Effect of Endodontic Treatment on Serum Glutathione (GSH) Levels in Patients with Chronic Apical Periodontitis: A Clinical Pilot Study

2020 ◽  
pp. 232020682095823
Author(s):  
Rhythm Bains ◽  
Aseem P. Tikku ◽  
Anil Chandra ◽  
Wahid Ali ◽  
Promila Verma
Keyword(s):  
Venous Blood ◽  
Time Frame ◽  
Apical Periodontitis ◽  
Post Treatment ◽  
Endodontic Treatment ◽  
Female Group ◽  
Oxidative Balance ◽  
Before And After ◽  
The Mean ◽  
The Difference

Aim: To assess the before- and after-treatment levels of glutathione (GSH) in the serum of patients with chronic apical periodontitis. Materials and Methods: The study involved 20 systemically healthy patients with radiographic evidence of chronic apical periodontitis in at least one tooth, of which 11 were finally assessed. 10 mL of the patient’s venous blood was obtained before commencing the endodontic treatment to assess the pre-operative serum GSH levels (T0). The canals cleaned and shaped, and irrigated with 2.5% sodium hypochlorite, and filled with a calcium hydroxide based intracanal medicament. At the subsequent appointment after one week, teeth were obturated. The patients were recalled 30 days after the completion of endodontic therapy, and blood samples were assessed again at time frame T1 for serum GSH. The difference in pre- and post-treatment values for T0 and T1 was statistically analyzed. Results: The mean age of the subjects ( N = 11) was 21.09±3.24 years, with 19.50±0.71 years in female group and 21.44±3.50 years in the male group. The mean GSH at T0 was 11.73±8.30 units, which was increased to 14.04±13.96 units at T1. However, no significant change was observed in the GSH level from T0 to T1 (change = –2.30, t-value = –0.49, P = .635). Conclusion: The results of this study suggest that endodontic therapy may play a role in restoring the systemic oxidative balance, as seen by the increase in post-treatment serum GSH levels.

scholarly journals PERBEDAAN KADAR TRIGLISERIDA WANITA SEBELUM DAN SESUDAH TERAPI BEKAM

2019 ◽  
Vol 12 (2) ◽  
pp. 45-51
Author(s):  
Diana Fransiska Sinaga ◽  
Putri Widelia Welkriana ◽  
Jon Farizal
Keyword(s):  
Alternative Medicine ◽  
Triglyceride Level ◽  
Venous Blood ◽  
Mean Value ◽  
Cupping Therapy ◽  
Test Analysis ◽  
Blood Biochemical ◽  
Before And After ◽  
The Mean ◽  
The Difference

Background: Wet cupping therapy can excavate the hydrophilic and hydrophobic material one example is lipoprotein. Triglycerides are used as blood biochemical parameters to determine the interference of fat metabolism. Hypertriglyceridemia is a condition that occurs because of increased triglyceride levels that trigger the accumulation of lipids in the walls of the arteries that can cause atherosclerosis. Objective: This research is to know the difference of triglyceride level of women before and after cupping therapy at Cottage Alternative Medicine Miftahussyifa Bengkulu City. Methods: The research conducted is Analytical. The research design used was researched design pre-experimental with one group pre-post test. The sample in this study were 32 respondents by using purposive sampling method. Samples were measured by method clinical analyzer using a clinical analyzer instrument (Architect Plus C4000®) and using triglyceride reagent (proliferation Abbot Architect Plus C4000®). Results: This study showed that of 32 female respondents who had first followed bruise therapy then examined triglyceride levels before and after cupping therapy with the first venous blood taking done before the cordoning, the second venous blood taking was done immediately after the curing of the same sample. The result showed that the mean of triglyceride level before and after cupping therapy decreased with the mean value of triglyceride level before cupping therapy 208,28 mg / dL and mean value of triglyceride level after cupping therapy 200,59 mg / dL. The result of T-test analysis is dependent with value p =0,002 (p <0,05). Conclusion: There are significant differences in triglyceride levels before and after cupping therapy at Cottage Alternative Medicine Miftahussyifa Bengkulu City.

scholarly journals Influence of Apical Patency and Cleaning of the Apical Foramen on Periapical Extrusion in Retreatment

2013 ◽  
Vol 24 (5) ◽  
pp. 482-486 ◽  
Author(s):  
Marili Doro Andrade Deonizio ◽  
Gilson Blitzkow Sydney ◽  
Antonio Batista ◽  
Roberto Pontarolo ◽  
Paulo Ricardo Bittencourt Guimarães ◽  
...  
Keyword(s):  
Material Removal ◽  
Filling Material ◽  
Mean Values ◽  
Filtration System ◽  
Root Canal Retreatment ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
Removal Technique

