Radioembolization with Yttrium-90 Microspheres for Pancreatic Cancer Liver Metastases: Results from a Pilot Study

2010 ◽  
Vol 96 (6) ◽  
pp. 955-958 ◽  
Author(s):  
Christopher Cao ◽  
Tristan D Yan ◽  
David L Morris ◽  
Lourens Bester
Keyword(s):  
Pancreatic Cancer ◽  
Pilot Study ◽  
Liver Metastases ◽  
Yttrium 90

scholarly journals Radioembolization with Yttrium-90 Microspheres (SIRT) in Pancreatic Cancer Patients with Liver Metastases: Efficacy, Safety and Prognostic Factors

Oncology ◽  
2014 ◽  
Vol 86 (1) ◽  
pp. 24-32 ◽  
Author(s):  
M. Michl ◽  
A.R. Haug ◽  
T.F. Jakobs ◽  
P. Paprottka ◽  
R.-T. Hoffmann ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Prognostic Factors ◽  
Liver Metastases ◽  
Cancer Patients ◽  
Yttrium 90

PILOT STUDY DETERMINING THE FEASIBILITY OF DIAGNOSING PANCREATIC CANCER USING SINGLE CELL PARTIAL WAVE SPECTROSCOPY OF THE DUODENAL MUCOSA

Pancreas ◽  
2007 ◽  
Vol 35 (4) ◽  
pp. 429-430
Author(s):  
H. Subramanian ◽  
R. Brand ◽  
P. Pradhan ◽  
N. Deep ◽  
V. Parikh ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pilot Study ◽  
Single Cell ◽  
Partial Wave ◽  
Duodenal Mucosa ◽  
Partial Wave Spectroscopy

scholarly journals Yttrium-90 radioembolization of isolated hepatic adrenocortical carcinoma metastases with negative surgical pathology

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sen Lu ◽  
Jasreman Dhillon ◽  
Julie Hallanger Johnson ◽  
Ghassan El-Haddad
Keyword(s):  
Liver Metastases ◽  
Adrenocortical Carcinoma ◽  
Hepatic Metastases ◽  
Tumor Board ◽  
Adrenal Crisis ◽  
Tumor Control ◽  
Inferior Phrenic Artery ◽  
Post Surgery ◽  
Stage 4 ◽  
Yttrium 90

Abstract Background Adrenocortical carcinoma (ACC) is an uncommon malignancy with an estimated 15,400 new cases annually across the globe. The prognosis is generally poor as the disease is often already advanced at initial diagnosis due to non-specific symptoms. Even for local disease, recurrence after surgical resection is high. Treatment choices for advanced disease include mitotane, chemotherapy, ablation, chemoembolization, radioembolization, and external beam radiotherapy, with varying degrees of efficacy. To the best of our knowledge, there have only been two prior case studies of complete clinical and radiological response of stage 4 disease at 1 year and 2 years after yttrium-90 (90Y) microsphere selective internal radiation therapy (SIRT) of isolated hepatic metastases post-surgery and chemotherapy. Case presentation We present a case of a 58-year-old man with metastatic ACC who was treated with 90Y resin microsphere (SIR-spheres) for local control of liver metastases leading to a surgically proven negative pathology after partial hepatectomy 7 months after SIRT. The patient was initially diagnosed with stage 1 ACC that progressed 6 years later to stage 4 disease with new liver metastases that were deemed unresectable at an outside institution. After review of the case at multidisciplinary tumor board, he was referred for liver directed therapy for local tumor control. Angiographic workup demonstrated partial extrahepatic supply to the tumors from the right inferior phrenic artery, which was successfully embolized on the day of SIRT for flow redistribution. As the patient was being treated with mitotane that suppresses steroid production, he developed post-SIRT adrenal crisis, which was successfully controlled with steroids, highlighting the need for pre SIRT stress dose steroids. Conclusions This case continues to add to the literature supporting 90Y radioembolization as an effective treatment for isolated hepatic ACC metastases. Our case is the first to demonstrate surgically proven negative pathology after radioembolization. Further prospective study is warranted to better establish efficacy as well as safety of SIRT for ACC liver metastases.

scholarly journals Yttrium-90 radioembolization for colorectal cancer liver metastases in KRAS wild-type and mutant patients: Clinical and ccfDNA studies

2016 ◽  
Vol 37 (1) ◽  
pp. 57-65 ◽  
Author(s):  
E. Janowski ◽  
O. Timofeeva ◽  
S. Chasovskikh ◽  
M. Goldberg ◽  
A. Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Wild Type ◽  
Colorectal Cancer Liver Metastases ◽  
Yttrium 90
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