scholarly journals Rosai-dorfman disease of the fibula: A case report

2019 ◽  
Vol 26 (2) ◽  
pp. 108-113
Author(s):  
Glen Purnomo ◽  
Jesus Adrian A Dueñas ◽  
Richard S Rotor ◽  
Rafael S Claudio
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Immunohistochemical Staining ◽  
Cervical Lymphadenopathy ◽  
Skeletal System ◽  
Rosai Dorfman Disease

Rosai–Dorfman disease (RDD) is usually characterized by painless bilateral cervical lymphadenopathy associated with fever and leukocytosis. Although the disease may occur outside lymphnodes, manifestation of skeletal system occurs in less than 8% of cases. In addition, presentation of this disease in a purely skeletal form without lymph nodes involvement is extremely uncommon. This case report describes a 17-year-old female with a pure skeletal presentation of RDD in the fibula. Trocar biopsy was performed, and immunohistochemical staining using S100 and CD68 was done to confirm the diagnosis.

scholarly journals Rosai-Dorfman disease presenting with extensive cutaneous manifestation - Case report

2013 ◽  
Vol 88 (2) ◽  
pp. 256-259 ◽  
Author(s):  
Paula Azevedo Borges Leal ◽  
Adrilena Lopes Adriano ◽  
Marcelle Parente Breckenfeld ◽  
Igor Santos Costa ◽  
Antônio Renê Diógenes de Sousa ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Cutaneous Manifestation ◽  
Common Site ◽  
Atypical Case ◽  
Inguinal Lymph Nodes ◽  
Rosai Dorfman Disease ◽  
Polyclonal Gammopathy ◽  
Extranodal Manifestations

Rosai-Dorfman disease is a benign, self-limited, idiopathic proliferative histiocytic disorder. It was first described in 1969 by Rosai and Dorfman. In its typical form the disease is characterized by extensive cervical lymphadenopathy associated with fever, polyclonal gammopathy and leukocytosis with neutrophilia. The skin is the most common site affected. Extranodal manifestations have been reported in 43% of cases. In this study, we report an atypical case of Rosai-Dorfman disease in a female with massive cutaneous manifestation on the thigh, associated with a minimal lymphadenopathy limited to the regional inguinal lymph nodes.

scholarly journals A unique combination of Rosai-Dorfman disease and mycosis fungoides: a case report

2018 ◽  
Vol 6 ◽  
pp. 2050313X1877219 ◽  
Author(s):  
Amanda J Shelley ◽  
Nordau Kanigsberg
Keyword(s):  
Case Report ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
Cervical Lymphadenopathy ◽  
B Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Unknown Etiology ◽  
Unique Combination ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease (RDD) is a rare histiocytic condition of unknown etiology. Patients with RDD classically present with massive painless cervical lymphadenopathy. However, extra-nodal disease occurs in approximately 40% of cases, with the skin being among the most commonly involved sites. Patients with isolated extra-nodal involvement may present without adenopathy. Reports of RDD occurring in patients with Hodgkin’s lymphoma, and B-cell lymphoma have been published, but there has only been one previous report of RDD in a patient with a T-cell lymphoma. This case report documents a unique combination of RDD and mycosis fungoides (MF), a cutaneous T cell lymphoma. This report also highlights diagnostic challenges in RDD due to the rarity of the condition and its variable presentation.

Extranodal Rosai-Dorfman Disease with Multifocal Bone and Epidural Involvement Causing Recurrent Spinal Cord Compression

2005 ◽  
Vol 8 (5) ◽  
pp. 593-598 ◽  
Author(s):  
Khulood Al-Saad ◽  
Paul Thorner ◽  
Bo-Yee Ngan ◽  
J. Ted Gerstle ◽  
Abhaya V. Kulkarni ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Lymph Nodes ◽  
S100 Protein ◽  
Cervical Lymphadenopathy ◽  
Cord Compression ◽  
Diagnostic Dilemma ◽  
Clinical Behavior ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Consultation Services

Sinus histocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare histiocytic disorder that typically presents with chronic, self-limiting, cervical lymphadenopathy. We present a case, a diagnostic dilemma for multiple consultation services, of an otherwise well 17-year-old boy without lymphadenopathy who, 8 months after excision of a T9 lytic vertebral lesion and epidural mass that caused cord compression, again presented with cord compression from progressive vertebral disease, recurrent epidural mass, and development of a paraspinal mass and tibial lesion. The excised vertebral and epidural lesions, 2 paraspinal biopsies, and tibial biopsy were interpreted as chronic inflammation until large histiocytes were noted, which were positive for CD68, S100 protein, fascin, and MAC387, and demonstrated characteristic emperipolesis (lymphophagocytosis) that was diagnostic of Rosai-Dorfman disease. This atypical clinical behavior and sites of involvement of multiple bones but not of lymph nodes is unusual and constitutes the aggressive end of the clinical spectrum and a rare cause for cord compression.