This study evaluated the influence of apical patency, root filling removal technique and cleaning of the apical foramen, concerning the amount of debris extruded during root canal retreatment. Forty mandibular incisors were randomly assigned to 4 groups - GIM (n=10), GIIM (n=10), GIPT (n=10) and GIIPT (n=10), which were named according to leaving (I) or not (II) apical patency during canal preparation and filling removal technique (manual - M or ProTaper system - PT). After filling material removal, each specimen of each group had the apical foramen cleaned by sizes 15, 20 and 25 instruments, generating 12 subgroups: GIM15, GIM20, GIM25, GIIM15, GIIM20, GIIM25, GIPT15, GIPT20, GIPT25, GIIPT15, GIIPT20 and GIIPT25. Extruded filling debris was collected by a Milipore filtration system, an HV-durapore, 0.45 µm pore filter with a 25 mm diameter. The filters were weighed before and after the collection on an analytical scale (10–5 g), and the difference was calculated. The mean weight of extruded filling debris was analyzed statistically by Kruskal-Wallis and Friedman ANOVA tests (α=0.05). The mean values found in the groups (in mg) were: GIM (0.95±0.94), GIIM (0.47±0.62), GIPT (0.30±0.31) and GIIPT (0.32±0.44). There was no statistically significant difference among any of the groups or subgroups (p>0.05). ProTaper provided the smallest amount of extruded filling material, regardless of presence or absence of apical patency, followed by manual technique, without and with apical patency. Additional amounts of debris were collected during cleaning of the apical foramen, regardless of the instrument, presence/absence of patency or root filling removal technique.

scholarly journals Audio-visual media to improve sexual-reproduction health knowledge among adolescent

2020 ◽  
Vol 9 (1) ◽  
pp. 138
Author(s):  
Sitti Nur Djannah ◽  
Sulistyawati Sulistyawati ◽  
Tri Wahyuni Sukesi ◽  
Surahma Asti Mulasari ◽  
Fatwa Tentama
Keyword(s):  
Sexual Reproduction ◽  
Junior High School ◽  
Health Knowledge ◽  
Visual Media ◽  
Wilcoxon Test ◽  
Post Intervention ◽  
Before And After ◽  
The Mean ◽  
The Difference ◽  
Source Of Information

<span>Lacking knowledge among adolescents affects their understanding of some problems related to sexual-reproduction health. Electronic media recognized as the favored source of information for adolescents. This research aimed to assess the effect of audio-visual media to the increasing of sexual-reproduction knowledge. We conducted a before and after without control informal experimental study design into 153 students in the 1st-3rd grade of junior high school. The effect of the intervention was assessed through the difference between pre- and post-intervention by using the Wilcoxon test. The mean score of the respondent pre and post-intervention was significantly increasing. The audiovisual increased the knowledge of the adolescent regarding sexual-reproduction health</span>

scholarly journals Photogrammetric avalanche volume measurements at Vallée de la Sionne, Switzerland

2001 ◽  
Vol 32 ◽  
pp. 141-146 ◽  
Author(s):  
Juauien Vallet ◽  
Urs Gruber ◽  
François Dufour
Keyword(s):  
Large Scale ◽  
Field Experiments ◽  
Test Site ◽  
Deposition Zone ◽  
Before And After ◽  
Large Scale Field ◽  
Volume Measurements ◽  
Snow Distribution ◽  
The Mean ◽  
The Difference

AbstractDuring winter 1999 three large avalanche events were triggered by explosives at SLF’s avalanche test site, Vallée de la Sionne, canton Valais, Switzerland. One important goal of these large-scale field experiments was to measure the release and deposition volumes of avalanches by photogrammetric methods. In this paper, the photogrammetric measurements of all three avalanches are summarized. For one avalanche event it was possible to realize the whole measuring procedure as planned, and to obtain volume measurements before and after the avalanche triggering In the other two avalanche events, the photographs before the triggering of the avalanche failed. Nevertheless the photographs taken after the avalanche provide valuable information on the fracture depth at the fracture line. The mean fracture depth of the largest avalanche was about 2.10 m, varying between 1 and 3.5 m over a width of > 1000 m. The total volume of the deposition of all three avalanche events was about 1300 000 m3. The deposits are distributed over a length of > 1000 m with depths up to 30 m. The difference between the released and deposited volumes proved that avalanches entrain a large amount of snow along the avalanche track. Furthermore, the snow distribution in the deposition zone provides important information about the behaviour of a dense flowing avalanche in the runout zone.

