Advances in Insulin Pump Infusion Sets Symposium Report

2021 ◽  
pp. 193229682199908
Author(s):  
Jennifer Y. Zhang ◽  
Trisha Shang ◽  
Sarnath Chattaraj ◽  
Ohad Cohen ◽  
Matthias Heschel ◽  
...  

Continuous subcutaneous insulin infusion (CSII) is becoming increasingly used for achieving target glycemic control as well as providing flexibility in lifestyle. In a widely used version of CSII, the insulin pump itself is attached to one end of an insulin infusion set (IIS), which delivers insulin via a thin flexible plastic tube to the patient’s body via a cannula or needle that is inserted under the skin at the other end of the IIS. Despite the increased use of CSII by patients with diabetes, there have been few recent advances in IIS technology, especially when compared to the many recent advances made in insulin pump technology and in insulin pharmacokinetics. To discuss recent developments in, and future plans for IIS development, Diabetes Technology Society virtually hosted the Advances in Insulin Pump Infusion Sets Symposium on December 1, 2020. This symposium featured experts in the field of IISs, including representatives from Medtronic and ConvaTec (which are two manufacturers that are currently developing IISs), Stanford University, Steno Diabetes Center Copenhagen, and Science Consulting in Diabetes. The webinar’s six speakers covered (1) patient burden, (2) extended wear technology, and (3) future directions in IIS development.

Diabetes tsunami has hit India in a very devastating way in last decade. There is no doubt that CSII with Insulin pump Therapy has proved superior to MDI (multiple Dose Injection) therapy in Type1DM as well as Type2DM patients. Economics has been a very important issue while advocating the Pump to either patients, type 1 or type 2 Diabetes Mellitus patients. Out of 9 (Nine) patients using Insulin Pumps in our centre GANDHI CLINIC, PUNE, INDIA there are 5 Type 2 patients and 4 Type 1DM patients. Two Pumps are deposited at my Clinic due to the sad demise of the Type2DM patients. The relatives of these patients do wish to sell these pumps with some depreciation price i.e. at lower price than the new one. One patient (type2DM) has stopped using the Insulin pump due to the adverse advice from another healthcare provider who also wants to sell the pump at some discounted price. As per my survey in the Metro city of Pune (INDIA) approximately 700 insulin pumps are sold, out of these at least 5-7% of total pumps are not being used anymore. The unused pumps are at least 50 in number. Therefore revenue in terms of PUMPS in one region of INDIA is about 70000 US Dollars. Total number of pumps used in INDIA is 70000-72000 pumps approx. The total unused pumps by the patients could be about 3000 to 5000 pumps in total and thereby the revenue loss in this resource constrained country could be in millions of Dollars. This scenario is probably the same scene in many developing countries wherein the healthcare budgets are limited. In INDIA, Insulin Pump Therapy is not yet covered by Insurance policy of the patients. Since the pumps are usually purchased thru pocket expenses or with Loan or selling some assets like land or Gold, the relatives of the patients are not wrong in expecting some financial recovery after losing the most important thing i.e. the PERSON or even if patient does not want to continue the use of pump due to any reason. We do see refurbished cars sold and there are eligible and deserving candidates available who cannot purchase a new model of the Car. I am sure INDIA is an important market of Diabetes Technology related Products like Insulin Pump, similar to the many developing countries. This article is aimed at KOLs in Dialectology and Economists in the world for a basic policy change in favour of the patient care.


2016 ◽  
Vol 18 (11) ◽  
pp. 713-718 ◽  
Author(s):  
Alex Ramirez-Rincon ◽  
Jaime Hincapie-García ◽  
Claudia Monsalve Arango ◽  
Natalia Aristizabal ◽  
Estefany Castillo ◽  
...  

