scholarly journals Process Automation toward Ultra-High-Throughput Screening of Combinatorial One-Bead-One-Compound (OBOC) Peptide Libraries

2012 ◽  
Vol 17 (3) ◽  
pp. 186-200 ◽  
Author(s):  
Junhoe Cha ◽  
Jaehong Lim ◽  
Yiran Zheng ◽  
Sylvia Tan ◽  
Yi Li Ang ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Peptide Libraries ◽  
Process Automation

Stacker Modules Used in a High-Capacity Robotics System for High Throughput Screening Compound Replication

1999 ◽  
Vol 4 (6) ◽  
pp. 373-379 ◽  
Author(s):  
Mark Beggs ◽  
Herman Blok ◽  
Jan Mertens
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
High Capacity ◽  
Robotic System ◽  
Throughput Capacity ◽  
Process Automation ◽  
Technology Process ◽  
Human Operators ◽  
Automation Project ◽  
Logistics Control

High throughput screening is now established as a key component of the pharmaceutical lead identification process in many pharmaceutical companies. Over recent years, thanks to advances in assay technology, process automation, and logistics control, the throughput capacity of HTS groups has increased significantly. It is now entirely possible to screen corporate compound collections against an individual pharmacological target within a timescale of several weeks. Despite these improvements, many HTS groups find that their capacity is limited by the rate at which they can provide test compounds in a "screen-ready" format. This limitation is usually imposed by the capacity and productivity of the single-armed robotic systems utilized. We have recently constructed a robotic system aimed at overcoming this particular problem. This system uses purpose-built microplate stacker units that provide high-capacity microplate storage and, importantly, provide an easy and fast interface between the robotic system and the human operators. This paper describes this automation project and the benefits that have resulted from its deployment.

scholarly journals An efficient strategy to enhance binding affinity and specificity of a known isozyme inhibitor

2016 ◽  
Vol 14 (28) ◽  
pp. 6833-6839 ◽  
Author(s):  
Joo-Eun Jee ◽  
Jaehong Lim ◽  
Yong Siang Ong ◽  
Jessica Oon ◽  
Liqian Gao ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Affinity ◽  
High Throughput ◽  
High Throughput Screening ◽  
Peptide Libraries ◽  
Binding Profile ◽  
Efficient Strategy

The binding profile of a known inhibitor, benzenesulfonamide, against a family of carbonic anhydrase isozymes was efficiently enhanced via high-throughput screening of customized combinatorial one-bead-one-compound peptide libraries.

High-Throughput Screening of One-Bead–One-Compound Peptide Libraries Using Intact Cells

2013 ◽  
Vol 15 (8) ◽  
pp. 393-400 ◽  
Author(s):  
Choi-Fong Cho ◽  
Babak Behnam Azad ◽  
Leonard G. Luyt ◽  
John D. Lewis
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Peptide Libraries ◽  
Intact Cells
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