scholarly journals Expression and significance of SDF-1 and its receptor CXCR4 in the retina of pregnant rats after optic nerve injury

2018 ◽  
Vol 16 ◽  
pp. 205873921881967 ◽  
Author(s):  
Tiegang Liu ◽  
Xin Tang ◽  
Ling Yao ◽  
Hui Song
Keyword(s):  
Optic Nerve ◽  
Western Blot ◽  
Nerve Injury ◽  
Normal Group ◽  
Immunofluorescence Staining ◽  
Optic Nerve Injury ◽  
Western Blot Assay ◽  
Pregnant Rats ◽  
Stromal Cell Derived Factor ◽  
Experimental Group

Stromal cell–derived factor 1 (SDF-1) and its receptor CXCR4 have shown to play a role in embryonic development process, regulation of hematopoiesis, mediating immunology response, inflammatory reaction, and metastasis of malignant tumor. Recently, SDF-1 and CXCR4 are also closely related to retinal neovascularization. This study was to investigate the expression of SDF-1 and CXCR4 in the retina after optic nerve injury in pregnant rats so as to reveal its significance. A total of 12 pregnant rats were randomly divided into normal group and experimental group (after 5 days of optic nerve injury), six rats in each group; expressions of SDF-1 as well as CXCR4 in rat retina were detected by immunofluorescence staining and western blot assay. The result of immunofluorescence staining showed that the relative gray scale values of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group ( P < 0.05), and the result of Western blot assay showed that the expression levels of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group ( P < 0.05). In conclusion, SDF-1 and its receptor CXCR4 have abnormal expression in the retina of pregnant rats after optic nerve injury, which may be involved in the occurrence and development of optic nerve injury.

scholarly journals Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in the rat retina upon optic nerve injury

2015 ◽  
Vol 21 (1) ◽  
pp. 167-178 ◽  
Author(s):  
Thomas Schmidt ◽  
Dietmar Fischer ◽  
Anastasia Andreadaki ◽  
Britta Bartelt-Kirbach ◽  
Nikola Golenhofen
Keyword(s):  
Optic Nerve ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Nerve Injury ◽  
Small Heat Shock Proteins ◽  
Optic Nerve Injury ◽  
Rat Retina ◽  
Αb Crystallin ◽  
Shock Proteins

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss

Glia ◽  
2010 ◽  
pp. NA-NA ◽  
Author(s):  
Janice L. Son ◽  
Ileana Soto ◽  
Ericka Oglesby ◽  
Teresa Lopez-Roca ◽  
Mary E. Pease ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Optic Nerve Injury

Change of gene expression profiles in the retina following optic nerve injury

2002 ◽  
Vol 101 (1-2) ◽  
pp. 82-92 ◽  
Author(s):  
An-Guor Wang ◽  
Chu-Hsuan Chen ◽  
Chu-Wen Yang ◽  
May-Yung Yen ◽  
Wen-Ming Hsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Optic Nerve ◽  
Nerve Injury ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Optic Nerve Injury

scholarly journals AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury

2017 ◽  
Vol 58 (14) ◽  
pp. 6091 ◽  
Author(s):  
Robert W. Nickells ◽  
Heather M. Schmitt ◽  
Margaret E. Maes ◽  
Cassandra L. Schlamp
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Mouse Retina ◽  
Optic Nerve Injury

scholarly journals Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192348 ◽  
Author(s):  
Wissam Chiha ◽  
Chrisna J. LeVaillant ◽  
Carole A. Bartlett ◽  
Alex W. Hewitt ◽  
Phillip E. Melton ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Differentially Expressed ◽  
Optic Nerve Injury ◽  
Secondary Degeneration
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