ANOMERIC SPECIFICITY OF GLUCOSE METABOLISM IN HEALTH AND DISEASE

2001 ◽  
Vol 56 (6) ◽  
pp. 337-340
Author(s):  
W.J. Malaisse
Keyword(s):  
Glucose Metabolism ◽  
Health And Disease ◽  
Anomeric Specificity

scholarly journals Regulation of hepatic glucose metabolism in health and disease

2017 ◽  
Vol 13 (10) ◽  
pp. 572-587 ◽  
Author(s):  
Max C. Petersen ◽  
Daniel F. Vatner ◽  
Gerald I. Shulman
Keyword(s):  
Glucose Metabolism ◽  
Hepatic Glucose Metabolism ◽  
Hepatic Glucose ◽  
Health And Disease

scholarly journals Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Kristian N. Mortensen ◽  
Albert Gjedde ◽  
Garth J. Thompson ◽  
Peter Herman ◽  
Maxime J. Parent ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Human Brain ◽  
Disease Biomarkers ◽  
Eyes Closed ◽  
Positron Emission ◽  
Congenitally Blind ◽  
Eyes Open ◽  
Health And Disease ◽  
The Impact ◽  
Global Mean

Because the human brain consumes a disproportionate fraction of the resting body’s energy, positron emission tomography (PET) measurements of absolute glucose metabolism (CMRglc) can serve as disease biomarkers. Global mean normalization (GMN) of PET data reveals disease-based differences from healthy individuals as fractional changes across regions relative to a global mean. To assess the impact of GMN applied to metabolic data, we compared CMRglc with and without GMN in healthy awake volunteers with eyes closed (i.e., control) against specific physiological/clinical states, including healthy/awake with eyes open, healthy/awake but congenitally blind, healthy/sedated with anesthetics, and patients with disorders of consciousness. Without GMN, global CMRglc alterations compared to control were detected in all conditions except in congenitally blind where regional CMRglc variations were detected in the visual cortex. However, GMN introduced regional and bidirectional CMRglc changes at smaller fractions of the quantitative delocalized changes. While global information was lost with GMN, the quantitative approach (i.e., a validated method for quantitative baseline metabolic activity without GMN) not only preserved global CMRglc alterations induced by opening eyes, sedation, and varying consciousness but also detected regional CMRglc variations in the congenitally blind. These results caution the use of GMN upon PET-measured CMRglc data in health and disease.

The effects of incretin hormones on cerebral glucose metabolism in health and disease

2018 ◽  
Vol 136 ◽  
pp. 243-250 ◽  
Author(s):  
Malin Nilsson ◽  
Albert Gjedde ◽  
Birgitte Brock ◽  
Michael Gejl ◽  
Jørgen Rungby
Keyword(s):  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Incretin Hormones ◽  
Health And Disease

scholarly journals Fat circadian biology

2009 ◽  
Vol 107 (5) ◽  
pp. 1629-1637 ◽  
Author(s):  
Jeffrey M. Gimble ◽  
Z. Elizabeth Floyd
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Tissue Differentiation ◽  
Regulatory Proteins ◽  
Secretory Function ◽  
Endocrine Organ ◽  
The Core ◽  
Concise Review ◽  
Growing Body ◽  
Health And Disease

While adipose tissue has long been recognized for its major role in metabolism, it is now appreciated as an endocrine organ. A growing body of literature has emerged that identifies circadian mechanisms as a critical regulator of adipose tissue differentiation, metabolism, and adipokine secretory function in both health and disease. This concise review focuses on recent data from murine and human models that highlights the interplay between the core circadian regulatory proteins and adipose tissue in the context of energy, fat, and glucose metabolism. It will be important to integrate circadian mechanisms and networks into future descriptions of adipose tissue physiology.

scholarly journals Anomeric specificity of glucose metabolism in the pentose cycle.

1985 ◽  
Vol 260 (27) ◽  
pp. 14630-14632
Author(s):  
W J Malaisse ◽  
M H Giroix ◽  
A Sener
Keyword(s):  
Glucose Metabolism ◽  
Anomeric Specificity

Anomeric specificity ofd-glucose metabolism in rat brain cells

1987 ◽  
Vol 419 (1-2) ◽  
pp. 147-155 ◽  
Author(s):  
Willy J. Malaisse ◽  
Francine Malaisse-Lagae
Keyword(s):  
Glucose Metabolism ◽  
Rat Brain ◽  
Brain Cells ◽  
Anomeric Specificity

scholarly journals Bile acids in glucose metabolism in health and disease

2018 ◽  
Vol 215 (2) ◽  
pp. 383-396 ◽  
Author(s):  
Hagit Shapiro ◽  
Aleksandra A. Kolodziejczyk ◽  
Daniel Halstuch ◽  
Eran Elinav
Keyword(s):  
Glucose Metabolism ◽  
Bile Acids ◽  
Glycogen Synthesis ◽  
Dietary Lipids ◽  
Farnesoid X Receptor ◽  
Morbidly Obese ◽  
Glycemic Response ◽  
Multiple Organs ◽  
Health And Disease ◽  
The Impact

Bile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling molecules controlling glucose, lipid, and energy metabolism by binding to the nuclear hormone farnesoid X receptor (FXR) and Takeda G protein receptor 5 (TGR5) in multiple organs, leading to regulation of intestinal incretin secretion, hepatic gluconeogenesis, glycogen synthesis, energy expenditure, inflammation, and gut microbiome configuration. Alterations in BA metabolism and signaling are associated with obesity and type 2 diabetes mellitus (T2DM), whereas treatment of T2DM patients with BA sequestrants, or bariatric surgery in morbidly obese patients, results in a significant improvement in glycemic response that is associated with changes in the BA profile and signaling. Herein, we review the roles of BAs in glucose metabolism in health and disease; highlight the limitations, unknowns, and challenges in understanding the impact of BAs on the glycemic response; and discuss how this knowledge may be harnessed to develop innovative therapeutic approaches for the treatment of hyperglycemia and diabetes.

scholarly journals Intestinal Fructose and Glucose Metabolism in Health and Disease

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 94 ◽  
Author(s):  
Beatriz Merino ◽  
Cristina M. Fernández-Díaz ◽  
Irene Cózar-Castellano ◽  
German Perdomo
Keyword(s):  
Glucose Metabolism ◽  
Intracellular Signaling ◽  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Sugar Metabolism ◽  
Sugar Consumption ◽  
Cellular Mechanisms ◽  
Obesity And Diabetes ◽  
Health And Disease ◽  
Dietary Sugars

The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed.

Anomeric specificity of enzymes of D-glucose metabolism

FEBS Letters ◽  
1974 ◽  
Vol 40 (S1) ◽  
pp. S105-S111 ◽  
Author(s):  
Bernd Wurster ◽  
Benno Hess
Keyword(s):  
Glucose Metabolism ◽  
Anomeric Specificity
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