The essays collected in this book represent recent advances in our understanding of speech acts-actions like asserting, asking, and commanding that speakers perform when producing an utterance. The study of speech acts spans disciplines, and embraces both the theoretical and scientific concerns proper to linguistics and philosophy as well as the normative questions that speech acts raise for our politics, our societies, and our ethical lives generally. It is the goal of this book to reflect the diversity of current thinking on speech acts as well as to bring these conversations together, so that they may better inform one another. Topics explored in this book include the relationship between sentence grammar and speech act potential; the fate of traditional frameworks in speech act theory, such as the content-force distinction and the taxonomy of speech acts; and the ways in which speech act theory can illuminate the dynamics of hostile and harmful speech. The book takes stock of well over a half century of thinking about speech acts, bringing this classicwork in linewith recent developments in semantics and pragmatics, and pointing the way forward to further debate and research.


Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5270
Author(s):  
Zhenbo Yuan ◽  
Xuanzhong Liu ◽  
Changmei Liu ◽  
Yan Zhang ◽  
Yijian Rao

Non-proteinogenic amino acids have attracted tremendous interest for their essential applications in the realm of biology and chemistry. Recently, rising C–H functionalization has been considered an alternative powerful method for the direct synthesis of non-proteinogenic amino acids. Meanwhile, photochemistry has become popular for its predominant advantages of mild conditions and conservation of energy. Therefore, C–H functionalization and photochemistry have been merged to synthesize diverse non-proteinogenic amino acids in a mild and environmentally friendly way. In this review, the recent developments in the photo-mediated C–H functionalization of proteinogenic amino acids derivatives for the rapid synthesis of versatile non-proteinogenic amino acids are presented. Moreover, postulated mechanisms are also described wherever needed.


RSC Advances ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5411-5425
Author(s):  
Somayeh Tajik ◽  
Zahra Dourandish ◽  
Peyman Mohammadzadeh Jahani ◽  
Iran Sheikhshoaie ◽  
Hadi Beitollahi ◽  
...  

This review article aims to provide an overview of the recent advances in the voltammetric and amperometric sensing of cysteine (Cys).


1995 ◽  
Vol 48 (4) ◽  
pp. 189-212 ◽  
Author(s):  
G. J. Brereton ◽  
R. R. Mankbadi

Turbulent flow which undergoes organized temporal unsteadiness is a subject of great importance to unsteady aerodynamic and thermodynamic devices. Of the many classes of unsteady flows, those bounded by rigid smooth walls are particularly amenable to fundamental studies of unsteady turbulence and its modeling. These flows are presently being given increased attention as interest grows in the prospect of predicting non-equilibrium turbulence and because of their relevance to turbulence–acoustics interactions, in addition to their importance as unsteady flows in their own right. It is therefore timely to present a review of recent advances in this area, with particular emphasis placed on physical understanding of the turbulent processes in these flows and the development of turbulence models to predict them. A number of earlier reviews have been published on unsteady turbulent flows, which have tended to focus on specific aspects of certain flows. This review is intended to draw together, from the diverse literature on the subject, information on fundamental aspects of these flows which are relevant to improved understanding and development of predictive models. Of particular relevance are issues of instability and transition to turbulence in reciprocating flows, the robustness of coherent structures in wall-bounded flows to forced perturbations (in contrast to the relative ease of manipulation in free shear flows), unsteady scalar transport, improved measurement technology, recent contributions to target data for model testing and the quasi-steady and non-steady rapid distortion approaches to turbulence modeling in these flows. The present article aims to summarize recent contributions to this research area, with a view to consolidating comprehension of the well-known basics of these flows, and drawing attention to critical gaps in information which restrict our understanding of unsteady turbulent flows.


2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.


2017 ◽  
Vol 1 (11) ◽  
pp. 2155-2173 ◽  
Author(s):  
Kaihua Liu ◽  
Haixia Zhong ◽  
Fanlu Meng ◽  
Xinbo Zhang ◽  
Junmin Yan ◽  
...  

The recent developments of metal–nitrogen–carbon catalysts for electrochemical water splitting have been comprehensively summarized.


Author(s):  
H Singh ◽  
Amy Bamrah ◽  
Sanjeev Kumar ◽  
A Deep ◽  
M Khatri ◽  
...  

Recent developments in nanotechnology and engineering have produced a plethora of nanomaterials with amazing physical/chemical properties and enhanced sensing potential for various heavy metals in the environment. Noble metal nanoparticles...


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