Fluid and electrolyte shifts in women during +Gz acceleration after 15 days' bed rest

1977 ◽  
Vol 42 (1) ◽  
pp. 67-73 ◽  
Author(s):  
J. E. Greenleaf ◽  
H. O. Stinnett ◽  
G. L. Davis ◽  
J. Kollias ◽  
E. M. Bernauer
Keyword(s):  
Mean Corpuscular Volume ◽  
Body Position ◽  
Venous Blood ◽  
Bed Rest ◽  
Corpuscular Volume ◽  
The Third ◽  
Before And After ◽  
The Mean ◽  
Electrolyte Loss ◽  
Reduced Activity

Twelve women (23–34 yr), comprising a bed-rest (BR) group of eight subjects and an ambulatory (AMB) group of four subjects, were centrifuged after 14 days of ambulatory control (C),after 15 days of a 17-day BR period, and on the third day of recovery (R). Venous blood was taken before and after the third +3.0 G acceleration run (1.8 G/min). Relative to (C), the +Gz tolerance after BR was reduced -49.0% (P less than 0.05) in the BR group and -38.7% (NS) in the AMB group; during (R) the BR group regained up to 89.4% and the AMB group up to 87.1% of their (C) tolerances. In each of the three test periods, the shifts in plasma Na, Cl, PO4, and osmotic contents, which accompanied +Gz, followed the outward shift of plasma volume (PV). The correlation of the shift of PV during acceleration with the +Gz tolerance was 0.72 (P less than 0.01). During acceleration, the PV and electrolyte loss for both groups after BR was about half the loss of (C) and (R). Compared with (C) and (R) values, potassium shifts were variable but the mean corpuscular volume and mean corpuscular Hb contents and concentrations were unchanged during all +Gz runs; The results indicate that: 1) the higher the (C) + Gz tolerance, the greater the tolerance decline due to BR; 2) relative confinement and reduced activity contribute as much to the reduction in tolerance as does the horizontal body position during BR; 3) bed-rest deconditioning has no effect on the erythrocyte volume during +3.0 Gz; and 4) about one-half the loss in tolerance after BR can be attributed to PV and electrolyte shifts.

OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study

2020 ◽  
pp. 112067212096345
Author(s):  
Marco Lupidi ◽  
Ramkailash Gujar ◽  
Alessio Cerquaglia ◽  
Jay Chhablani ◽  
Daniela Fruttini ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Additional Treatment ◽  
Post Treatment ◽  
Vascular Perfusion ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Pre Treatment ◽  
Induced Changes

Purpose: To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A). Methods: Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion. Results: Fifteen eyes of 13 patients with PDR were enrolled. The mean area of the RNVs was 0.47 ± 0.50 mm2 in the baseline OCT-A and 0.32 ± 0.40 mm2 in the post-treatment assessment ( p = 0.0002). The mean RNV VPD of RNV was 2% ± 4% in pre-treatment and 1% ± 1% for the post-treatment ( p = 0.0001). The mean VLD of RNV was 7.26 ± 1.53 at baseline and 6.64 ± 1.65 in the post treatment ( p = 0.0002). A significant difference in terms of mean RNVs area and VPD reduction between eyes that needed additional treatment and those that did not (~40% vs ~20%; p < 0.05), was observed. Mean VPD of full-retinal thickness OCT-angiogram was 55% ± 10% for the pre-treatment and 53% ± 8% for the post treatment scan ( p = 0.02). Conclusion: The quantitative OCT-A assessment of laser-induced changes of RNVs can be a useful non-invasive approach for determining treatment efficacy. A reduction of RNVs area or VPD ⩾ 40% might reveal those eyes that won’t require additional treatment. Retinal perfusion impairment seemed to progress independently from the treatment.

Is alveolar carbon monoxide an unreliable index of carboxyhaemoglobin changes during smoking in man?

1988 ◽  
Vol 74 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Andrew R. Guyatt ◽  
Andrew J. T. Kirkham ◽  
Derek C. Mariner ◽  
Gordon Cumming
Keyword(s):  
Carbon Monoxide ◽  
Breath Holding ◽  
Gas Mixture ◽  
Transient Change ◽  
Holding Period ◽  
Before And After ◽  
The Subject ◽  
The Mean ◽  
The Difference ◽  
Co Gas

1. We measured alveolar carbon monoxide (CO) after a 20 s breath-holding period and carboxyhaemoglobin both before and after smoking a cigarette on 500 occasions (101 individuals). The two measurements were closely correlated but there was a marked difference in the change or ‘boost’ after smoking one cigarette. The mean relative boosts ([post value—pre value]/[pre + post]/2) for alveolar CO and carboxyhaemoglobin were 7.7% and 20.3%, while negative boosts (fall rather than the expected rise) were seen in 103 of 500 and three of 500 occasions respectively. In 140 studies a third alveolar CO reading taken 5 min later was slightly larger, but the difference was insignificant. 2. In seven subjects where the carboxyhaemoglobin level was raised by breathing a 2% CO gas mixture, the alveolar CO and carboxyhaemglobin boosts were similar (71.7% and 75.2% respectively), and they fell sharply subsequently rather than increasing further as occurred after smoking. 3. We conclude that alveolar CO measurements give a useful estimate of carboxyhaemoglobin level if the subject has not smoked for at least half an hour but that measurements of alveolar CO boost are useless since the act of smoking interferes with alveolar sampling. We postulate that cigarette smoking induces a transient change in pulmonary gas exchange.

