scholarly journals Prevalence of toe symphalangism in Hong Kong Chinese population

2019 ◽  
Vol 26 (1) ◽  
pp. 56-60
Author(s):  
Yi-Lok Charis Chan ◽  
Wei-Hei Dao ◽  
Tsang Yeung ◽  
Esther Ching-San Chow

Objective: To explore the prevalence and variations of toe symphalangism in the Hong Kong Chinese population. Methods: A retrospective review of foot radiographs taken in Chinese adult patients admitted to United Christian Hospital from 1 January, 2016 to 31 December, 2016. Exclusion criteria include (1) previous toe amputation, (2) skeletal immaturity, (3) severe deformity, and (4) repeated attendance. The frequencies were compared by χ 2 test. Result: A total of 1364 foot radiographs were reviewed. Six-hundred sixty radiographs were excluded. A total of 704 radiographs were included in this study. There were total 849 feet reviewed (left: 290, right: 269, bilateral: 145). Their mean age (± standard deviation) was 59.5 ± 14.2 years. The prevalence of 2nd, 3rd, 4th, and 5th toe symphalangism was 0.2%, 0.8%, 9.9%, and 76.7%, respectively. The prevalence resembles Asian population. There was no significant difference in the prevalence associated with the following factors: (1) gender and (2) left versus right foot. There was no 4th toe symphalangism without 5th toe involvement. In the 145 bilateral feet radiographs, asymmetrical distribution of toe symphalangism was found in 8.2%. Second toe symphalangism is rare (0.24%). Conclusion: This is the first study in Hong Kong to report prevalence of toe symphalangism in Chinese population. There is a high prevalence rate of 5th toe symphalangism in the Hong Kong Chinese Population. This implies less flexible lesser toes in the Chinese population with higher risks of development of deformities. The clinical implication of such findings needs further research.

2000 ◽  
Vol 46 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Mercè Garcia-Barceló ◽  
Lok Yee Chow ◽  
Helen Fung Kum Chiu ◽  
Yun Kowk Wing ◽  
Dominic Tak Shing Lee ◽  
...  

Abstract Background: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydroxylase activity because of the presence of a C188→T mutation in exon 1. Methods: One hundred nineteen Hong Kong Chinese subjects were genotyped by means of allele-specific PCR, PCR, and restriction enzyme analysis for 10 CYP2D6 alleles (CYP2D6*1, *2, *4D, *5, *8/*14, *10A, *10B, *15, *16, and J9). Results: CYP2D6*10B was the most prevalent allele, and CYP2D6*10/CYP2D6*10 was the most frequent genotype, representing 46.22% of the population. Conclusions: There was no significant difference in the prevalence of the alleles analyzed between our study and the Chinese populations genotyped previously. This is the largest study in terms of the number of CYP2D6 alleles analyzed in an Oriental population and the first one conducted in a Hong Kong Chinese population.


2020 ◽  
Vol 98 (5) ◽  
Author(s):  
Jason C. Yam ◽  
Shu Min Tang ◽  
Ka Wai Kam ◽  
Li Jia Chen ◽  
Marco Yu ◽  
...  

2008 ◽  
Vol 22 (10) ◽  
pp. 714-716 ◽  
Author(s):  
M C S Wong ◽  
J Y Jiang ◽  
A T Lam ◽  
H Fung ◽  
S Griffiths ◽  
...  

Epilepsia ◽  
2008 ◽  
Vol 42 (1) ◽  
pp. 94-97 ◽  
Author(s):  
A. C. F. Hui ◽  
A. Tang ◽  
K. S. Wong ◽  
V. Mok ◽  
R. Kay

2008 ◽  
Vol 26 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Samuel Yeung Shan Wong ◽  
Frank Wan Kin Chan ◽  
Chi Kei Lee ◽  
Martin Li ◽  
Fai Yeung ◽  
...  

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