A randomised controlled trial comparing the effects of micronized progesterone to medroxyprogesterone acetate on cardiovascular health, lipid metabolism and the coagulation cascade in women with premature ovarian insufficiency: Study protocol and review of the literature

2013 ◽  
Vol 19 (3) ◽  
pp. 127-132 ◽  
Author(s):  
M. Mittal ◽  
M. Savvas ◽  
R. Arya ◽  
C. McEniery ◽  
N. Narvekar ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Randomised Controlled Trial ◽  
Medroxyprogesterone Acetate ◽  
Cardiovascular Health ◽  
Controlled Trial ◽  
Coagulation Cascade ◽  
Review Of The Literature ◽  
Ovarian Insufficiency ◽  
Randomised Controlled ◽  
Micronized Progesterone

scholarly journals Text messages for primary prevention of cardiovascular disease: the TextMe2 randomised controlled trial protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e036767
Author(s):  
Harry Klimis ◽  
Aravinda Thiagalingam ◽  
Clara K Chow
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Medication Adherence ◽  
Primary Prevention ◽  
Randomised Controlled Trial ◽  
Cardiovascular Health ◽  
Controlled Trial ◽  
Text Messages ◽  
Randomised Controlled

IntroductionMobile health may be an effective means of delivering customised individually directed health promotion interventions for cardiovascular disease (CVD) primary prevention. The aim of this study is to evaluate the effectiveness of a lifestyle-focused text messaging programme for primary CVD prevention.Methods and analysisSingle-blind randomised controlled trial with 6 months’ follow-up in 246 patients with moderate-high absolute cardiovascular risk and without coronary heart disease recruited from a rapid access cardiology clinic. Participants will be randomised to receive either usual care or TextMe2 (text message-based prevention programme). The TextMe2 programme provides support, motivation and education on five topics: diet, physical activity, smoking, general cardiovascular health and medication adherence, and is delivered in four text messages per week over 6 months. The primary outcome is change in the proportion of patients who have three or more of five key modifiable risk factors that are uncontrolled (low-density lipoprotein >2.0 mmol/L, systolic blood pressure >140 mm Hg, body mass index >24.9 kg/m2, physical activity (less than the equivalent of 150 min of moderate intensity each week), current smoker). Secondary outcomes are changes in single biomedical risk factors, behavioural risk factors, quality of life, depression/anxiety scores, medication adherence, cardiovascular health literacy and hospital readmissions/representations. Analysis will be according to the intention-to-treat principle and full statistical analysis plan developed prior to data lock.Ethics and disseminationThis study has been approved by the Western Sydney Local Health District Human Research Ethics Committee at Westmead (AU/RED/HREC/17/WMEAD/186). Results will be presented at scientific meetings and published in peer-reviewed publications.Trial registration numberACTRN12618001153202.

Sign in / Sign up

Export Citation Format

Share Document