scholarly journals CRK SH3N Domain Diminishes Cell Invasiveness of Non-Small Cell Lung Cancer

2013 ◽  
Vol 4 (7-8) ◽  
pp. 315-324 ◽  
Author(s):  
G. H. Pezeshkpour ◽  
F. Moatamed ◽  
M. Lewis ◽  
B. Hoang ◽  
M. Rettig ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness

Abstract 3070: Suppression of tumor cell invasiveness andin vivotumor growth by microRNA-874 in non-small cell lung cancer.

2013 ◽  
Author(s):  
Divya Kesanakurti ◽  
Dilip Maddirela ◽  
Subramanyam Chittivelu ◽  
Jasti S. Rao ◽  
Chandramu Chetty
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness

scholarly journals Placental Growth Factor Promotes Metastases of Non-Small Cell Lung Cancer Through MMP9

2015 ◽  
Vol 37 (3) ◽  
pp. 1210-1218 ◽  
Author(s):  
Wei Zhang ◽  
Ting Zhang ◽  
Yuqing Lou ◽  
Bo Yan ◽  
Shaohua Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Molecular Mechanisms ◽  
Small Cell ◽  
Placental Growth Factor ◽  
Small Cell Lung ◽  
Cell Invasiveness

Background/Aims: Neovascularization and invasion coordinate cancer metastases in non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms are poorly understood. Recently, a substantial role of placental growth factor (PLGF) in cancer cell invasion has been acknowledged in several types of cancer, whereas a possible involvement of PLGF in the metastases of NSCLC has not been studied. Methods: Here, we analyzed the levels of PLGF and matrix metalloproteinase 9 (MMP9) in NSCLC specimens. We modified either PLGF or MMP9 levels in a NSCLC cell line A549, and examined the effects on the levels of MMP9 and PLGF. The cell invasiveness was quantified in a transwell cell migration assay. Pathway inhibitors were applied to determine the molecular mechanisms underlying the control of MMP9 by PLGF. Results: We found that PLGF and MMP9 levels both significantly increased in the NSCLC specimens and were strongly correlated. Overexpression of PLGF in NSCLC cells increased the levels of MMP9 and cell invasiveness, while inhibition of PLGF in NSCLC cells decreased the levels of MMP9 and cell invasiveness. However, modification of MMP9 levels in NSCLC cells did not alter the levels of PLGF. These data suggest that PLGF may regulate MMP9 in NSCLC cells, but not vice versa. Moreover, inhibition of MMP9 in PLGF-overexpressing NSCLC cells abolished the effects of PLGF on cell invasiveness, suggesting that PLGF increases cell invasion via MMP9. Furthermore, suppression of MAPK-p38, but not suppression of either MAPK-p42/p44, or PI3k, or JNK signaling, substantially abolished the effect of PLGF on MMP9, suggesting that PLGF may activate MMP9 via MAPK-p38 signaling pathway. Conclusion: PLGF-stimulated cancer invasion may be mediated through its effects on MMP9 activation in NSCLC cells.

scholarly journals Human Kallikrein 8 Protease Confers a Favorable Clinical Outcome in Non–Small Cell Lung Cancer by Suppressing Tumor Cell Invasiveness

2006 ◽  
Vol 66 (24) ◽  
pp. 11763-11770 ◽  
Author(s):  
Yuh-Pyng Sher ◽  
Cheng-Chung Chou ◽  
Ruey-Hwang Chou ◽  
Han-Ming Wu ◽  
Wun-Shaing Wayne Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Outcome ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Favorable Clinical Outcome ◽  
Cell Invasiveness

scholarly journals Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer

2013 ◽  
Vol 434 (3) ◽  
pp. 627-633 ◽  
Author(s):  
Divya Kesanakurti ◽  
Dilip Rajasekhar Maddirela ◽  
Subramanyam Chittivelu ◽  
Jasti S. Rao ◽  
Chandramu Chetty
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness
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