 2 in each group (graft survival in the MMF group 95.8% and 90.9% in control group). One death occurred in the control group. There was no statistically significant difference in the occurrence of serious adverse events or acute graft rejections. A limitation is the weak proportion of patient still remaining within the control group. On the other hand, REFERENCE focuses on the CsA regimen while opinions about the tacrolimus ones are still debated. In conclusion, CsA reduction in the presence of MMF treatment seems to maintain kidney function and is well tolerated in the long term.

Comparing Pharyngeal Airway Dimensions and Hyoid Bone Position in the Subgroups of Skeletal Class III Malocclusions: A Cephalometric Study

2020 ◽  
pp. 232020682096086
Author(s):  
MH Buyukcavus ◽  
G Kocakara
Keyword(s):  
Hyoid Bone ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Significance Level ◽  
Skeletal Class ◽  
Pharyngeal Airway ◽  
Significant Difference ◽  
Cephalometric Study ◽  
Post Hoc ◽  
Airway Dimensions

Aim: To examine pharyngeal airway dimensions and hyoid bone position according to the subgroups of Class III malocclusion. Materials and Methods: This retrospective study consisted of patients divided into three subgroups with skeletal Class III malocclusion. The study included a total of 151 individuals (61 females and 90 males). The authors divided individuals with skeletal Class III malocclusion into three subgroups: maxillary retrognathia, mandibular prognathia, and combined. The study’s cephalometric analysis used eight nasopharyngeal, seven oropharyngeal, two hypopharyngeal, nine hyoid, and four area measurements. One-way analysis of variance was used to evaluate patients. Tukey’s post-hoc tests were used for bilateral comparisons of significant parameters. The results were considered statistically significant at a P < .05 significance level. Results: The study found no significant differences between the groups’ pharyngeal airway and area measurements ( P > .05). When the authors evaluated hyoid bone position, a statistically significant difference was found between the three groups’ Hy-A (mm), Hy-S (mm), Hy-SN (mm), and Hy-FH (mm) measurements ( P < .05). Conclusion: Linear and areal pharyngeal airway dimensions are similar in subgroups of Class III malocclusions, while the hyoid bone is vertically higher in individuals with maxillary retrognathia.

Prepubertal Midface Growth in Unilateral Cleft Lip and Palate following Alveolar Molding and Gingivoperiosteoplasty

2004 ◽  
Vol 41 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Catherine T. H. Lee ◽  
Barry H. Grayson ◽  
Court B. Cutting ◽  
Lawrence E. Brecht ◽  
Wen Yuan Lin
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Permutation Test ◽  
Long Term Effect ◽  
Significant Difference ◽  
History Of ◽  
The Mean ◽  
Late Start ◽  
Nasoalveolar Molding

Objectives To examine the long-term effect of nasoalveolar molding and gingivoperiosteoplasty (modified Millard type) on midface growth at prepuberty. Procedures In this retrospective study, 20 consecutive patients with a history of complete unilateral cleft lip and palate were evaluated. Ten patients had nasoalveolar molding and gingivoperiosteoplasty performed at lip closure; 10 control patients had nasoalveolar molding but no gingivoperiosteoplasty because of late start in treatment or poor compliance. A single surgeon (C.B.C.) performed all surgical procedures. Standardized lateral cephalometric radiographs were evaluated at two time periods: T1 at pre–bone-grafting age and T2 at prepuberty age. Superimposition and cephalometric analysis were undertaken to investigate the two groups. Two cephalometric reference planes, sella-nasion and basion-nasion, were used to assess the vertical and sagittal relations of the midface (ANS-PNS). The reference landmarks were procrustes fitted. The mean location and variance of ANS and PNS landmarks were computed. All results were analyzed by permutation test. Results No significant difference in mean location or variance of ANS-PNS in both vertical and sagittal planes at both T1 and T2 periods were found between the two groups (p > .05). Conclusions The results suggested that midface growth in sagittal or vertical planes (up to the age of 9 to 13 years) were not affected by presurgical alveolar molding and gingivoperiosteoplasty (Millard type).

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