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2021 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

scholarly journals Rosai-Dorfman disease as a rare cause of cervical lymphadenopathy – case report and literature review

2018 ◽  
Vol 43 (3) ◽  
pp. 341-345 ◽  
Author(s):  
Aleksandra Miękus ◽  
Joanna Stefanowicz ◽  
Grażyna Kobierska-Gulida ◽  
Elżbieta Adamkiewicz-Drożyńska
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cervical Lymphadenopathy ◽  
Rosai Dorfman Disease

scholarly journals Case Report: Rosai-Dorfman Disease Involving Sellar Region in a Pediatric Patient: A Case Report and Systematic Review of Literature

2020 ◽  
Vol 7 ◽  
Author(s):  
Yi Zhang ◽  
Jie Liu ◽  
Jianyu Zhu ◽  
Xiang Zhou ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Pediatric Patient ◽  
Cervical Lymphadenopathy ◽  
Sellar Region ◽  
Rosai Dorfman Disease ◽  
The Individual ◽  
Mass Lesions ◽  
Endocrine Abnormality

Rosai-Dorfman disease (RDD) is an extremely rare histiocytic disorder characterized by cervical lymphadenopathy, while the involvement of sellar region is less observed. Here we report a pediatric patient who was initially suspected as sellar germinoma but later identified as RDD. We also conducted a systematic review about RDD involving sellar region. A total of only 14 cases were included and analyzed in our study in terms of clinical presentation, endocrine abnormality, radiological features, pathology, treatment, and follow up. The most common neurological manifestations of sellar RDD is diabetes insipidus and visual changes. Two typical kinds of MRI manifestations were presented in sellar RDD; one is like meningioma-like mass lesions, another showing infiltrative pattern that demonstrates hyperintense areas on T2WI. Currently, the treatment of RDD is tailored to the individual clinical circumstances. For sellar RDD, surgical treatment can be considered to completely remove or debulk the tumor.

scholarly journals Isolated Intracranial Rosai-Dorfman Disease Mimicking Suprasellar Meningioma: Case Report with Review of the Literature

2008 ◽  
Vol 36 (5) ◽  
pp. 1134-1139 ◽  
Author(s):  
S Swan ◽  
X Teng ◽  
R Zhan ◽  
J Yu ◽  
J Gu ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Definitive Diagnosis ◽  
Review Of The Literature ◽  
Radiological Features ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease (RDD) is an idiopathic histiocytic proliferation affecting the lymph nodes. Isolated intracranial RDD is rare and usually appears as a well-defined, dural-based lesion without lymphadenopathy. The clinical and radiological features of intracranial RDD are similar to meningioma. Histopathology and immunohistochemistry are essential for a definitive diagnosis. This is a report of a 43-year old male with isolated intracranial RDD, which manifested as a suprasellar meningioma. The clinical, radiological and pathological aspects of the disease are discussed within the context of a review of previously reported cases.

scholarly journals Rosai-Dorfman Disease: A Case Report of Asymptomatic Isolated Renal Involvement

2021 ◽  
Author(s):  
Alireza Abrishami ◽  
Pardis Ziaeefar ◽  
Sara Ebrahimi ◽  
Nastaran Khalili ◽  
Akbar Nouralizadeh ◽  
...  
Keyword(s):  
Case Report ◽  
Mortality Rate ◽  
Renal Involvement ◽  
Cervical Lymphadenopathy ◽  
Good Prognosis ◽  
Malignant Histiocytosis ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease (RDD) is a rare non-malignant histiocytosis disorder, commonly manifesting with massive painless cervical lymphadenopathy. Renal involvement develops in only four percent of patients with RDD. Generally, RDD is self-limiting and has a good prognosis; however, in patients with renal involvement, mortality rate can be as high as 40%.

scholarly journals A Case Report: Rosai Dorfman Disease

2020 ◽  
Vol 3 (02) ◽  
pp. 47-49
Author(s):  
Farida Yasmin ◽  
Abu Naser Mohammad Al-Amin ◽  
Ferdousi Begum ◽  
Ashis kumar Ghosh ◽  
M Rashed Z Kabir ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Clinical Course ◽  
Neck Region ◽  
The Body ◽  
Nodal Involvement ◽  
Orbital Mass ◽  
Head And Neck Region ◽  
Rosai Dorfman Disease ◽  
Abnormal Accumulation

Rosai-Dorfman Disease (RDD) is a rare disorder which usually associated with enlargement various superficial or deep lymph nodes. Clinical course of this disease is prolonged with exacerbation and remission phases occasionally. Over-production and accumulation of a specific type of white blood cell called histiocyte occurred in the lymph nodes of the body, mostly on the the neck. Other lymph node groups and in some cases, extra nodal abnormal accumulation of histiocytes may occur in other areas of the body that is more common in the head and neck region. Here we discussed a patient with extra-nodal involvement who presented with bilateral orbital mass.

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