Phase II breast cancer chemoprevention study with celecoxib in women at increased risk for breast cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 1010-1010
Author(s):  
B. Arun ◽  
V. Valero ◽  
G. Yin ◽  
G. Babiera ◽  
J. L. Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Atypical Hyperplasia ◽  
Post Treatment ◽  
Short Term ◽  
Ki 67 ◽  
High Risk Women ◽  
Before And After ◽  
The Difference ◽  
Er Expression

1010 Background: Short-term chemoprevention trials offer a convenient model to screen chemopreventive agents and identify endpoint biomarkers. One of the potential agents is celecoxib (C), which has antiproliferative and apoptosis inducing properties. In this prospective study, our primary aim was to evaluate changes in proliferation induced by C in breast tissue of high risk women. Here, we report changes in estrogen receptor (ER) proliferation index. Methods: 42 eligible high risk women were enrolled into the study, underwent fine needle aspiration (FNA) and started celecoxib treatment at 400 mg BID. Median age: 51.9 years. Risk factors: Gail risk > 1.67% (n=13), lobular carcinoma insitu (n=13), atypical hyperplasia (n=11), previous history of breast cancer (n=5). For ER and Ki-67 testing, thin preparations slides were incubated with primary mouse monoclonal antibody 6F11 against the ER and clone MIB-1, respectively. Appropriate negative and positive controls were included. At least 100 epithelial cells were evaluated per slide. Immunoreactivity for each marker was scored as the percentage of positive nuclei. We assessed the difference in ER and Ki-67 levels before and after treatment using a Wilcoxon signed rank test. Results: The average pre-treatment ER expression in FNA samples was 35.9% and Ki-67 was 2.4%. 19 (45%) showed hyperplasia or atypical hyperplasia. 39 patients underwent also post-treatment FNAs. The pre-and post treatment ER expression in this group was 35.7% (range 0–100%) and 27.4% (range: 0–100%), respectively. The difference in ER levels was statistically significant (p = 0.04). Twenty-six patients had Ki-67 levels measured both before and after treatment. The median difference in Ki-67 levels was 0 (range 0- 5). This change was not statistically significant (p = 0.63). Conclusions: We have completed accrual to a prospective short-term chemoprevention trial with celecoxib. We have found a significant downregulation of ER expression with 6 months celecoxib. Since ER expression is a marker of proliferation, this finding confirms celecoxibs antiproliferative properties. Currently, we have not observed a change in Ki-67; this could be partly due to the small number of samples and the fact that Ki-67 is low in normal epithelium. [Table: see text]

scholarly journals The Difference Of Visual Acuity And Macular Thickness Post Bevacizumab Therapy In Secondary Macular Edema Retinal Vein Occlusion

2018 ◽  
Vol 4 (2) ◽  
pp. 110
Author(s):  
Citra Rahmadani ◽  
Nur Khoma Fatmawati ◽  
Rahmat Bakhtiar
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Secondary Data ◽  
Macular Thickness ◽  
Vein Occlusion ◽  
Before And After ◽  
Quasi Experimental ◽  
The Mean ◽  
The Difference

Retinal vein occlusion is the second most common cause of blindness in retinal vascular disease after diabetic retinopathy and may lead to complications of macular edema. Bevacizumab is an influential treatment as an anti vascular endothelial growth factor (VEGF). This study aims to determine the difference of visual acuity and macular thickness before and after treatment of Bevacizumab. This is a quasi experimental study in patients with secondary macular edema retinal vein occlusion who meets the inclusion criteria. Visual acuity and macular thickness were evaluated after one month of treatment. This study was conducted for two months since May-June 2017 by collecting secondary data from medical record at SMEC Samarinda from January 2016 – June 2017. Data were analyzed using Wilcoxon. Sixteen eyes from 16 patients were diagnosed with macular edema secondary retinal vein occlusion given bevacizumab treatment. The mean visual acuity before therapy was 1.106 LogMAR ± 0.509 and increased to 0.889 logMAR ± 0.608 (p = 0.116) after treatment while the mean macular thickness before therapy was 504.06 μm ± 301.273 and decreased to 348.81 μm ± 181.17 (p = 0.017) after treatment. There was a significant effect on the decrease in macular thickness but no significant effect on visual acuity improvement in patients with macular edema secondary retinal vein occlusion at SMEC Samarinda.  Keywords: Retinal vein occlusion, macular edema, bevacizumab

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